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| 1 | Complex role for the immune system in initiation and progression of pancreatic cancer显示文摘The immune system plays a complex role in the development and progression of pancreatic cancer. Inflammation can promote the formation of premalignant lesions and accelerate pancreatic cancer development. Conversely, pancreatic cancer is characterized by an immunosuppressive environment, which is thought to promote tumor progression and invasion. Here we review the current literature describing the role of the immune response in the progressive development of pancreatic cancer, with a focus on the mechanisms that drive recruitment and activation of immune cells at the tumor site, and our current understanding of the function of the immune cell types at the tumor. Recent clinical and preclinical data are reviewed, detailing the involvement of the immune response in pancreatitis and pancreatic cancer, including the role of specific cytokines and implications for disease outcome. Acute pancreatitis is characterized by a predominantly innate immune response, while chronic pancreatitis elicits an immune response that involves both innate and adaptive immune cells, and often results in profound sys-temic immune-suppression. Pancreatic adenocarcinoma is characterized by marked immune dysfunction driven by immunosuppressive cell types, tumor-promoting immune cells, and defective or absent inflammatory cells. Recent studies reveal that immune cells interact with cancer stem cells and tumor stromal cells, and these interactions have an impact on development and progression of pancreatic ductal adenocarcinoma(PDAC). Finally, current PDAC therapies are reviewed and the potential for harnessing the actions of the immune response to assist in targeting pancreatic cancer using immunotherapy is discussed. | Kristin S Inman Amanda A Francis Nicole R Murray | 2014 | World Journal of Gastroenterology2014，20，32： | 11 |
| 2 | Auditor brand name reputations and industry specializations显示文摘 | Allen T Craswell Jere R Francis Stephen L Taylor | 1995 | Journal of Accounting and Economics1995，，3： | 4 |
| 3 | Does size matter? The influence of large clients on office-level auditor reporting decisions显示文摘 | J.Kenneth Reynolds Jere R Francis | 2001 | Journal of Accounting and Economics2001，，3： | 2 |
| 4 | Costs of Equity and Earnings Attributes显示文摘 | Lafond R Olsson P M Schipper K | 2004 | The Accounting Review2004，79，4： | 1 |
| 5 | Plant responses of ultra narrow row cotton to nitrogen fertilization显示文摘 | MCCONNEL J S Francis P B Stark C R | 2008 | Journal of Plant Nutrition2008，31，： | 1 |
| 6 | Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘 | Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger | 2000 | lnternation Journal of Applied Earth Ob- servation and Geoinformation2000，2，2： | 1 |
| 7 | Conversion of a RAPD-generated PCR product, containing a novel dispersed repetitive element,into a last and robust assay for the pres- ence of rye chromatin in wheat 显示文摘 | Francis H A Leitch A R Koebner R M D | 1995 | Theoretical and Applied Genetics1995，90，： | 1 |
| 8 | Evidence for Abstract, Schematic Knowledge of Three Spatial Diagram Representations 显示文摘 | Novick L R Hurley S M Francis M | 1999 | Memory Cognition1999，27，2： | 1 |
| 9 | Effects of Strength Training onMuscle Development in Prepubescent, Pubescent, andPostpubescent Males显示文摘 | Pfeiffer R D Francis R S | 1986 | Physician and Sportsmedicine1986，14，9： | 1 |
| 10 | Al/stainless - invar com- posites with tailored anisotropy for thermal management in light weight electronic packaging 显示文摘 | Sophie R Anne M Francis D | 2015 | Materials and De- sign2015，85，： | 1 |
| 11 | Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography 显示文摘 | Wang R K An L Francis P | 2010 | Optics Letters2010，35，9： | 1 |
| 12 | Comparing the accuracy and explainability of dividend, free cash flow, and abnormal earnings equity value estimates 显示文摘 | Francis J Olsson P Oswald D R | 2000 | Journal of Accounting Research2000，，38： | 1 |
| 13 | CdTe and CdZnTe detectors behavior in X-ray computed tomography conditions 显示文摘 | Stephane R Francis G Michel G | 2000 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2000，442，13： | 1 |
| 14 | Does size matter?the influence of large clients on office-level auditor reporting decisions显示文摘 | Reynolds J Francis R | 2001 | Journal of Accounting and Economic2001，30，： | 1 |
| 15 | The haemody-namic and catecholamine response to xenon/remifentanil an-aesthesia in Beagle dogs显示文摘 | Francis R C Reyle-Hahn M S Hohne C | 2008 | Lab Anim2008，42，3： | 1 |
| 16 | β-Cyclodextrin Post-Column Fluorescence Enhancement of Aflatoxins for Reverse-Phase Liguid Chromatographic Determination in Corn显示文摘 | Octavl J Francis J R Gary P | 1988 | J AOAC Int1988，71，4： | 1 |
| 17 | Comparison of medicaltherapy, pacing and defib rillation in heart failure ( COMPANION )trailterm inated early : combined biventricu - lar pacemaker defibril-lators reduce all - cause mortality and hospital ization显示文摘 | Salukhe TV Francis DP Sutton R | 2003 | Int J Car-diol2003，87，1： | 1 |
| 18 | Transmission ecology of Echinococcus multilocularis: What are the ranges of parasite stability among various host communities in China显示文摘 | Patrick G David P Francis R et ol | 2006 | Parasitol Inter2006，，： | 1 |
| 19 | Diffusion controlled growth of metallic nanoclusters at selected surface sites显示文摘 | Francis G M Kuipers L Palmer R E | 1996 | J Appl Phys1996，79，6： | 1 |
| 20 | Imide-modified polyure- thanes, syntheses, thermal, and mechanical Characteristics 显示文摘 | Nair P R K Nair C P R Francis D J | 1998 | J Appl Polym Sci1998，70，8： | 1 |
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