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| 1 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 2 | Bronchogenic cysts in the skin and subcutaneous tissue显示文摘 | Fraga S Helwig EB Rosen SH | 1971 | Am J Clin Pathol1971，56，2： | 1 |
| 3 | The aroma of Brazilian ambarella fruit (Spondias cythereu Sonnerat) 显示文摘 | Fraga S R G Rezende C M | 2001 | Journal of Essential Oil Research2001，13，： | 1 |
| 4 | Biotransformation of the diterpenes epicandicandiol and candicandiol by Mucor plumbeus 显示文摘 | Fraga B M Alvarez L Su6rez S | 2003 | J Nat Prod2003，66，3： | 1 |
| 5 | Procyani- dins can interact with Caco-2 cell membrane lipid rafts: in- volvement of cholesterol显示文摘 | Verstraeten S V Jaggers G K Fraga C G | 2013 | Biochim Biophys Acta2013，1828，11： | 1 |
| 6 | Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling,but does not involve NF kappa B显示文摘 | Das S Fraga CG Das DK | 2006 | Free Radic Res2006，40，10： | 1 |
| 7 | Comparison of sexualand drug use behaviors between female sex workers in Tijuanaand Ciudad Juarez, Mexico显示文摘 | Patterson T 1 Semple S J Fraga M | 2006 | Substance Use & Misuse y2006，41，1012： | 1 |
| 8 | DNA methyhransferases control telomere length and telomere recombination in mammalian cells 显示文摘 | Gonzalo S Jaco I Fraga M F | 2006 | Nat Cell Biol2006，8，4： | 1 |
| 9 | High HIF-1α expression genotypes in oral lichen planus显示文摘 | Carlos Alberto Carvalho Fraga Lucas Rodrigues Alves Luciano Marques-Silva Adriana Alkmim Sousa Antonio Sérgio Barcala Jorge Sabrina Ferreira Jesus Daniel Nogueira Vilela Ugo Borges Pinheiro Kimberly Marie Jones Alfredo Maurício Batista Paula André Luiz Se | 2013 | Clinical Oral Investigations2013，，9： | 1 |
| 10 | A New Technique to estimate initial spill size using a modified Fay-Type spreading formula显示文摘 | Lehr W J Fraga R J Belen M S | 1984 | Marine Pollution Bulletin1984，15，9： | 1 |
| 11 | A systematic profile of DNA methylation in human cancer cell lines显示文摘 | Paz MF Fraga MF Avila S | 2003 | Cancer Res2003，63，5： | 1 |
| 12 | DNA Methyltransferases Control Telomere Length and Telomere Recombination in Mammalian Cells显示文摘 | GONZALO S JACO I FRAGA M F | 2006 | Nature Cell Biol2006，8，： | 1 |
| 13 | Germ-line variants in methyl-guoup metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors显示文摘 | Paz MF Avila S Fraga MF | 2002 | Cancer Res2002，62，： | 1 |
| 14 | Computed tomography evaluation of temporomandibular joint alterations in patients with Class lI division 1 subdivision malocclusions: condyle-fossa relationship 显示文摘 | Vitral RW Telles Cde S Fraga MR | 2004 | Am J Orthod Dentofacial Orthop2004，126，1： | 1 |
| 15 | Gambierdiscus excentricus sp. nov. (Dinophyceae), a benthic toxic dinoflagellate from the Canary Islands (NE Atlantic Ocean)显示文摘 | Santiago Fraga Francisco Rodríguez Amandine Caillaud Jorge Diogène Nicolás Raho Manuel Zapata | 2011 | Harmful Algae2011，，： | 1 |
| 16 | A truncating muta- tion of HDAC2 in human cancers confers resistance to his- tone deacetylase inhibition 显示文摘 | Ropero S Fraga MF Ballestar E | 2006 | Nat Genet2006，38，5： | 1 |
| 17 | Parenting roles and know- ledge in neonatal intensive care units:protocol of a mixed methods study显示文摘 | Alves E Amorim M Fraga S | 2014 | BMJ Open2014，4，00： | 1 |
| 18 | Studies on SiC, DLC and TiO2 thin films as piezoresistive sensor materials for high temperature application 显示文摘 | FRAGA M A FURLAN H PESSOA R S | 2012 | Microsystem Technologies2012，18，78： | 1 |
| 19 | The intracellular distribution of small heat shock proteins in post-mortem beef is determined by ultimate pH显示文摘 | PULFORD D J FRAGA V S FROST D F | 2008 | Meat Science2008，79，4： | 1 |
| 20 | DNA methyltransferases control telomere length and telomere recombination in mammalian cells显示文摘 | Gonzalo S Jaco I Fraga MF | 2006 | Nat Cell Biol2006，8，4： | 1 |
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