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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Influence of chemical and biological factors on tropic transfer of persistent organic pollutants in the North water polynya marine food web显示文摘 | FISK A T HOBSON K A NORSTROM R J | 2001 | Environ Sci Technol2001，35，： | 1 |
| 3 | Sensor-based demand-cont -rolled ventilation: a review 显示文摘 | William J Fisk Anibal T De Almeida | 1998 | Energy and Buildings1998，29，： | 1 |
| 4 | The frontiers in service con- ference:a 20-year retrospective 显示文摘 | Dorsch M J Fisk R P Grove S J | 2014 | The Service Industries Jour- nal2014，34，6： | 1 |
| 5 | Tracking the evolution of the service marketing literature显示文摘 | Fisk B Bitner M J | 1993 | Journal of Retailing1993，69，1： | 1 |
| 6 | Tamsulosin reduces the incidence of acute u- rinary retention following early removal of the urinary catheter after radi- cal retropubic prostatectomy 显示文摘 | Patel R Fiske J Lepor H | 2003 | Urology2003，62，2： | 1 |
| 7 | The effect of GABAA antagonist bicuculline on dorsal raphe nucleus and frontal cortex extracellular serotonin: a window on SWS and REM sleep modulation 显示文摘 | FISKE E GRONLI J BJORVATN B | 2006 | Pharmacol Biochem Behav2006，83，2： | 1 |
| 8 | Application of genomics and proteomics for identification of bacterial gene products as potential vaccine candidates显示文摘 | Deb N Chakravarti Michael J Fiske Leah D Fletcher Robert J Zagursky | 2001 | Vaccine2001，，6： | 1 |
| 9 | Acute enantiose- lective toxicity of fipronil and its desulfinyl photoproduct to Ceriodaphnia dubia显示文摘 | Konwick B J Fisk A T Garrison A W | 2005 | Environ Toxicol Chem2005，24，9： | 1 |
| 10 | Effect of matrix metalloproteinases activity on outflow in perfused human organ culture显示文摘 | Bradley JM Vranka J Colvis CM Conger DM Alexander JP Fisk AS | 1998 | Invest Ophthalmol Vis Sci1998，39，： | 1 |
| 11 | Tracking the Evolution of the Services Marketing Literature显示文摘 | Brown S W Bitner M J | 1993 | Journal of Retailing1993，69，1： | 1 |
| 12 | Respecting Versus Liking:Status and Interdependence Predict Ambivalent Stereotypes of Competence and Warmth显示文摘 | Fiske S T J Xu | 1999 | Journal of social issues1999，55，3： | 1 |
| 13 | Guideline for oral health care for long-stay patients and residents 显示文摘 | Fiske J Griffiths J Jamieson R | 2000 | Gerodontology2000，17，1： | 1 |
| 14 | Influence of chemical and biological factors on trophic transfer of persistent organic pollutants in the northwater polynya marine food web 显示文摘 | FISK A T HOBSON K A NORSTROM R J | 2001 | Environmental Science and Technology2001，35，： | 1 |
| 15 | The impact of other customers on service experiences: a critical incident examination of: 'getting along' 显示文摘 | Grove S J and Fisk R P | 1997 | Journal of Retailing1997，，1： | 1 |
| 16 | Is CO2 an Indoor Pollutant? Direct Effects of Low-to-Moderate CO2 Concentrations on Human Decision-Making Performance显示文摘 | Satish Usha Mendell Mark J Shekhar Krishnamurthy Hotchi Toshifumi Sullivan Douglas Streufert Siegfried Fisk William J | 2012 | Environmental Health Perspectives2012，，12： | 1 |
| 17 | Therapeutic potential of p38 MAP kinase inhibition in the management of cardi- ovascular disease 显示文摘 | Fisk M Gajendragadkar PR M~ki-Pet~j~ KM | 2014 | Am J Cardiovasc Drugs2014，14，3： | 1 |
| 18 | Hexachlorocyclohexane (HCH) isomers and chiral signatures of r-HCH in the arctic marine food web of the northwater polynya 显示文摘 | MOISEY J FISK A HOBSON K | 2001 | Environmental Science &Technology2001，35，： | 1 |
| 19 | Microbial Activity and Functional Composition among Northern Peatland Ecosystems显示文摘 | FISK M C RUETHER K F YAVITT J B | 2003 | Soil Biology & Biochemistry2003，35，4： | 1 |
| 20 | The colorimetric determination of phos- phorus显示文摘 | Fiske C H Subbarow Y J | 1925 | Biol Chem1925，66，： | 1 |
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