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| 1 | BMC Family Practice论文摘要汇编——基层医疗机构慢性病患者自我管理支持研究:患者自我管理问题的频率、自我管理事项优先级排序及其与医疗团队成员为其设定的行为目标的一致性显示文摘背景为了提供高质量的以患者为中心的诊疗服务,在初级保健卫生系统中融入适当的资源以支持患者发现自我管理中存在的问题以及自我管理事项的优先安排是否合理,有必要研制出实用的系统的评估患者自我管理需求及管理事项优先安排是否合理的方法。本研究对Connection to Health(CTH)数据库里的资料进行分析,分析患者报告自我管理中问题出现的频率以及管理事项安排的优先排序,并探究患者自我管理事项的优先排序与患者诊疗小组成员为其设定的最终行为目标是否一致。 | HESSLER D M FISHER L BOWYER V 本刊编辑部 | 2019 | 中国全科医学2019，22，32： | 4 |
| 2 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 3 | Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design显示文摘Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke onset.Methods and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority study.Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 mg.Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 days.Secondary efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale.Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.Discussion There is no completed registration study of TNK in AIS worldwide.TRACE Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China. | Shuya Li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 2 |
| 4 | Manipulating meat quality and composition 显示文摘 | WOOD J D ENSER M FISHER A V | 1999 | Proc Nutr Soc1999，58，2： | 1 |
| 5 | Monitoring of atmospheric deposition in European forests and an overview on its implication on forest condition显示文摘 | Fisher R Mues V Ulrich E | 2007 | Applied Geochemistry2007，22，6： | 1 |
| 6 | Good laboratory practice:Preventing introduction of bias at the bench显示文摘 | Macleod MR Fisher M O'Collins V | 2009 | Stroke2009，40，： | 1 |
| 7 | Swirling flow pattern in a non-planar model of an interposition vein cuff anastomosis 显示文摘 | T V How R K Fisher J A Brennan | 2006 | Med Eng Phys2006，，28： | 1 |
| 8 | Risk attitude reversals in drivers' route choice when range of travel time is provided 显示文摘 | Katsikopoulos K V Fisher D L Duse Anthony | 2002 | Human Factors2002，44，3： | 1 |
| 9 | Lipoprotein lipase variants D9N and N291S are associated with increased plasma triglyceride and lower high-density lipoprotein cholesterol concentrations: studies in the fasting and postprandial states: the European Atherosclerosis Research Studies 显示文摘 | Gerdes C Fisher RM Nicaud V Boer J Humphries SE Talmud PJ | 1997 | Circulation1997，96，3： | 1 |
| 10 | An in-situ HVEM study of dislocation generation at Al/SiC interfaces in metal matrix composites显示文摘 | Mary V Arsenault R J Fisher R M | | 0，，： | 1 |
| 11 | Delayed neuropathology after carbon monoxide poisoning is immune-mediated显示文摘 | THOM S R BHOPALE V M FISHER D | 2004 | Proc Natl Acad Sci USA2004，101，13： | 1 |
| 12 | Investigations of the reactions of monochloramine and dichloramine with selected phenols: Examination of humic acid models and water contaminants显示文摘 | Heasley V L Fisher A M Herman E E | 2004 | Environ Sci Technol2004，38，19： | 1 |
| 13 | The role of environmen-tal factors in the etiology of lymphoma显示文摘 | BLINDER V FISHER S G | 2008 | Cancer In-vest2008，26，： | 1 |
| 14 | Receptor regulation of the volume-sensitive efflux of taurine and iodide from human SH-SY5Y neuroblastoma cells:differential requirements for Ca2+ and protein kinase C显示文摘 | CHEEMA T A PETTIGREW V A FISHER S K | 2007 | The Journal of Pharmacology and Experimental Therapeutics2007，320，3： | 1 |
| 15 | Effect of matrix ductility on deformation behavior of steel reinforced ECC flexural members under reversed cyclic loading condition显示文摘 | Fisher G Li V C | 2002 | ACI Structural Journal2002，99，6： | 1 |
| 16 | Sedimentary structures in base-surge deposits with special reference to cross-bedding, Ubehebe Craters, Death Valley, California显示文摘 | CROWE B M FISHER R V | 1973 | Geological Society of America Bulletin1973，84，： | 1 |
| 17 | Intrinsic response control of moment resisting frames utilizing advanced composite materials and structural elements显示文摘 | Fisher G Li V C | 2003 | ACI Structural Journal2003，100，2： | 1 |
| 18 | An assessment of the )oint associations of aspirin and statin usewitb Creactive protein con- centration 显示文摘 | Fisher M Cushman M Knappertz V | 2008 | Am Heart J2008，156，： | 1 |
| 19 | Lithium battery mate- rials LiMPO4 (M : Mn, Fe, Co, and Ni):insights into defect as- sociation, transport mechanisms, and doping behavior 显示文摘 | Fisher C A Hart Prieto V M Islam M S | 2008 | Chemistry of Materials2008，20，59： | 1 |
| 20 | Enterovirus 2Apro targets MDA5and MAVS in infected cells显示文摘 | Feng Q Langereis M A Lork M Nguyen M Hato S V Lanke K Emdad L Bhoopathi P Fisher P B Lloyd R E van Kuppeveld F J | 2014 | J Virol2014，88，6： | 1 |
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