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| 1 | Caenorhabditis elegans mom-4 is required for the activation of the p38 MAPK signaling pathway in the response to Pseudomonas aeruginosa infection显示文摘The p38 mitogen-activated protein kinase(MAPK)plays an evolutionarily conserved role in the cellular re-sponse to microbial infection and environmental stress.Activation of p38 is mediated through phosphorylation by upstream MAPKK,which in turn is activated by MAPKKK.In the Caenorhabditis elegans,the p38 MAPK(also called PMK-1)signaling pathway has been shown to be required in its resistance to bacterial infection.However,how different upstream MAP2Ks and MAP3Ks specifically contribute to the activation of PMK-1 in response to bacterial infection still is not clearly un-derstood.By using double-stranded RNA-mediated interference(RNAi)and genetic mutants of C.elegans,we demonstrate that C.elegans MOM-4,a mammalian TAK1 homolog,is required for the resistance of C.elegans to a P.aeruginosa infection.We have also found that the MKK-4 of C.elegans is required for P.aeruginosa resistance,but not through the regulation of DLK-1.In summary,our results indicate that different upstream MAPKKKs or MAPKKs regulate the activation of PMK-1 in response to P.aeruginosa. | Ajing Xu Guojun Shi Feng Liu Baoxue Ge | 2013 | Protein & Cell2013，4，1： | 3 |
| 2 | Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor,histamine,and serotonin显示文摘 | Feng D Nagy AJ Hipp J | 1996 | J Exp Med1996，183，： | 1 |
| 3 | Hypoxic preconditioning provides neuroprotection and increases vascular endothelial growth factor A, preserves the phosphorylation of Akt-Ser473 and diminishes the in- crease in caspase-3 activity in neonatal rat hypoxic-ischemic model 显示文摘 | Feng YZ Rhodes PG Bhatt AJ | 2010 | Brain Res2010，1325，： | 1 |
| 4 | The coordinate regulation of the p53 and m TOR pathways in cells显示文摘 | Feng Z Zhang H Levine AJ | 2005 | Proc Natl Acad Sci U S A2005，102，23： | 1 |
| 5 | Neuroprotective effects of vascular endo- thelial growth factor following hypoxic ischemic brain injury in neonatal rats显示文摘 | Feng Y Rhodes PG Bhatt AJ | 2008 | Pediatr Res2008，64，4： | 1 |
| 6 | Neuroprotective effects of vascular endothelial growth factor following hypoxic ischemic brain injury in neonatal rats显示文摘 | Feng Y Rhodes PG Bhatt AJ | 2008 | Pediatr Res2008，64，4： | 1 |
| 7 | Dexamethasone induces apoptosis of progenitor cells in the subventricular zone and dentate gyrus of developing rat brain显示文摘 | Bhatt AJ Feng Y Wang J | 2013 | J Neurosci Res2013，91，9： | 1 |
| 8 | Cellular interactions of virion infectivity factor (Vif) as potential therapeutic targets: APOBEC3G and more- 显示文摘 | Carr JM Davis AJ Feng F | 2006 | Curr Drug Targets2006，7，： | 1 |
| 9 | Coordination and communication between the p53 and IGF - 1 AKT - TOR signal transduction pathways显示文摘 | LEVINE AJ FENG ZHH MAK TW | 2006 | Genes & Develop ment2006，20，3： | 1 |
| 10 | Inflammation status of rab-bit carotid artery moriel endothelium during intermittent hypoxiaexposure and its relationship with leptin显示文摘 | FENG J CHEN BY CUI LY et aJ | 2009 | Sleep Breath2009，13，3： | 1 |
| 11 | The coordinate regulation of the p53 and roTOR pathways in cells显示文摘 | Feng Z Zhang H Levine AJ | 2005 | PNAS2005，102，23： | 1 |
| 12 | The P53 pathway : what questions re-main to be explored 显示文摘 | Levine AJ Hu W Feng Z | 2006 | Cell Death Differ2006，13，6： | 1 |
| 13 | Hypoxic preconditioning provides neuroproteetion and increases vascular endothelial growth factor A, preserves the phosphorylation of Akt-Ser-473 and diminishes the increase in caspase-3 activity in neonatal rat hypoxic-ischemie model显示文摘 | Feng Y Rhodes PG Bhatt AJ | 2010 | Brain Res2010，1325，： | 1 |
| 14 | Neuroprotective effects of vascular endothelial growth factor following hypoxic ischemic brain injury in neonatal rats显示文摘 | Feng Y Rhodes PG Bhatt AJ | 2008 | Pediatr Res2008，64，4： | 1 |
| 15 | Tahyna virus and human infection, China 显示文摘 | Lu Z Lu XJ Fu SH Zhang S Li ZX Yao XH Feng YP Lambert AJ Ni DX Wang FT Tong SX Nasci RS Feng Y Dong Q Zhai YG Gao xY Wang HY Tang Q Liang GD | 2009 | Emerg Infect Dis2009，15，2： | 1 |
| 16 | Dexamethasone pre-treatment protects brain against hypoxic-ischemic injury partially through up-regulation of vascular endothelial growth factor A in neonatal rats显示文摘 | Feng Y Rhodes PG Bhatt AJ | 2011 | Neuroscience2011，179，14： | 1 |
| 17 | The regulation of ener' metabolism and the IGF- 1/mTOR pathways by the p53 protein 显示文摘 | Feng Z Levine AJ | 2010 | Trends Cell Biol2010，20，： | 1 |
| 18 | The coordinate regula- tion of the p53 and roTOR pathways in cells显示文摘 | Feng Z Zhang H Levine AJ | 2005 | Proc Natl Acad Sci USA2005，102，23： | 1 |
| 19 | The coordinate regulationof the p53 and mTOR pathways in cells显示文摘 | Feng Z Zhang H Levine AJ | 2005 | Proc Natl Acad SciU S A2005，102，23： | 1 |
| 20 | Ceordination and cemmunication between the p53 and IGF-1-AKT-TOR signal transduction pathways显示文摘 | Levine AJ Feng Z Mak TW | 2006 | Genes Dev2006，20，3： | 1 |
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