|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | DEC1 nuclear expression:A marker of differentiation grade in hepatocellular carcinoma显示文摘AIM: To investigate the expression patterns of human differentiated embryo chondrocyte 1 (DEC1) in hepatocellular carcinoma (HCC) and corresponding adjacent non-tumor and the normal liver tissues, the association between DEC1 expression and histopathological variables and the role of DEC1 in hepatocarcinogenesis. METHODS: The expression of DEC1 was detected immunohistochemically in 176 paraffin-embedded sections from 63 patients with HCC and 50 subjects with normal liver tissues. RESULTS: DEC1 protein was persistently expressed in the cytoplasm of hepatocytes in normal liver and HCC tissues. Compared with adjacent non-tumor liver tissues, HCC tissues showed high nuclear expression of DEC1 protein. However, high DEC1 nuclear expression was more frequently detected in well-differentiated (83.3%) than in moderately (27.3%) and poorly differentiated HCC (16.7%). Low DEC1 expression was associated with poor histological differentiation and malignancy progression. A correlation was found between the nuclear expression of DEC1 protein and histological differentiation (r = 0.376, P = 0.024). CONCLUSION: DEC1 is expressed in the cytoplasm of hepatocytes and because nuclear DEC1 expression is decreased with decreasing differentiation status of HCC, nuclear DEC1 might be a marker of HCC differentiation. | Xiao-Hong Shi Yan Zheng Qing Sun Jing Cui Qing-Hua Liu Fei Qü Yun-Shan Wang | 2011 | World Journal of Gastroenterology2011，17，15： | 15 |
| 2 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 3 | Micromorphology and phase behavior of cationic polyurethane segmented copo- lymer modified with hydroxysilane显示文摘 | WANG H H SHEN Y D FEI G Q | 2008 | Journal of Colloid and Interface Science2008，324，12： | 1 |
| 4 | MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration显示文摘 | Ma J Wang Q Fei T | 2007 | Blood2007，109，3： | 1 |
| 5 | Isolation of a strain of Acidithiobacillus caldus and its role in bioleaching of chalcopyrite显示文摘 | ZHOU Q G BO F BO Z H XI L JIAN G FEI L F HUA C X | 2007 | World Journal of Microbiology and Biotechnology2007，23，9： | 1 |
| 6 | Reliable H∞ Filtering for Discrete-Time Switched Singular Systems with Time-Varying Delay 显示文摘 | Lin J X Fei s M Wu Q | 2012 | Circuits Systems and Signal Processing2012，31，3： | 1 |
| 7 | MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration显示文摘 | Ma J Wang Q Fei T | 2007 | Blood2007，109，3： | 1 |
| 8 | Novel radiosynthesis of PET HSV-tk gene reporter probes FHPG and FHBG employing dual Sep-Pak SPE techniques 显示文摘 | Wang J Q Zheng Q H Fei X S | 2003 | Bioorg Med Chem Lett2003，13，22： | 1 |
| 9 | Preparation and Properties of Castor Oil/Pentaerythritol Triacy- late-based UV Curable Waterborne Polyurethane Ac- rylate 显示文摘 | LI K B SHEN Y D FEI G Q | 2015 | Prog in Org Coatings''2015，78，： | 1 |
| 10 | MicroRNA-638 inhibits cell prolifera- tion,invasion and regulates cell cycle by targeting tetraspanin 1 in human colorectal carcinoma 显示文摘 | Zhang J Fei B Wang Q | 2014 | Oncotarget2014，23，12： | 1 |
| 11 | QoS Routing based on genetic algorithm显示文摘 | FEI X LUO J Z WU J Y GU Q Q | 1999 | Computer Communications1999，22，9： | 1 |
| 12 | Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling显示文摘 | Fu S Fei Q Jiang H | | 0，，11： | 1 |
| 13 | Energy consumption-economic growth relationship and carbon dioxide emissions in China显示文摘 | Fei L Dong S Xue L Liang Q Yang W | 2011 | Energy Policy2011，39，2： | 1 |
| 14 | Astilbin inhibits contact hypersensitivity through negativecytokine regulation distinct from cyclosporin 显示文摘 | Fei M J Wu X F Xu Q | 2005 | Journal of Allergy and Clinical Immunology2005，116，： | 1 |
| 15 | MieroRNA directs mRNA cleavage of the transcription factor NAC1 to downregaulate auxin signals for Arabidopsis lateral root development显示文摘 | GUO H XIE Q FEI J CHUA N | 2005 | Plant Cell2005，17，： | 1 |
| 16 | Boundary layer wind structure from observation on a 325 m tower显示文摘 | Q S Li Lunhai Zhi Fei Hu | 2010 | Journal of Wind Engineering and Industrial Aerodynamics2010，98，12： | 1 |
| 17 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 18 | Challenging combination of CO2 geological storage and coal mining in Ordos Basin, China显示文摘 | LI Q FEI W LIU X | 2014 | Greenhouse Gases: Science and Technology2014，4，4： | 1 |
| 19 | Adhesion to fibronectin induces p27 (Kip1) nuclear accumulation through down-regulation of Jab1 and contributes to cell adhesion-mediated drug resistance (CAM-DR) in RPMI 8,226 cells 显示文摘 | FEI M HANG Q HOU S | 2014 | Mol Cell Biochem2014，386，12： | 1 |
| 20 | Preparation and properties of castor oil/pentaerythritol triacrylate-based UV curable waterborne polyurethane acrylate显示文摘 | LI K B SHEN Y D FEI G Q | 2015 | Progress in Organic Coatings2015，78，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员