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469篇 您的检索式：作者名="F M Gordon"

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	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	Novel approach to nonlinear non-Gaussian Bayesian state estimation显示文摘	Gordon N J Salmond D J Smith A F M	1993	IEE Proceedings-F1993，140，2：	2
3	Novel approach to non-finear/non-Gnussian Bayesian state estimation显示文摘	N J Gordon D J Salmond A F M Smith	1993	IEE Proceedings-F1993，140，2：	1
4	Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘	Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G	1998	Nature1998，393，：	1
5	Using genetic algorithms for concept learning显示文摘	DE JONG K A SPEARS W M GORDON F D	1993	Machine Learning1993，13，：	1
6	Novel Ap- proach to Nonlinear/non-Gaussian Bayesian State Estimation显示文摘	Gordon N J Salmond D J Smith A F M	1993	lEE Proceedings-F1993，140，2：	1
7	Novel approach to nonlinear/non-Gaussian Bayesian state estimation显示文摘	GORDON N J SALMOND D J SMITH A F M	1993	IEE Proceedings on Radar and Signal Processing1993，140，2：	1
8	Novel ap-proach to nonlinear/non-gaussian bayesian state esti-mation显示文摘	Gordon N J Salmond D J Smith A F M	1993	IEE Proceedings on Radar and SignalProcessing1993，140，2：	1
9	A novel approach to nonlinear1 non-gaussian bayesian state estimatior显示文摘	Gordon N J Salmond D J Smith A F M		0，，：	1
10	Integrated con- trol methodologies for road vehicles 显示文摘	Gordon T Howell M Brandao F	2003	Vehicle System Dynamics2003，40，1：	1
11	Novel Approach to Nonlinear/Non-Gaussian Bayesian State Est-Imation显示文摘	Gordon N J Salmond D J Smith A F M	1993	IEEE Proceedings-F1993，140，2：	1
12	Novel approach to nonlinear/non-Gaussian Bayesian state estimation显示文摘	Salmond D J Smith A F M		IEE Procedings F0，1993，：	1
13	Novel Approach to Nonlinear/Non-Gaussian Bayesian State Estimation显示文摘	GORDON N J SECOND D J SgITH A F M	1993	IEEE Proceeding-F1993，140，02：	1
14	Novel approach to nonlinear/non-gaussian bayesian state estimation显示文摘	GORDON N J SALMOND D J SMITH A F M	1993	IEE Proceedings -F1993，140，2：	1
15	Novel approach to nonlinear/non-Gaussian Bayesian state estimation 显示文摘	GORDON N SAI2cIOND D J SM1TH A F M	1993	IEEE Proceedings F Radar and Signal Processing1993，140，2：	1
16	Novel approach to non- linear/non gaussian bayesian state estimation显示文摘	Gordon N J Salmond D J Smith A F M	2002	IEE Procee- dings F In Radar and Signal Processing2002，140，2：	1
17	An experimental study of the variation of wettability of SMDs using the micro-global wetting method 显示文摘	Sargent P M Tang A C T Gordon F H	1991	IEEE/CHMT''91 IEMT Syrups1991，，：	1
18	Novel approach to non- linear/non-Gaussian Bayesian state estimation显示文摘	Gordon N J Salmond D J Smith A F M	1993	IEE Proc F1993，140，：	1
19	Novel approach 'to nonlinear / non-Gaussian Bayesian state estimation显示文摘	Gordon N J Salmond D J Smith A F M	1993	IEE Proceedings-F1993，140，2：	1
20	Novel approach to nonlinear/non-Gaussian Bayesian state estimation 显示文摘	GORDON N SALMOND D SMITH A F M	1993	IEE Proceeding F Radar Signal Process1993，140，：	1

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