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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Diuretics:1,2,4-Benzothiadiazine-1,1-Dioxides显示文摘 | NoveUo F C Bell S C Abram s E L A | 1960 | J Org Chem1960，25，6： | 1 |
| 3 | Isolation of thermophiles from broadleaf tobacco and effect of pure culture inoculation on cigar aroma and mildness显示文摘 | English C F Bell E J Berger A J | 1967 | Application Microbiology1967，15，： | 1 |
| 4 | Rep-PCR-mediated genomic fingerprinting:a rapid and effective method to identify Clavibacter michiganensis显示文摘 | Louws F J Bell J Medina-Mora C M | 1998 | Phytopathology1998，88，： | 1 |
| 5 | In-plane vibration of annular rings显示文摘 | Ambati G Bell J F W Sharp J C K | 1976 | Journal of Sound and Vibration1976，47，： | 1 |
| 6 | Isolation of thermophiles from brood leaf tobacco and effect of pure ulture inoculation on cigar aroma and mildness显示文摘 | English C F Bell E J Berger A J | 1967 | Ape Microbio1967，，15： | 1 |
| 7 | BirA En- zyme: Production and Application in the Study of Mem- brane Receptor - Ligand Interactions by Site-Specific Biotinylation Original Research 显示文摘 | O'Callaghan C A Byford M F Wyer J R Willcox BE Jakobsen B K McMichael A J Bell J 1 | 1999 | Anal Biochem1999，266，1： | 1 |
| 8 | Cooperative Catalyst Effects in Palladium-Mediated Cyanation Reactions of Aryl Halides and Triflates 显示文摘 | Anderson B A Bell E C Ginah F O | 1998 | J Org Chem1998，63，23： | 1 |
| 9 | Isolation of thermopiles from roadleaftobacco and effect of pure culture inoculation on cigar aroma and mildness显示文摘 | ENGLISH C F BELL E J BERTER A J | 1967 | Appl Envirorr Miembio1967，15，1： | 1 |
| 10 | Eosinophilic granuloma:a different behaviour in children than in adults显示文摘 | Plasschaert F Craig C Bell R | 2002 | J Bone Joint Surg Br2002，84，6： | 1 |
| 11 | A stochastic user equilibrium path flow estimator 显示文摘 | Bell M G H Shield C M Busch F | 1997 | Transporta- tion Research Part C: Emerging Technologies1997，5，34： | 1 |
| 12 | Shifts in the statistics of daily rainfall in South America conditional on ENSO phase 显示文摘 | Ropelewski C F Bell M A | 2008 | J Climate2008，21，： | 1 |
| 13 | The application of broadband ultrasonic spectroscopy to the study of layered media 显示文摘 | Haines N F Bell J C Mclntyre P J | 1978 | The Journal of the Acoustical Society of America1978，64，6： | 1 |
| 14 | Isolation of thermophiles from broadleaf tobacco and effect of pure culture inoculation on cigar aroma and mildness 显示文摘 | ENGLISH C F BELL E J BERGER A J | 1967 | Applied Microbiology1967，15，1： | 1 |
| 15 | The extracellular release of HMGB1 during apoptotie cell death显示文摘 | Bell C W Jiang W Reich C F 3 rd Pisetsky D S | 2006 | Am J Physiol Cell Physiol2006，291，： | 1 |
| 16 | Effects of forest floor disturbances by mechanical site preparation on floristic diversity in a central Ontario clearcut显示文摘 | Newmaster S G Parker W C Bell F W | 2007 | Forest Ecology and Management2007，246，： | 1 |
| 17 | New capabili- ties and methods of the X-12-ARIMA seasonal-adjust- ment program显示文摘 | Findley D F Monsell B C Bell W R | 1998 | Journal of Business & Economic Statis- tics1998，16，2： | 1 |
| 18 | Isolation of thermophiles from Broadieaf tobacco and effect of pure coulture inoculation on cigar aroma and mildness显示文摘 | Eglish C F Bell E J Berger A J | 1967 | Appl Microbio1967，，15： | 1 |
| 19 | Uptake of amino acids and ammonia at mid- gestation by the fetal lamb 显示文摘 | BELL A W KENNAUGH J M BATTAGLIA F C | 1989 | Q J Exp Physiol1989，74，5： | 1 |
| 20 | The overbasing of detergent additives:behaviour of promoters and determination of factors controlling the overbasing reaction显示文摘 | Belle C Gallo R Jacquet F | 1992 | Lubrication Science1992，4，5： | 1 |
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