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| 1 | Consensus statement on the epidemiology,diagnosis,prevention,and management of cow's milk protein allergy in the Middle East:a modified Delphi-based study显示文摘Background This study aimed to develop an expert consensus regarding the epidemiology,diagnosis,and management of cow’s milk protein allergy(CMPA)in the Middle East.Methods A three-step modified Delphi method was utilized to develop the consensus.Fifteen specialized pediatricians participated in the development of this consensus.Each statement was considered a consensus if it achieved an agreement level of>80%.Results The experts agreed that the double-blind placebo-controlled oral challenge test(OCT)should be performed for 2-A weeks using an amino acid formula(AAF)in formula-fed infants or children with suspected CMPA.Formula-fed infants with confirmed CMPA should be offered a therapeutic formula.The panel stated that an extensively hydrolyzed formula(eHF)is indicated in the absence of red flag signs.At the same time,the AAF is offered for infants with red flag signs,such as severe anaphylactic reactions.The panel agreed that infants on an eHF with resolved symptoms within 2-4 weeks should continue the eHF with particular attention to the growth and nutritional status.On the other hand,an AAF should be considered for infants with persistent symptoms;the AAF should be continued if the symptoms resolve within 2-4 weeks,with particular attention to the growth and nutritional status.In cases with no symptomatic improvements after the introduction of an AAF.other measures should be followed.The panel developed a management algorithm,which achieved an agreement level of 90.9%.Conclusion This consensus document combined the best available evidence and clinical experience to optimize the management of CMPA in the Middle East. | Moustafa A.El-Hodhod Mortada H.F.El-Shabrawi Ahmed AIBadi Ahmed Hussein AM Almehaidib Basil Nasrallah Ebtsam Mohammed AIBassam Hala El Feghali Hasan M.Isa Khaled Al Saraf Maroun Sokhn Mehdi Adeli Najwa Mohammed Mousa Al-Sawi Pierre Hage Suleiman Al-Hammadi | 2021 | World Journal of Pediatrics2021，17，6： | 3 |
| 2 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 3 | The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls显示文摘 | Moreira LO El Kasmi KC Smith AM | 2008 | Cell Microbiol2008，10，10： | 1 |
| 4 | Node count and groin recurrence in early vulvar cancer:a gynecologic oncology group study显示文摘 | STROUP AM HARLAN LC TRIMBLE EL | 2008 | Gynecol Oncol2008，108，3： | 1 |
| 5 | Myofibroblast phenotypes expression in experimental renal scarring显示文摘 | Muchaneta-Kubara EC el Nahas AM | 1997 | Nephrol Dial Transplant1997，12，5： | 1 |
| 6 | The use of minocycline-rifampin coated central venous catheters for exchange of catheters in the setting of staphylococ- cus aureus central line associated bloodstream infections显示文摘 | Chaftari AM El Zakhem A Jamal MA | 2014 | BMC Infect Dis2014，24，： | 1 |
| 7 | When is steatosis too much for transplantation?显示文摘 | NOCITO A EL - BADRY AM CLAVIEN PA | 2006 | J Hepatol2006，45，4： | 1 |
| 8 | Single-center review of fluoroscopy-guided percutaneous nephrostomy performed by uro- logic surgeons 显示文摘 | RANA AM ZAID1 Z EL -KHALID S | 2007 | J Endourol2007，21，： | 1 |
| 9 | Platelet turnover in stable corn- nary artery disease - influence of thrombopoietin and low-grade in- flammation 显示文摘 | Larsen SB Grove EL Hvas AM | 2014 | PLoS One2014，9，85： | 1 |
| 10 | Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kipl induces cell migration 显示文摘 | Vocero Akbani AM Snyder EL | 1998 | Nat Med1998，4，12： | 1 |
| 11 | First results of triple-modality treatment combining radiotherapy, chemotherapy, and hyperthermia for the treatment of patients with stage IIB, Ⅲ, and IVA cervical carcinoma显示文摘 | Westermann AM Jones EL Schem BC | 2005 | Cancer2005，104，4： | 1 |
| 12 | The influence of St John's wort on CYP2C19 activity with respect to genotype显示文摘 | Wang LS Zhu B El -Aty AM | 2004 | J Clin Pharmacol2004，44，： | 1 |
| 13 | Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kipl induces cell migration显示文摘 | Nagahara H Vocero-Akbani AM Snyder EL | 1998 | Nature Med1998，4，： | 1 |
| 14 | VEGF and diabetic microvaseular complieations显示文摘 | Muchaneta-Kubara EC el Nahas AM | 1997 | Nephrol Dial Transplant1997，12，： | 1 |
| 15 | The role of growth factors indiabetic peripheral neuropathy显示文摘 | Leinninger GM Vincent AM Feldman EL | 2004 | PeripherNervSyst2004，9，1： | 1 |
| 16 | Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood显示文摘 | Edghill EL Flanagan SE Patch AM | 2008 | Diabetes2008，57，4： | 1 |
| 17 | No evidence for point mutation in codons 12, 13 and 61 of the ras gene in a high incidence area for esophageal and gastric cancer显示文摘 | Victor T Du Toit R Jordaan AM el at | 1990 | Cancer Res1990，50，16： | 1 |
| 18 | Immature platelets in patients with acute coronary syndromes显示文摘 | Grove EL Hvas AM Kristensen SD | | 0，，1： | 1 |
| 19 | Single-center review of fluoroscopy-guided percutaneous nephrostomy performed by urologic surgeons 显示文摘 | RANA AM ZAIDI Z EL KHALID S | 2007 | J Endourol2007，21，7： | 1 |
| 20 | Genetic animal models for absence epilepsy:a review of the WAG/Rij strain of rats显示文摘 | Van Luijtelaar EL | 2003 | Behav Genet2003，33，6： | 1 |
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