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| 1 | The DNA-binding factor Ctcf critically controls gene expression in macrophages显示文摘巨噬细胞在免疫和动态平衡起一个重要作用。在经由特定的受体的病原体识别之上,他们很快导致煽动性的回答。这个过程紧在 transcriptional 水平被控制。DNA 有约束力的锌手指蛋白质 CCCTC 有约束力的因素(Ctcf ) 是远程的染色质相互作用的一个关键管理者并且协调在抄写因素和基因表达式进程之间的特定的通讯。在这研究, Ctcf 基因被使用转基因的 Cre-LoxP 系统明确地在 myeloid 房间删除。在 myeloid 房间的 Ctcf 基因的有条件的删除在 vivo 导致了温和显型。显著地展出的 Ctcf 缺乏的老鼠减少了主要 histocompatibility 的表示在肝的建筑群(MHC ) 班 II。Ctcf 缺乏的巨噬细胞表明了正常表面显型和吞噬作用能力。在像使用费的受体(TLR ) 之上刺激,他们生产了支持 inflammatory cytokines IL-12 和 IL-6 的正常层次,但是表明了一个强烈损害的能力生产肿瘤坏死因素(TNF ) 和 IL-10,以及表示 IL-10 家庭成员 IL-19, IL-20 和 IL-24。一起拿,我们的数据表明涉及巨噬细胞功能调整的 Ctcf 的一个角色。 | Tatjana Nikolic Dowty Movita Margaretha EH Lambers Claudia Ribeiro de Almeida] Paula Biesta Kim Kreefft Marjolein JW de Bruijn Ingrid Bergen Niels Galjart Andre Boonstra Rudi Hendriks | 2014 | Cellular & Molecular Immunology2014，11，1： | 2 |
| 2 | Vascularity in asthmatic airways: relation to inhaled steroid dose 显示文摘 | Orsida BE Li X Hickey B Thien F Wilson JW Waiters EH | 1999 | Thorax1999，54，4： | 1 |
| 3 | Opitmal age and re-subs in repair of large ventfieular septal defects 显示文摘 | J Blackstone EH Kirklin JW Bradley EL | 1976 | Thorac Cardio-vase Surg1976，72，： | 1 |
| 4 | Clinical and electro-myograpnic studies in a patient with primary hypokalemic periodic paralysis显示文摘 | ENGEL AG LAMBERT EH ROSEVEAR JW | 1965 | Am J Med1965，38，： | 1 |
| 5 | Optimal age and resuits in repair of large ventricular septal defect显示文摘 | Blackstone EH Kirkklin JW Bradley EL | 1976 | J Thorac Cardiovase Surg1976，72，5： | 1 |
| 6 | Preoperative predicti on from cineangiograms of postrepair right ventricular pressure in tetralogy of Fal ot显示文摘 | Blackstone EH Kirklin JW Bertranou EG | | 0，，04： | 1 |
| 7 | Usefulness of albuminuria as predictor for coronary artery stenosis,regardless of estimated glomerular filtration rate,in patients with type 2 diabetes mellitus 显示文摘 | Son JW Jang EH Kim MK | 2012 | Am J Cardiol2012，110，10： | 1 |
| 8 | Relationship of brain blood flow and oxygen consumption to perfusion flow rates during profoundly hypothermic cardiopulmonary bypass 显示文摘 | Blackstone EH Kirklin JW | 1984 | J Thorac Cardiovasc Surg1984，87，： | 1 |
| 9 | Effects of iontophoretically applied substance P, calchon in gene-related peptide on excitability of dorsal horn neurons in rats显示文摘 | Leem JW Gwak YS Lee EH | 2001 | Yonsei Med J2001，42，： | 1 |
| 10 | The effectiveness of depression care management on diabetes related outcomes in older patients显示文摘 | Williams JW Katon W Lin EH | 2004 | Ann Intern Med2004，140，12： | 1 |
| 11 | Laparoscopic-assisted and minilaparotomy approaches to colorectal diseases are similar in early outcome显示文摘 | Fleshman JW Fry RD Birnbaum EH | 1996 | Dis Colon Rectum1996，39，1： | 1 |
| 12 | Replication of Epstein-Barr virus in human epithelial cells infected in vitro显示文摘 | Sixbey JW Vesterinen EH Nedrud JG | 1983 | Nature1983，306，： | 1 |
| 13 | Medical predictors for psychopathology in adults with operated congenital heart disease显示文摘 | van Rijen EH Utens EM Roos-Hesselink JW | 2004 | Eur Heart J2004，25，： | 1 |
| 14 | Cooperative E - box regulation of human GLI1 by TWIST and USF显示文摘 | Villavicencio EH Yoon JW Frank D J | 2002 | Genesis2002，32，4： | 1 |
| 15 | Surgical Management of Pulmonary Artery in Technology of Fallout显示文摘 | Kirilin JW Blackstone EH | 1997 | J Thorac Cardiovase Surg1997，74，： | 1 |
| 16 | Quality of life after perimesencephalic haemorrhage显示文摘 | Hop JW | 1997 | J Neurol Neurasurg Psychiatry1997，63，： | 1 |
| 17 | Altered regulation of renin-angiotensin, endothelin and natriuretic peptide systems in rat kidney with chronic unilateral ureteral obstruction显示文摘 | Bae EH Kim IJ Park JW | 2007 | Urol Int2007，79，2： | 1 |
| 18 | Renoprotective effect of rosuvastatin in DOCA-salt hypertensive rats 显示文摘 | BAE EH KIM IJ PARK JW | 2010 | Nephrol Dial Transplant2010，25，4： | 1 |
| 19 | Decision-making in the repair of tetralogy of Fallot based on intraoperative measurements of the pulmonary arterial outflow tract显示文摘 | Blackstone EH Kirklin JW Pacifico AD | 1977 | J Thorac Cardiovasc Surg1977，77，8： | 1 |
| 20 | Acute and chronic effects of transient myocardial ischemic on sympathetic nerve activity, density, and norepinephrine content显示文摘 | O'Connell JW Botvinick EH | 1995 | Cardiovasc Res1995，30，2： | 1 |
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