|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pediatric functional constipation treatment with Bifi dobacterium-containing yogurt:A crossover,double-blind,controlled trial显示文摘AIM: To evaluate the treatment of pediatric functional chronic intestinal constipation (FCIC) with a probiotic goat yogurt. METHODS: A crossover double-blind formula-controlled trial was carried out on 59 students (age range: 5-15 years) of a public school in Belo Horizonte, MG, Brazil, presenting a FCIC diagnostic, according to Roma Ⅲ criteria. The students were randomized in two groups to receive a goat yogurt supplemented with 109 colony forming unit/mL Bifidobacterium longum (B.longum) (probiotic) daily or only the yogurt for a period of 5 wk (formula). Afterwards, the groups were intercrossed for another 5 wk. Defecation frequency, stool consistency and abdominal and defecation pain were assessed.RESULTS: Both treatment groups demonstrated improvement in defecation frequency compared to baseline. However, the group treated with probiotic showed most signif icant improvement in the f irst phase of the study. An inversion was observed after crossing over, resulting in a reduction in stool frequency when this group was treated by formula. Probiotic and formula improved stool consistency in the f irst phase of treatment, but the improvement obtained with probiotic was significantly higher (P = 0.03). In the second phase of treatment, the group initially treated with probiotic showed worseningstool consistency when using formula. However, the difference was not signif icant. A signif icant improvement in abdominal pain and defecation pain was observed with both probiotic and formula in the first phase of treatment, but again the improvement was more signif icant for the group treated with B. longum during phase I (P < 0.05). When all data of the crossover study were analyzed, significant differences were observed between probiotic yogurt and yogurt only for defecation frequency (P = 0.012), defecation pain (P = 0.046) and abdominal pain (P = 0.015). | Paula VP Guerra Luiza N Lima Tassia C Souza Vanessa Mazochi Francisco J Penna Andreia M Silva Jacques R Nicoli Elizabet V Guimares | 2011 | World Journal of Gastroenterology2011，17，34： | 25 |
| 2 | 定期运动有助于改善高血压患者蛋白质稳态、炎症和血管活性显示文摘体育锻炼是一种公认的非药物控制血压的策略,除了降低血压外,运动还能对高血压患者的炎症特征、自主功能、内皮功能和抗氧化状态产生积极的影响。但其对高血压患者的蛋白质稳态的影响尚不清楚。已有动物研究表明,运动训练干预可以改善蛋白质质量控制机制,但在动物模型中报告的积极作用仍有待于在人类身上得到证实。本研究旨在根据报告的运动习惯,评估患高血压成年人的蛋白质稳态,生活质量以及炎症、氧化应激和血管活性生物标记物状态。 | Teixeira M Gouveia M Duarte A Ferreira M Simões MI Conceição M Silva G Magalhães S Ferreira R Nunes A Vieira SI Ribeiro F 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Preemptive ketamine decreases postoperstive narcotic requirements in patients undergoing abdominal aurgery显示文摘 | Miguel R Scharf JE | 1997 | Anesth Analg1997，84，5： | 1 |
| 5 | Procalcitonin assay in systemic inflammation,infection, and sepsis: clinical utility and limitations 显示文摘 | Becker KL Snider R Nylen ES | 2008 | Crit Care Med2008，36，： | 1 |
| 6 | The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men: a novel demonstration显示文摘 | Epel ES Merkin SS Cawthon R | 2009 | Aging2009，1，1： | 1 |
| 7 | Flexible ureterorenoscopy and holmium laser lithotripsy for management of renal stone burdens that measure 2 to 3 cm: a multi-institutional experience 显示文摘 | Hyams ES Munver R Bird VG | 2010 | J Endourol2010，24，10： | 1 |
| 8 | Donor-Site morbidity of the radial forearm free flap versus the ulnar forearm free flap显示文摘 | Hekner DD Abbink JH van Es R J | 2013 | Plast Reconstr Surg2013，132，2： | 1 |
| 9 | Tumor-expressed B7-H1 and B7-DC in relation to PD-1 + T-cell infiltration and survival of patients with cervical carcinoma 显示文摘 | Karim R Jordanova ES Piersma SJ | 2009 | Clin Cancer Res2009，15，20： | 1 |
| 10 | Procalcitonin in sepsis and systemic inflammation:a harmful biomarker and a therapeutic target显示文摘 | Becker KL Snider R Nylen ES | 2010 | Br J Pharmacol2010，159，2： | 1 |
| 11 | Transient ischemic attacks in rural and urban northern Portugal:incidence and short - term prognosis 显示文摘 | Correia M Silva MR Magalh'~es R | 2006 | Stroke2006，37，1： | 1 |
| 12 | Pmcalcitonin in sepsis and sys - temic inflammation: a harmful biomarker and a therapeutic target 显示文摘 | Becker KL Snider R Nylon ES | 2010 | Br J Pharmae2010，159，2： | 1 |
| 13 | A study of KMeans-based algorithms for constrained clustering显示文摘 | Coves Thiago F Hruschka Eduardo R | 2013 | Intelligent Data Analysis2013，17，3： | 1 |
| 14 | Nontreponemal tests in the diagnosis of neurosyphilis: an evaluation of the Venereal Disease Research Laboratory (VDRL) and the Rapid Plasma Reagin (RPR) tests显示文摘 | Castro R Prieto ES da Luz Martins Pereira F | 2008 | J Clin Lab Anal2008，22，4： | 1 |
| 15 | Inclusion of the herpes simplex thymidine kinase gene in a replicating adenovirus does not augment antitumor efficacy显示文摘 | Lambright ES Amin K Wiewrodt R | 2001 | Gene Ther2001，8，： | 1 |
| 16 | Evaluation of an enzyme immunoassay technique for detection of antibodies against Treponema pallidum 显示文摘 | Castro R Prieto ES Santo I | 2003 | J Clin Microbiol2003，41，1： | 1 |
| 17 | Caught up in a Wnt storm~ Wnt signaling in cancer显示文摘 | Giles R H van Es J H Clevers H | 2003 | Biochim Biophys Acta2003，1653，： | 1 |
| 18 | Marfan syndrome Long-term survivsl and Complications after arotic aneurysm repair显示文摘 | Pink bohner R Johnston D Crawford ES | 1995 | Circulation1995，91，5： | 1 |
| 19 | WHO-EORTC classification for cutaneous lymphomas显示文摘 | Willemze R Jaffe ES Burg G | 2005 | Blood2005，105，10： | 1 |
| 20 | Metropolitan suburbanization and central city problems 显示文摘 | MILLS ES Price R | 1984 | Journal of Urban Economics1984，15，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员