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| 1 | Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression显示文摘AIM: To evaluate the effect of resveratrol, alone and in combination with fenofibrate, on fructose-induced metabolic genes abnormalities in rats. METHODS: Giving a fructose-enriched diet(FED) to rats for 12 wk was used as a model for inducing hepatic dyslipidemia and insulin resistance. Adult male albino rats(150-200 g) were divided into a control group and a FED group which was subdivided into 4 groups, a control FED, fenofibrate(FENO)(100 mg/kg), resveratrol(RES)(70 mg/kg) and combined treatment( FENO + RES)( half the doses). A l l treatments were given orally from the 9th week till the end of experimental period. Body weight, oral glucose tolerance test(OGTT), liver index, glucose, insulin, insulin resistance(HOMA), serum and liver triglycerides(TGs), oxidative stress(liver MDA, GSH and SOD),serum AST, ALT, AST/ALT ratio and tumor necrosis factor-α(TNF-α) were measured. Additionally, hepatic gene expression of suppressor of cytokine signaling-3(SOCS-3), sterol regulatory element binding protein-1c(SREBP-1c), fatty acid synthase(FAS), malonyl Co A decarboxylase(MCD), transforming growth factor-β1(TGF-β1) and adipose tissue genes expression of leptin and adiponectin were investigated. Liver sections were taken for histopathological examination and steatosis area were determined.RESULTS: Rats fed FED showed damaged liver, impairment of glucose tolerance, insulin resistance, ox ida t ive s t re s s a nd dy s l ipide m ia. As fo r ge ne expression, there was a change in favor of dyslipidemia and nonalcoholic steatohepatitis(NASH) development. All treatment regimens showed some benefit in reversing the described deviations. Fructose caused deterioration in hepatic gene expression of SOCS-3, SREBP-1c, FAS, MDA and TGF-β1 and in adipose tissue gene expression of leptin and adiponectin. Fructose showed also an increase in body weight, insulin resistance(OGTT, HOMA), serum and liver TGs, hepatic MDA, serum AST, AST/ALT ratio and TNF-α compared to control. All treatments improved SOCS-3, FAS, MCD, TGF-β1 and leptin genes expression while only RES and FENO + RES groups showed an improvement in SREBP-1c expression. Adiponectin gene expression was improved only by RES. A decrease in body weight, HOMA, liver TGs, AST/ALT ratio and TNF-α were observed in all treatment groups. Liver index was increased in FENO and FENO + RES groups. Serum TGs was improved only by FENO treatment. Liver MDA was improved by RES and FENO + RES treatments. FENO + RES group showed an increase in liver GSH content.CONCLUSION: When resveratrol was given with half the dose of fenofibrate it improved NASH-related fructose-induced disturbances in gene expression similar to a full dose of fenofibrate. | Enas A Abd El-Haleim Ashraf K Bahgat Samira Saleh | 2016 | World Journal of Gastroenterology2016，22，10： | 5 |
| 2 | Seizure classification in EEG signals utilizing Hilbert-Huang transform显示文摘 | Rami J O Enas W A | 2011 | Biomedical Engineering Online2011，10，1： | 1 |
| 3 | Amblyopia screening for first and second-grade children in Jordan显示文摘AIM:To share the results of a national screening program for amblyopia in school children in the north of Jordan.METHODS:This is a prospective national screening study for amblyopia.The program rolls first and second-grade children(6 to 7 years old) in the north of Jordan.The eye examination included:best-corrected visual acuity,cover-uncover test,and cycloplegic retinoscopy.Monocular visual acuity was tested using an ETDRS visual acuity chart without correction.Moreover,children were tested with full cycloplegic refraction when the test criteria were met.Unilateral amblyopia was defined as a best-corrected visual acuity difference of 2 or more lines.In comparison,bilateral amblyopia was defined as a best-corrected visual acuity of 20/40 or worse in the best eye.RESULTS:The prevalence of amblyopia for the total sample tested(n=17 203) was 2.78%(n=479).The most common cause of amblyopia was hypermetropia(64.45%),followed by previous ocular surgeries(15.1%),myopia(10.43%),strabismus(9.39%),and congenital cataract(0.63%).CONCLUSION:This is the first and only study,identifing modifiable risk factors in Jordanian children with amblyopia.In their first couple of years of elementary education,many Jordanian children are affected by amblyopia and pass unnoticed.A more governmental effort is needed into screening programs to improve vision in the Jordanian population. | Khalil M.Al-Salem Mohammad S.Saleem Ismat Ereifej Hamzeh M.Alrawashdeh Rayed Falah Hussein Obeidat Asma Ali Abdlmohdi Raeda Zaki Al-Momani Layal Mohammed Hammad Omar Ahmad al-Habahbeh Yaqeen M.Assassfeh Laith Ramzi Najib Al-Qsous Ashraf Hatim Adeeb Nasraween Tariq A.Al Maaitah Deya'-Aldin Muneer Hasan Aqeel Ibtehal Eyadeh Awad Alabdulrazzg Abdullah Mahmoud Mohammad Murad Amany Jehad Faleh AL-Zurqan Enas Jamal Mohammad Jaradat Slsabela Emad Suliman Aldhoon Ala'a Majed Dmour Ahmad Talal Asassfeh Jeries Ayman Halaseh Abdel Aziz Ammar Daoud Waha Ayman Alkasasbeh Kholoud GH.Matar | 2022 | International Journal of Ophthalmology(English edition)2022，15，2： | 1 |
| 4 | Application of an innovative methodology to improve the starting-up of UASB reactors treating domestic sewage显示文摘 | Rodriguez J A P ena M R Manzi V | 2001 | Water Science and Technology2001，44，4： | 1 |
| 5 | Assessment of the potential of Nastoc strains from Passteur Culture Collection for the produetion of polysaccharides of applied interest显示文摘 | De Philippis R Ena A Paperi R | 2000 | J Appl Phycol2000，12，： | 1 |
| 6 | Circulating leptin and insulin in obese patients with and without type 2 diabetes mellitus: Relation to ghrelin and oxidative stress 显示文摘 | ENAS A HAMED MADEHA M ZAKARY NAGWA S AHMED | 2011 | Diabetes ''Res Clinical Practice2011，94，3： | 1 |
| 7 | Reuse of waste iron as a partial replacement of sand in concrete显示文摘 | Zainab Z Ismail Enas A AL-Hashmi | | 0，，28： | 1 |
| 8 | Wheyprotein antigenicity reduction by fungal proteinases and apepsin/pancreatic combination显示文摘 | Ena J M Van Beresteijn E C H Robben A J P M | 1995 | Journal of Food Science1995，60，： | 1 |
| 9 | Elevated lipoprotein (a) --a genetic risk factor for premature vascular disease in people with and without standard risk factors: a review 显示文摘 | Enas EA Chacko V Senthilkumar A | 2006 | Dis Mon2006，52，1： | 1 |
| 10 | An investigational new drug treatment program for patients with gemcitabine:results for over 3000 patients with pancreatic carcinoma显示文摘 | Storniolo A M Enas N H Brown C A | 1999 | Cancer1999，85，6： | 1 |
| 11 | Reyes cortes, new optical mountings of the spectral devices with con- cave diffraction gratings and high entrance slit显示文摘 | E|ena Sokolova Santiago D A | 1996 | SHE1996，2863，： | 1 |
| 12 | Elevated lipoprotein (a)-a genetic risk factor for premature vascular disease in people with and without standard risk factors: a review 显示文摘 | Enas EA Chacko V Senthilkumar A | 2006 | Dis Mon2006，52，1： | 1 |
| 13 | Whey protein antigenicity reduction by fungal proteinases and a pepsin/ pancreatic combination显示文摘 | Ena J M Van Beresteijn E C H Robben A J P M | 1995 | Journal of Food Science1995，60，： | 1 |
| 14 | Passive sampling for long-term monitoring of organic pollutants in water显示文摘 | Agata Kot Bo?ena Zabiega?a Jacek Namie?nik | 2000 | Trends in Analytical Chemistry2000，，7： | 1 |
| 15 | Prevalence of and risk factors for hepatitis C in rural pregnant Egyptian women显示文摘 | Sonia K. Stoszek Mohamed Abdel-Hamid Shaker Narooz Mai El Daly Doa’a A. Saleh Nabiel Mikhail Enas Kassem Yousry Hawash Sherif El Kafrawy Ahmed Said Manal El Batanony Fatma M. Shebl Mohamed Sayed Soraya Sharaf Alan D. Fix G. Thomas Strickland | 2005 | Transactions of the Royal Society of Tropical Medicine and Hygiene2005，，2： | 1 |
| 16 | The metabolic syndrome anddyslipidemia among Asian Indians: a population with high rates of diabetes and premature coronary artery disease显示文摘 | ENAS E A MOHAN V DEEPA M | 2007 | J Cardiometab Syndr2007，2，4： | 1 |
| 17 | High-fidelity mRNA amplification for gene profiling显示文摘 | Ena W Lance D M Galen A O | 2000 | Nat Biotech2000，18，4： | 1 |
| 18 | Aninvestigational new drug treatment program for patients with gemcitabine:results for over 3000 patients with pancreatic carcinoma显示文摘 | STORNIOLO A M ENAS N H BROWN C A | 1999 | Cancer1999，85，6： | 1 |
| 19 | Whey protein antigenicity reduction by f~ngal protei- nases and a pepsin/pancreatic combination 显示文摘 | ENA J M VAN BERESTEIJN E C H ROBBEN A J P M | 1995 | Journal of Food Science1995，，60： | 1 |
| 20 | Potential involve ment of the IL-33-ST2 axis in the pathogenesis of pri mary Sjogren's syndrome显示文摘 | Awada A Nicaise C Ena S | 2014 | Annals of the Rheumatic Diseases2014，73，6： | 1 |
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