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| 1 | IL-10 and TNF-α promoter haplotypes are associated with childhood Crohn’s disease location显示文摘AIM: To determine the distribution and frequencies of the genotypes and haplotypes of the genes encoding for the glucocorticoid receptor (GR), the tumor necrosis factor (TNF)-α and the interleukin (IL)-10 in childhood Crohn’s disease (CD) and to assess the impact of the corresponding DNA variants on clinical and disease phenotypes. METHODS: Ten variants in GR, TNF-α and IL-10 were genotyped in 113 childhood CD cases and 95 healthy subjects, both of French-Canadian origin. RESULTS: For the GR polymorphisms (R23K and N363S) and IL-10 variants in the 5’flanking region (-1082 G > A, -819 T > C and -592 A > C), no difference was observed in allele and genotype frequencies between CD patients and controls. At the haplotype level, we found three IL-10 haplotypes previously described in Caucasians (GCC, ACC and ATA) and three novel haplotypes only present in IBD patients. When we analyzed the haplotype distribution with the anatomical location of the disease, the GCC haplotype was associated with the colonic and the ACC haplotype with the terminal ileum location, respectively. The genotyping of fi ve polymorphisms in the promoter region of the TNF-α gene (-1031 T > C, -863 A > C, -857 T > C, -308 A > G and -238 A > G) revealed a significant overrepresentation of homozygous -1031 CC among CD patients (OR = 9.9) and an association with the colonic location. For TNF-α, eleven haplotypes were inferred, including two frequent ones, TCCGG and CACGG, which were significantly observed more frequently in controls and cases, respectively.CONCLUSION: This is one of the fi rst studies investigating the association between haplotype structure and disease location in a CD pediatric cohort. Our results will help to increase our understanding of the genetic determinants of childhood CD. | Rocio Sanchez Emile Levy Florin Costea Daniel Sinnett | 2009 | World Journal of Gastroenterology2009，15，30： | 9 |
| 2 | Impact of Iron Loss on Behavior of Vector Con- trolled Induction Machines 显示文摘 | Emil Levi | 1995 | IEEE Transactions on Indus- try Applications1995，31，6： | 1 |
| 3 | Even-phase multi-motor vector controlled driver with single inverter supply and series connection of stator windings显示文摘 | Emil Levi | | 0，，05： | 1 |
| 4 | A review of RFO induction motor parameter estimation techniques显示文摘 | Hamid A Toliyat Emil Levi Mona Raina | 2003 | IEEE Transactions on Energy Conversion2003，18，2： | 1 |
| 5 | A review of RFO induction motor parameter estimation techniques 显示文摘 | Toliyat Hamid A Levi Emil Raina M | 2003 | IEEE Transactions on Energy Conversion2003，18，2： | 1 |
| 6 | A Review of RFO In-duction Motor Parameter Estimation Techniques显示文摘 | Hamid A Toliyat Emil Levi | 2003 | IEEE Transactions on Energy Conversion2003，18，2： | 1 |
| 7 | Multiphase Electric Machines for Variable-speed Applications 显示文摘 | Emil Levi | 2008 | IEEE Transactions on Industrial Electron- ics2008，55，5： | 1 |
| 8 | Multiphase electric machines for variable- speed applications显示文摘 | Emil Levi | 2008 | IEEE Transactions on Industrial Electronics2008，55，5： | 1 |
| 9 | A Review of RFO Induetion Motor Parameter Estimation Techniques 显示文摘 | Hamid A Toliyat Emil Levi Mona Raina | 2003 | IEEE Transactions on Energy Conversion2003，18，2： | 1 |
| 10 | An Enhanced Pre-dictive Current Control Method for Asymmetrical Six-Phase MotorDrives显示文摘 | Federico Barrero Joel Prieto Emil Levi | 2011 | IEEE Transactions on Industrial Electronics2011，58，8： | 1 |
| 11 | Impact of dynamic cross-saturation on accuracy of saturated synchronous machine models显示文摘 | Emil Levi Viktor A Levi | 2000 | IEEE Transactions on Energy Conversion2000，15，2： | 1 |
| 12 | A review of RFO induction motor parameter estimation techniques 显示文摘 | Toliyat Hamid A Levi Emil Raina Mona | 2003 | IEEE Transactions on Energy Conversion2003，18，2： | 1 |
| 13 | Impact of iron loss on behavior of vector controlled induction machines显示文摘 | Emil Levi | 1995 | IEEE Transactions on Industry Applications1995，31，6： | 1 |
| 14 | Transforming Growth Factor-β1 Mechanisms in Aortic Valve Calcification: Increased Alkaline Phosphatase and Related Events显示文摘 | Jocelyn N. Clark-Greuel Jeanne M. Connolly Elizabeth Sorichillo Navneet R. Narula H. Scott Rapoport Emile R. Mohler Joseph H. Gorman Robert C. Gorman Robert J. Levy | 2007 | The Annals of Thoracic Surgery2007，，3： | 1 |
| 15 | A stator resistance estimation scheme for speed sensorless rotor flux oriented induction motor drives显示文摘 | Vasic V Vukosavic S N Levi Emil | 2003 | IEEE Transactions on Energy Conversion2003，18，4： | 1 |
| 16 | A novel concept of a multi phase multi-motor vector controlled drive system sup- plied from a single voltage source inverter 显示文摘 | Emil Levi Martin Jones | 2004 | IEEE Trans on Power electronics2004，19，2： | 1 |
| 17 | Parallel-con- nected multiphase multi-drive systems with single inverter supply 显示文摘 | MARTIN J SLOBODAN N Vukosavic EMIL Levi | 2009 | IEEE Transactions on Industrial Electronics2009，56，6： | 1 |
| 18 | A Review of RFO Induc- tion Motor Parameter Estimation Techniques 显示文摘 | Hamid A Toliyat Emil Levi Mona Raina | 2003 | IEEE Transaction on Energy Conversion2003，18，2： | 1 |
| 19 | Muhiphase electric machines for variable - speed applications 显示文摘 | Emil Levi | 2008 | IEEE Transactions on Industry Applications2008，55，5： | 1 |
| 20 | A novel concept of a muhipase multimotor vector controlled drive system supplied from a single voltage source in- verter显示文摘 | Emil Levi Martin Jones Slobodan N | 2004 | IEEE Trans on Power electronics2004，19，2： | 1 |
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