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| 1 | Impact of diabetes mellitus on risk of cardiovascular disease and all-cause mortality: Evidence on health outcomes and antidiabetic treatment in United States adults显示文摘AIMTo examine the epidemic of diabetes mellitus (DM) and its impact on mortality from all-cause and cardiovascular disease (CVD), and to test the effect of antidiabetic therapy on the mortality in United States adults. METHODS The analysis included a randomized population sample of 272149 subjects ages ≥ 18 years who participated in the National Health Interview Surveys (NHIS) in2000-2009. Chronic conditions (hypertension, DM and CVD) were classified by participants’ self-reports of physician diagnosis. NHIS-Mortality Linked Files, and NHIS-Medical Expenditure Panel Survey Linkage Fileson prescribed medicines for patients with DM were used to test the research questions. χ 2, Poisson and Cox’s regression models were applied in data analysis.RESULTS Of all participants, 22305 (8.2%) had DM. The prevalence of DM significantly increased from 2000 to 2009 in all age groups (P < 0.001). Within an average 7.39 (SD= 3) years of follow-up, male DM patients had 1.56 times higher risk of death from all-cause (HR = 1.56, 95%CI:1.49-1.64), 1.72 times higher from heart disease [1.72 (1.53-1.93)], 1.48 times higher from cerebrovascular disease [1.48 (1.18-1.85)], and 1.67 times higher from CVD [1.67 (1.51-1.86)] than subjects without DM,respectively. Similar results were observed in females. In males, 10% of DM patients did not use any antidiabetic medications, 38.1% used antidiabetic monotherapy, and 51.9% used ≥ 2 antidiabetic medications. These corresponding values were 10.3%, 40.4% and 49.4% in females. A significant protective effect of metformin monotherapy or combination therapy (except for insulin) on all-cause mortality and a protective but non-significant effect on CVD mortality were observed. CONCLUSION This is the first study using data from multiple linkage files to confirm a significant increased prevalence of DM in the last decade in the United States. Patients with DM have significantly higher risk of death from all-cause and CVD than those without DM. Antidiabetic mediations,specifically for metformin use, show a protective effect against all-cause and CVD mortalities. | Longjian Liu Barbara Simon Jinggaofu Shi Arshpreet Kaur Mallhi Howard J Eisen | 2016 | World Journal of Diabetes2016，7，18： | 12 |
| 2 | 心血管疾病病死率与血清25-羟基维生素D浓度相关性研究显示文摘目的研究心衰死亡、心血管疾病死亡和过早死亡与血清25-羟基维生素D[25(OH)D]浓度的相关性。方法在第3次美国健康和营养调查中,1988~1994年为基线数据,纳入35岁以上参与者13 131名(男性6130名,女性7 001名),随访至2000年12月31日。结果随访8年期间,共有3 266人死亡(24.9%),其中心衰死亡101人,心血管疾病死亡1 451人,早死1 066人。心衰死亡者中有37%血清25(OH)D水平低于20ng/mL,非心衰死亡者为26%(P<0.001)。多元Cox模型显示,血清25(OH)D水平低于20ng/mL的心衰死亡风险是超过30ng/mL的2.06倍(95%CI:1.01~4.25)(P<0.001),过早死亡风险为1.40倍(95%CI:1.17~1.68;P<0.001);血清25(OH)D浓度20~29ng/mL的过早死亡风险是超过30ng/mL的1.11倍(95%CI:0.93~1.33)。结论血清25(OH)D水平不足的成年人死于心血管病、心衰和过早死亡的风险较高。 | 刘隆健 魏敏 陈明 Shelley R Hankins Ana E.Nùez Robert A Watson Perry J Weinstock Craig J.Newschaffer Howard J Eisen 邹强 杨书 陈卫中 | 2013 | 成都医学院学报2013，8，2： | 6 |
| 3 | Durability of Radiofrequency Ablation in Barrett’s Esophagus With Dysplasia显示文摘 | Nicholas J. Shaheen Bergein F. Overholt Richard E. Sampliner Herbert C. Wolfsen Kenneth K. Wang David E. Fleischer Virender K. Sharma Glenn M. Eisen M. Brian Fennerty John G. Hunter Mary P. Bronner John R. Goldblum Ana E. Bennett Hiroshi Mashimo Richard I | 2011 | Gastroenterology2011，，2： | 3 |
| 4 | Polyp Size and Advanced Histology in Patients Undergoing Colonoscopy Screening: Implications for CT Colonography显示文摘 | David Lieberman Matthew Moravec Jennifer Holub Leann Michaels Glenn Eisen | 2008 | Gastroenterology2008，，4： | 3 |
| 5 | A lexicon for endoscopic adverse events: report of an ASGE workshop显示文摘 | Peter B. Cotton Glenn M. Eisen Lars Aabakken Todd H. Baron Matt M. Hutter Brian C. Jacobson Klaus Mergener Albert Nemcek Bret T. Petersen John L. Petrini Irving M. Pike Linda Rabeneck Joseph Romagnuolo John J. Vargo | 2010 | Gastrointestinal Endoscopy2010，，3： | 3 |
| 6 | Intussusception in adults: institutional review 1 1 No competing interests declared.显示文摘 | Leon K Eisen John D Cunningham Arthur H Aufses | 1999 | Journal of the American College of Surgeons1999，，4： | 3 |
| 7 | 胶囊内镜与常规上消化道内镜检查诊断食管静脉曲张准确性的比较:一项前瞻性、3中心先导性研究显示文摘Background and study aims: Variceal bleeding is a major complication of cirrhosis, and is associated with a 20% mortality at 6 weeks. Current international guidelines recommend that patients with cirrhosis are screened by conventional upper endoscopy (esophagogastroduodenoscopy, EGD) in order to detect esophageal varices. The recently developed PillCam ESO esophageal capsule endoscope has been shown to be an accurate diagnostic tool in the investigation of patients with gastroesophageal reflux and Barrett’ s esophagus. We compared the PillCam ESO capsule endoscope with EGD for the detection of esophagogastric varices and portal hypertensive gastropathy in patients with cirrhosis. Patients and methods: A pilot trial was conducted at three sites. Patients with cirrhosis who were undergoing clinically indicated EGD for screening or surveillance for esophageal varices underwent a PillCam ESO study followed by an EGD within 48 hours. Capsule videos were assessed by an investigator who was blinded to the patient’ s medical history and EGD findings. Results: A total of 23 of the 32 enrolled patients were found to have esophageal varices at both EGD and PillCam ESO endoscopy. In one patient PillCam ESO detected small varices that were not seen at EGD. The overall concordance between PillCam ESO and EGD was 96.9 % for the diagnosis of esophageal varices and 90.6% for the diagnosis of portal hypertensive gastropathy. There were no adverse events related to PillCam ESO endoscopy. Conclusions: In a high-prevalence population, PillCam ESO may represent an accurate noninvasive alternative to EGD for the detection of esophageal varices and portal hypertensive gastropathy. A large-scale trial is underway to validate and expand these findings. | Eisen G.M. Eliakim R. Zaman A. 纪泛扑 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，5： | 2 |
| 8 | Do genes influence exposure to trauma: A twin study of combat显示文摘 | Lyons M J Geldberg J Eisen S A | 1993 | Am J Med Genet (Neuropsychiatric Genetic)1993，48，1： | 2 |
| 9 | A multicenter, prospective, randomized comparison of a novel signal transmission capsule endoscope to an existing capsule endoscope显示文摘 | Eric H. Choi Klaus Mergener Carol Semrad Laurel Fisher David R. Cave Milan Dodig Carol Burke Jonathan A. Leighton David Kastenberg Peter Simpson James Sul Kanishka Bhattacharya Roger Charles Lauren Gerson Luke Weber Glenn Eisen Warren Reidel John J. Vargo | 2013 | Gastrointestinal Endoscopy2013，，2： | 2 |
| 10 | 显示文摘 | Shor A Eisen Y Mardor I | 1999 | J Nucl Inst and Meth in Phys Res A1999，428，1： | 2 |
| 11 | Procalcitonin as a diagnostic marker for sepsis显示文摘 | Michael Osthoff Damon P Eisen | 2013 | The Lancet Infectious Diseases2013，，12： | 2 |
| 12 | Electromyography in disorders of muscle tone显示文摘 | Eisen A | 1987 | Can J Neural Sci1987，14，： | 2 |
| 13 | EUS vs MRCP for detection of choledocholithiasis显示文摘 | Dharmendra Verma Asha Kapadia Glenn M. Eisen Douglas G. Adler | 2006 | Gastrointestinal Endoscopy2006，，2： | 2 |
| 14 | A Pooled Analysis to Evaluate Results of Capsule Endoscopy Trials显示文摘 | B. Lewis G. Eisen S. Friedman | 2005 | Endoscopy2005，，10： | 2 |
| 15 | A lexicon for endoscopic adverse events: report of an ASGE workshop显示文摘 | Peter B. Cotton Glenn M. Eisen Lars Aabakken Todd H. Baron Matt M. Hutter Brian C. Jacobson Klaus Mergener Albert Nemcek Bret T. Petersen John L. Petrini Irving M. Pike Linda Rabeneck Joseph Romagnuolo John J. Vargo | 2010 | Gastrointestinal Endoscopy2010，，3： | 2 |
| 16 | Safety, tolerability, and efficacy of cyclosporine microemulsion in heart transplant recipients显示文摘 | Eisen HJ Hobbs RE Davis SF | 2001 | Transplantation2001，71，1： | 1 |
| 17 | Guideline for the management of ingested foreign bodies显示文摘 | Eisen GM Baron TH Dominitz JA | 2002 | Gastrointest Endosc2002，35，： | 1 |
| 18 | The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients 显示文摘 | Eisen D | 2002 | J Am Aead Dermatol2002，46，2： | 1 |
| 19 | Scrafenib in advanced melanoma:a phase II randomised discontinuation trial analysis显示文摘 | Eisen T Ahrnad T Flaherty K T el al | 2006 | Br J Cancer2006，95，5： | 1 |
| 20 | Distinct types of dif-fuse large B-cell lymphoma identified by gene expression profiling显示文摘 | Alizadeh AA Eisen MB Davis RE | 2000 | Nature2000，403，： | 1 |
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