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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 3 | A simplified risk score for predicting postoperative nausea and vomiting 显示文摘 | APFEL CC LAARA E KOIVURANTA M | 1999 | Anaesthesiology1999，91，3： | 1 |
| 4 | Lung cancer in never smokers: molecular profiles and therapeutic implications 显示文摘 | Rudin CM Avila-Tang E Harris CC | 2009 | Clin Cancer Res2009，15，18： | 1 |
| 5 | Immunocytochemistry:Its evolution and criteria for its application in the study of epon-embedded cells and tissues显示文摘 | Gosselin E J Cate CC Pettengill OS | 1986 | Am J Anat1986，175，： | 1 |
| 6 | Successful treatment of infantile hemangiomas with interferon-alpha-2b显示文摘 | Chang E Boyd A Nelson CC | 1997 | J Pediatr Hematol Oncol1997，19，3： | 1 |
| 7 | Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection显示文摘 | Ozkaynak E Shemmeri WN Wang CC | 2001 | Nat Immunol2001，2，7： | 1 |
| 8 | Tennlnal B-cell matura- tion and immunoglobulin synthesis in vitro in patients with major in jury显示文摘 | FAIST E ERTEL W BAKER CC | 1989 | Trauma1989，，29： | 1 |
| 9 | Prognostic interaction between thrombocytosis and JAK2V617F mutation in the WHO subcateories of melodysplastic/myeloproliferative disease-unclassifiable and refractory anemia with ringed sideroblasts and marked thrombocytosis Leukemia显示文摘 | Atallah E Nussenzveig R Yin CC | 2008 | 22 (6):1295-12982008，22，6： | 1 |
| 10 | Successful treatment of infantile hemangiomas with interferon-alpha-2b显示文摘 | Chang E Boyd A Nelson CC | | 0，，： | 1 |
| 11 | Early atheroma in primary and secondary antiphospholipid syndrome : an intrinsic finding显示文摘 | Belizna CC Richard V Primard E | 2008 | Semin Arthritis Rheum2008，37，6： | 1 |
| 12 | Effective treatment of mycoplasma contamination in cell lines with enrofloxacin ( Baytril )显示文摘 | Fleckenstein E Uphoff CC | 1994 | Leukemia1994，8，： | 1 |
| 13 | Persistent inhibition of cell respiration by nitric oxide : crucial role of S- nitrosylation of ruitochondrial complex Ⅰ and protective aetion of glutathione 显示文摘 | Clementi E Brown CC Feelisch M | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 14 | A simplified risk score for predicting postoperative nausea and vomiting: conelusiong from cross-validations between two centers显示文摘 | Apfel CC Laara E Koivuranta M | 1999 | Anesthesiology1999，91，： | 1 |
| 15 | A simplified risk score for predicting postoperative nausea and vomiting显示文摘 | Apfel CC Laara E Koivuranta M | 1999 | Anesthesiology1999，91，： | 1 |
| 16 | Repression of HPV16 early region transcription by the E2 protein 显示文摘 | Soeda E Ferran MC Baker CC | 2006 | Virol2006，351，： | 1 |
| 17 | Comparative sensitivity of HBV NATs and HBsAg assays for detection of acute HBV infee- tion显示文摘 | Biswas R Tabor E Hsia CC | 2003 | Transfusion2003，43，6： | 1 |
| 18 | Netting neu- trophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus显示文摘 | Villanueva E Yalavarthi S Berthier CC | 2011 | J Immunol2011，187，1： | 1 |
| 19 | Clinical and immunohistologic studies of rejection in the rat penetrating keratoplasty model 显示文摘 | Holland E J Chan CC Wetzig RP | 1991 | Cornea1991，10，5： | 1 |
| 20 | Clinical aspects and molecular di- agnostics of skin aging显示文摘 | Zouboulis CC Makrantonaki E | 2011 | Clin Dermatol2011，29，1： | 1 |
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