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| 1 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013,23,7: | 19 |
| 2 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020,9,2: | 15 |
| 3 | Xp11易位性肾细胞癌和免疫组化TFE3强阳性的透明细胞性肾细胞癌:形态学、免疫组化和FISH分析显示文摘TFE3是诊断Xp11易位性肾细胞癌的良好标志物。然而,TFE3在其他类型肾细胞癌中的意义尚不清楚。作者利用自动化Ventana BenchMark XT系统采用免疫组化法检测了1 818例肾细胞癌组织中TFE3的表达情况,并用TFE3分裂探针采用荧光原位杂交和RNA测序技术检测了TFE3强阳性病例。27例免疫组化TFE3强阳性的肾细胞癌中,20例诊断为Xp11易位性肾细胞癌,7例诊断为透明细胞性肾细胞癌。作者进一步分析了形态学和临床病理特征,以及免疫组化标志物(CK7、CD117、CD10、P504s、vimentin、CA-IX、CK(AE1/AE3)、EMA、HMB-45、Melan-A和组织蛋白酶K)的表达情况。暗淡至嗜酸性絮状胞质及砂粒体样钙化仅见于Xp11易位性肾细胞癌( P <0.05)。4例pT3a期Xp11易位肾性细胞癌均发生肿瘤性坏死,3年内出现局部复发和远处转移(其中2例死亡)。vimentin、CA-IX、CK(AE1/AE3)和EMA在这两种肾细胞癌中的表达差异有显著性( P <0.05)。 | 魏建国(摘译) 方三高(审校) Yang B Duan H Cao W | 2019 | 临床与实验病理学杂志2019,35,8: | 11 |
| 4 | Magnetic response to atmospheric heavy metal pollution recorded by dust-loaded leaves in Shougang industrial area, western Beijing显示文摘Fifty-five evergreen tree's leaves growing less than one year were collected from Shougang industrial area in western suburb of Beijing, including steel plants and its ambient residential areas, recreational parks and farmlands. Rock magnetic properties and heavy metal contents were studied. The results show that the magnetic properties of leaf samples are predominated by low-coercivity magnetite, and both the concentration and grain size of magnetite particles gradually decreased with the distance from the main pollution source increases. Moreover, there is a significant linear relationship between magnetic parameters (the low-field magnetic susceptibility, saturation isothermal remanent magnetization and anhysteretic remanent magnetization) and heavy metals contents (Fe, Pb, V, Cr and Zn) (0.73≤R≤ 0.88). Hence, the magnetic parameters of leaves can serve as a proxy for quick detecting of the recent atmospheric metallic pollution. | HU ShouYun DUAN XueMei SHEN MingJie U BLAHA W ROESLER YAN HaiTao E APPEL V HOFFMANN | 2008 | Chinese Science Bulletin2008,53,10: | 10 |
| 5 | A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation显示文摘Transposons 被 epigenetic 机制通常包括 DNA methylation 使沉默。这里,我们识别了一双先驱导出 transposon 的蛋白质(HDP ) , HDP1 和 HDP2,在 Arabidopsis 的反沉默因素。hdp1 和 hdp2 异种显示了 transgenes 和某 transposons 的提高的 silencing。种系发生的分析表明 HDP1 和 HDP2 分别地从先驱编码 transposon 的 transposase 和 DNA 有约束力的蛋白质被共同驯养。HDP1 在原子核与 HDP2 交往,类似于他们的 transposon 对应物。而且, HDP1 和 HDP2 与组成在 DNA demethylation 工作的 histone acetyltransferase 建筑群的 IDM1, IDM2, IDM3 和 MBD7 被联系。HDP2 和 methyl-DNA-binding 蛋白质 MBD7 分享普通 genomic 绑定地点的一个大集合,显示他们联合决定 histone acetyltransferase 建筑群的目标特性。因此,我们的数据表明 HDP1 和 HDP2 组成被招募了到 histone acetyltransferase 建筑群阻止 DNA hypermethylation 和 epigenetic silencing 的一个功能的模块。 | Cheng-Guo Duan Xingang Wang Shaojun Xie Li Pan Daisuke Miki Kai Tang Chuan-Chih Hsu Mingguang Lei Yingli Zhong Yueh-Ju Hou ZhijuanWang Zhengjing Zhang Satendra K Mangrauthia Huawei Xu Heng Zhang Brian Dilkes W Andy Tao Jian-Kang Zhu | 2017 | Cell Research2017,27,2: | 6 |
| 6 | Neurodegenerative disorders and ischemic brain diseases显示文摘 | Attson MP Duan W Pedersen WA | 2001 | Apoptosis2001,,: | 2 |
| 7 | 查看详情显示文摘 | W S Duan K P Lu J B Zhao | | 0,,: | 2 |
| 8 | A generalized diffraction synthesis technique for high performance reflector antennas显示文摘 | Duan D W | 1995 | IEEE Trans AP1995,43,: | 2 |
| 9 | Weighted rational cubic spline interpolation and its application显示文摘 | Duan Qi Djidjeli K Price W G | 2000 | Journal of Computational and Applied Mathematics2000,117,: | 1 |
| 10 | Formation and properties of new Ni-based amorphous alloys with critical casting thickness up to 5 mm显示文摘 | XU D H DUAN G JOHNSON W L | 2004 | Acta Materialia2004,52,: | 1 |
| 11 | Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats 显示文摘 | Zhao L R Duan W M Reyes M | 2002 | Exp Neurol2002,174,1: | 1 |
| 12 | ATP-induced changes in energy status and membrane integrity of harvested litchi fruit and its relation to pathogen resistance 显示文摘 | YI C QU H X JIANG Y M SHI J DUAN X W JOYCE D C LI Y B | 2008 | Journal of Phytopathology2008,156,: | 1 |
| 13 | Numerical simulation of oblique water entry of an asymmetrical wedge显示文摘 | Xu G D Duan W Y Wu G X | 2008 | Ocean Engineering2008,35,16: | 1 |
| 14 | Ontogenesis of transthyretin gene expression in chicken choroids plexus and liver显示文摘 | Southwell B R Duan W Tu G F | 1991 | Comp Biochem Physiol1991,100,: | 1 |
| 15 | Genome-wide identification of quantitative trait loci for pork temperature, pH decline, and glycolytic potential in a large-scale White Duroc x Chinese Erhualian resource population显示文摘 | Duan YY Ma J W Yuan F | 2008 | J Anita Sei2008,87,1: | 1 |
| 16 | The myocardial protec-tive effects of adenosine pretreatment in children undergoing car-diac surgery : a randomized controlled clinical trial 显示文摘 | Jin Z Duan W Chen M Yu St | 2011 | Eur JCardiothorac Surg2011,39,5: | 1 |
| 17 | Investigation on coal pyrolysis in CO2 atmosphere显示文摘 | DUAN L B ZHAO C S ZHOU W QU C R CHEN X P | 2009 | Energy Fuels2009,23,7: | 1 |
| 18 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008,,4: | 1 |
| 19 | Electronic structure of carbon nanotube in the growth显示文摘 | ZHOU G DUAN W H GU B L | 2001 | Chem J Chinese U2001,22,11: | 1 |
| 20 | Core-shell struc- ture design of pulverized expandable graphite particles and their application in flame-retardant rigid polyurethane foams显示文摘 | Duan H J Kang H Q Zhang W Q | 2014 | Polym Int2014,63,1: | 1 |