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| 1 | Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro显示文摘 | Lian G Wang C Teng C Zhang C Du L Zhong Q Miao C Ding M Deng H | 2006 | 中国生物学文摘2006，20，5： | 11 |
| 2 | Standardizing a simpler, more sensitive and accurate tail bleeding assay in mice显示文摘AIM: To optimize the experimental protocols for a simple, sensitive and accurate bleeding assay.METHODS: Bleeding assay was performed in mice by tail tip amputation, immersing the tail in saline at 37 ℃, continuously monitoring bleeding patterns and measuring bleeding volume from changes in the body weight. Sensitivity and extent of variation of bleeding time and bleeding volume were compared in mice treated with the P2 Y receptor inhibitor prasugrel at various doses or in mice deficient of Fc Rγ, a signaling protein of the glycoprotein VI receptor.RESULTS: We described details of the bleeding assay with the aim of standardizing this commonly used assay. The bleeding assay detailed here was simple to operate and permitted continuous monitoring of bleedingpattern and detection of re-bleeding. We also reported a simple and accurate way of quantifying bleeding volume from changes in the body weight, which correlated well with chemical assay of hemoglobin levels(r2 = 0.990, P < 0.0001). We determined by tail bleeding assay the dose-effect relation of the anti-platelet drug prasugrel from 0.015 to 5 mg/kg. Our results showed that the correlation of bleeding time and volume was unsatisfactory and that compared with the bleeding time, bleeding volume was more sensitive in detecting a partial inhibition of platelet's haemostatic activity(P < 0.01). Similarly, in mice with genetic disruption of Fc Rγ as a signaling molecule of P-selectin glycoprotein ligand-1 leading to platelet dysfunction, both increased bleeding volume and repeated bleeding pattern defined the phenotype of the knockout mice better than that of a prolonged bleeding time.CONCLUSION: Determination of bleeding pattern and bleeding volume, in addition to bleeding time, improved the sensitivity and accuracy of this assay, particularly when platelet function is partially inhibited. | Yang Liu Nicole L Jennings Anthony M Dart Xiao-Jun Du | 2012 | World Journal of Experimental Medicine2012，2，2： | 6 |
| 3 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 4 | 母乳喂养和孕产妇心血管病风险:30万中国妇女的前瞻性研究显示文摘母乳喂养给儿童健康带来了大量好处,并且也与母亲生命后期心血管病风险降低相关。然而,有关其对心血管病影响的证据仍然不一致,特别是在东亚人中,母乳喂养的频率和持续时间与西方国家的频率和持续时间显著不同。2004-2008年,中国香港嘉道理生物样本库(China Kadoorie biobank)从中国10个不同地区招募了年龄30-79岁受试者50万人,基线无心血管病的女性受试者289 573人在8年的随访中, | 刘莉 叶鹏 Peters SAE Yang L Guo Y Chen Y Bian Z Du J Yang J Li S Li L Woodward M Chen Z | 2017 | 中华高血压杂志2017，25，8： | 4 |
| 5 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 6 | Preparation,characterization and antimicrobial activity of quaternized carboxymethyl chitosan and application as pulp-cap显示文摘 | SUN L P DU Y M FAN L H | 2006 | Polymer2006，47，6： | 1 |
| 7 | Electro-optically Q-switched Ndz YVO4 slab laser with a high repetition rate and a short pulse width显示文摘 | DU K M LI D J ZHANG H L etal | 2003 | Optics Letters2003，28，2： | 1 |
| 8 | Differential myocardial gene delivery by recombinant serotype-specific adeno-associated viral vectors显示文摘 | Du L Kido M Lee DV | 2004 | Mol Ther2004，10，： | 1 |
| 9 | Quantitative evaluation of precipitates in an A1-Zn-Mg-Cu alloy after isothermal aging 显示文摘 | DU Z W SUN Z M SHAO B L ZHOU T T CHEN C Q | 2006 | Materials Characterization2006，56，： | 1 |
| 10 | Facile preparation of monodisperse micrometer-sized hollow silica spheres with tunable size and commendable surface topography 显示文摘 | Xu M Z Du M X Zhao L M | 2010 | Materials Research Bulletin2010，45，9： | 1 |
| 11 | Stem cell therapy restores transparency to defective murine corneas显示文摘 | Du Y Carlson E C Funderburgh M L | | 0，，07： | 1 |
| 12 | Numerical simulation of an advanced energy storage system using H2O-LiBr as working fluid(Ⅱ):System simulation and analysis显示文摘 | Xu S M Xu C H Zhang L Liang J Du R | | 0，，02： | 1 |
| 13 | Defect detection in periodically patterned sur- faces using independent component analysis 显示文摘 | DU M T SHIA C L | 2008 | Pattern Reeogni- tion2008，41，9： | 1 |
| 14 | Hypoxia - inducible factor 1 - Alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse显示文摘 | Kido M Du L Sullivan CC | 2005 | J Am Coll Cardiol2005，46，11： | 1 |
| 15 | Attitudes of ranchers to- wards African wild dogs Lycaon pictus: Conservation implications on private land 显示文摘 | Lindsey P A du Toit J T Mills M G L | 2005 | Biological Conservation2005，125，1： | 1 |
| 16 | A lightning locationsystem in China:its performances and applications显示文摘 | CHEN S M DU Y FAN L M | 2002 | IEEEtransactions on electromagnetic compatibility2002，44，4： | 1 |
| 17 | Chemical fingerprinting of unevaporated automotive gasoline samples 显示文摘 | SANDERCOCK P M L PASQUIER E Du | 2004 | Forensic Science International2004，140，： | 1 |
| 18 | Host plants and natural enemies of Bemisia tabaci (Homoptera:Aleyrodidae) in China显示文摘 | LiS J Xue X Ahmed M Z Ren S X Du Y Z Wu J H Cuthbertson A G S and Qiu B L | | 0，，： | 1 |
| 19 | Atorvastatin inhibits hyperglycemiainduced expression of osteopontin in the diabetic rat kidney via the p38 MAPK pathway显示文摘 | Zuo L Du Y Lu M | 2014 | Mol Biol Rep2014，41，4： | 1 |
| 20 | A chlorophyllreduced mutant in oilseed rape, Brassica napus, or utilization in F1 hybrid production 显示文摘 | Zhao Y Wang M L Zhang Y Z Du LF Pan T | 2000 | Plant Breed2000，119，： | 1 |
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