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| 1 | New fecal test for non-invasive Helicobacter pylori detection:A diagnostic accuracy study显示文摘AIM To assess the diagnostic accuracy of a new fecal test for detecting Helicobacter pylori(H. pylori), using ^(13)Curea breath test as the reference standard, and explore bacterial antibiotic resistance. METHODS We conducted a prospective two-center diagnostic test accuracy study. We enrolled consecutive people≥ 18 years without previous diagnosis of H. pylori infection, referred for dyspepsia between February and October 2017. At enrollment, all participants underwent 13 C-urea breath test. Participants aged over 50 years were scheduled to undergo upper endoscopy with histology. Participants collected stool samples 1-3 d after enrollment for a new fecal investigation(THD fecal test). The detection of bacterial 23 S rRNA subunit gene indicated H. pylori infection. We also used the index diagnostic test to examine mutations conferring resistance to clarithromycin and levofloxacin. Independent investigators analyzed index test and reference test standard results blinded to the other test findings. We estimated sensitivity, specificity, positive(PPV) and negative(NPV) predictive value, diagnostic accuracy, positive and negative likelihood ratio(LR), together with 95% confidence intervals(CI).RESULTS We enrolled 294 consecutive participants(age: Median 37.0 years, IQR: 29.0-46.0 years; men: 39.8%). Ninetyfive(32.3%) participants had a positive ^(13)C-urea breath test. Twenty-three(7.8%) participants underwent upper endoscopy with histology, with a full concordance between ^(13)C-urea breath test and histology in detecting H. pylori infection. Four(1.4%) out of the 294 participants withdrew from the study after the enrollment visit and did not undergo THD fecal testing. In the 290 participants who completed the study, the THD fecal test sensitivity was 90.2%(CI: 84.2%-96.3%), specificity 98.5%(CI:96.8%-100%), PPV 96.5%(CI: 92.6%-100%), NPV 95.6%(CI: 92.8%-98.4%), accuracy 95.9%(CI: 93.6%-98.2%), positive LR 59.5(CI: 19.3-183.4), negative LR 0.10(CI: 0.05-0.18). Out of 83 infected participants identified with the THD fecal test, 34(41.0%) had bacterial genotypic changes consistent with antibiotic-resistant H. pylori infection. Of these, 27(32.5%) had bacterial strains resistant to clarithromycin, 3(3.6%) to levofloxacin, and 4(4.8%) to both antibiotics. CONCLUSION The THD fecal test has high performance for the non-invasive diagnosis of H. pylori infection while additionally enabling the assessment of bacterial antibiotic resistances. | Andrea Iannone Floriana Giorgio Francesco Russo Giuseppe Riezzo Bruna Girardi Maria Pricci Suetonia C Palmer Michele Barone Mariabeatrice Principi Giovanni FM Strippoli Alfredo Di Leo Enzo Ierardi | 2018 | World Journal of Gastroenterology2018，24，27： | 5 |
| 2 | Role of Ultrasound in Mass-Casualty Situations显示文摘 | Abu-Zidan FM | 2004 | lntemational Journal of Disaster Medicine2004，2，： | 1 |
| 3 | De- creased complex activity in mitochondria isolated from rat heart subjected to ischemia and reperfusion :role of reac- tive oxygen species and cardiopin 显示文摘 | Petrosillo G Ruggiero FM Di Venosa N | 2003 | FASEB J2003，17，6： | 1 |
| 4 | Early virologic response after peginterferon alpha-2a plus ribavirin or peginterferon alpha-2b plus ribavirin treatment in patients with chronic hepatitis C显示文摘 | Di Bisceglie AM Ghalib RH Hamzeh FM | 2011 | Viral Hepat2011，14，6： | 1 |
| 5 | Blue-dye sentinel node mapping in thyroid carcinoma:debatable results of feasibility显示文摘 | Peparini N Maturo A Di Matteo FM | | 0，，05： | 1 |
| 6 | CEUS in the dif- ferentiation between low and high-grade bladder carcino ma显示文摘 | Drudi FM Di Leo N Malpassini F | 2012 | Ultrasound2012，15，24： | 1 |
| 7 | Uterine fibroids affect pregnancy out- come in women over 30 years old : role of other risk factors 显示文摘 | Conti N Tosti C Pinzauti S Tomaiuolo T Cevenini G Severi FM Di Tommaso M Petraglia F | 2013 | Matem Fetal Neonatal Med2013，26，6： | 1 |
| 8 | Novel strategies: challenge loop diuretics and sodium management in heart failure-part I 显示文摘 | Di Pasquale P Sarullo FM Paterna S | 2007 | Congest Heart Fail2007，13，2： | 1 |
| 9 | Efficacy of rescue thrombolysis in patients with acute myocardial infarction: preliminary findings显示文摘 | Sarullo FM Americo L Di Pasquale P | 2000 | Cardiovas Drugs Ther2000，14，1： | 1 |
| 10 | Proteomic and transcriptumic study on the action of a cytotoxic saponin (Polyphyllin D) :induction of endoplas- mic reticulum stress and mitochondria-mediated apoptotic pathways 显示文摘 | Siu FM Ma DI Cheung YW | 2008 | Proteomics2008，8，15： | 1 |
| 11 | Effects of administration of glycoprotein Ⅱb/Ⅲa receptor antagonists in patients with failed thrombolysis: Apilot study显示文摘 | Di Pasquale P Sarullo FM Cannizzaro S | 2001 | Clin Drug Invest2001，21，8： | 1 |
| 12 | COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement显示文摘 | Diomedi-Camassei F Di Giandomenico S Santorelli FM | 2007 | J Am Soc Nephrol2007，18，10： | 1 |
| 13 | The athlete heart : remode- ling, electrocardiogram and preparticipation screening显示文摘 | A Pelliccia FM Di Paolo BJ Maron | 2002 | Cardi- ol Rev March 12002，10，2： | 1 |
| 14 | Portrait of inflammatory response to ionizing radiation treatment 显示文摘 | Di Maggio FM Minafra L Forte GI | 2015 | J Inflamm (Lond)2015，12，1： | 1 |
| 15 | Micromedullary thyroid carcinoma: school experience 显示文摘 | Palermo S Di Matteo FM Savino G | 2010 | G Chir2010，31，67： | 1 |
| 16 | Prevalence and clinical signifi- cance of left atrial remodeling in competitive athletes 显示文摘 | Pelliccia A Maron BJ di Paolo FM | 2005 | J Am Coil Cardiol2005，46，： | 1 |
| 17 | Beta-blockers and ivahradine in chronic heart failure : from clinical trials to clinical practice 显示文摘 | Di Franeo A Sarullo FM Salerno Y | 2014 | Am J Cardiovasc Drugs2014，14，2： | 1 |
| 18 | Role of tumor necrosis factor a release and leukocyte margination in indomethacin-induced gastric injury in rats显示文摘 | Santucci L Fiorucci S Di Matteo FM | 1995 | Gastroenterology1995，108，2： | 1 |
| 19 | Molecular characterization of Noroviruses and rotaviruses involved in a large outbreak of gastroenteritis in Northern Italy 显示文摘 | Di Bartolo I Monini M Losio MN Pavoni E Lavazza A Ruggeri FM | 2011 | Appl Environ Microbiol2011，77，15： | 1 |
| 20 | Blue-dye sentinel nodemapping in thyroid carcinoma: debatable results of feasibility 显示文摘 | Peparini N Maturo A Di Matteo FM | 2006 | Acta Chit Belg2006，106，5： | 1 |
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