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| 1 | PBL:教育实践和研究的未来挑战显示文摘本文是一篇有关PBL的评论性研究,根据现代学习理论,作者论述了四个有关学习的原则,解释了这些原则在PBL中的应用,并对已进行的研究进行了评议。 | Diana HJM Dolmans Willem De Grave Ineke HAP Wolfhagen Cees PM van der Vleuten 梅人朗 | 2008 | 复旦教育论坛2008，6，1： | 44 |
| 2 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 3 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet . 2009 (9688)2009，，9688： | 4 |
| 4 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 5 | Consensus on the definition of colorectal anastomotic leakage: A modified Delphi study显示文摘BACKGROUND Despite the emerging knowledge about colorectal anastomotic leakage(CAL)through the increasing number of clinical and experimental studies, there is no generally accepted definition of CAL. Because of the wide variety of definitions used in literature, comparison of study outcomes and quality of care is complicated.AIM To reach consensus on the definition of CAL using a modified Delphi method.METHODS The RAND/UCLA appropriateness method was used. The expert panel consisted of international colorectal surgeons and researchers who had published three or more articles about CAL. The consensus process consisted of two online distributed questionnaires and a third round with a recommendation. In the questionnaires participants were asked to rate the appropriateness of statements using a 1-9 Likert scale. Consensus was defined as a panel median between 1-3 or 7-9 without disagreement. In the final round a recommendation was formed regarding the definition of CAL and the expert panel was asked if they agreed or disagreed.RESULTSTwenty-three authors participated in the first round and twenty-one finished the second round. After two rounds consensus was reached on 37 items(80%) in nine different categories. The International Study Group of Rectal Cancer definition is the most frequently advised general definition by our panel. Consensus was reached regarding the clinical symptoms of CAL, which serum markers contributes to the suspicion of CAL, which radiological and perioperative findings should be considered as CAL, which grading system is appropriate and if there should be a range of postoperative days in the definition. Eventually, 19 experts completed all three rounds of which 16(84%) agreed with our final recommendations for the definition of CAL.CONCLUSION A consensus-based recommendation for the definition of CAL was formed using our modified Delphi method that can be widely incorporated in the field. | Claire PM van Helsdingen Audrey CHM Jongen Wouter J de Jonge Nicole D Bouvy Joep PM Derikx | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 6 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet2009，，9688： | 2 |
| 7 | β-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas:role in the regulation of response to somatostatin analogue treatment in patients with acromegaly显示文摘Recent in vitro studies highlighted G protein-coupled receptor kinase(GRK)2 andβ-arrestins as important players in driving somatostatin receptor(SSTR)desensitization and trafficking.Our aim was to characterize GRK2 andβ-arrestins expression in different pituitary adenomas and to investigate their potential role in the response to somatostatin analog(SSA)treatment in GHsecreting adenomas(GHomas).We evaluated mRNA expression of multiple SSTRs,GRK2,β-arrestin 1,andβ-arrestin 2 in 41pituitary adenomas(31 GHomas,6 nonfunctioning[NFPAs],and 4 prolactinomas[PRLomas]).Within the GHomas group,mRNA data were correlated with the in vivo response to an acute octreotide test and with the GH-lowering effect of SSA in cultured primary cells.β-Arrestin 1 expression was low in all 3 adenoma histotypes.However,its expression was significantly lower in GHomas | Gatto F Feelders R van der Pas R Kros JM Dogan F van Koetsveld PM van der Lelij AJ Neggers SJ Minuto F de Herder W Lamberts SW Ferone D Hofland LJ | 2013 | 中国神经肿瘤杂志2013，11，4： | 2 |
| 8 | The Risk of Recurreny Deep Venous Thrombosis Among Heterozygous Carriers of Both Factor V Leiden and the G20210A Prothrombin mutation显示文摘 | Martinelli I Mannuccio PM | 1999 | N Engl J Med1999，341，： | 1 |
| 9 | Testicular growth,sperm concentration,percent motility,and pregnancy outcome after varicocelectomy based on testicular histology显示文摘 | Pasqualotto FF Lucon AM de Goes PM | 2005 | Fertil Steril2005，83，2： | 1 |
| 10 | Anesthesia in pa-tients with chronic obstructive pulmonary diseases显示文摘 | Spieth PM Güldner A Gama de Abreu M | 2010 | Anaesthesist2010，59，1： | 1 |
| 11 | Development of a selective culture medium for primary isolation of the main Brucella species 显示文摘 | De Miguel MJ Marin CM Munoz PM | 2011 | J Clin Microbio12011，49，： | 1 |
| 12 | Flexion and rota- tion of the trunk and lifting at work are risk factors for low back pain resuhs of a prospective cohort study 显示文摘 | Hoogendoorn WE Bongers PM de Vet HC | 2000 | Spine2000，25，23： | 1 |
| 13 | Knee flexion deformity from poliomyelitis treated by supracondylar femoral extension osteotomy显示文摘 | De Moraes PM Svartman C De Assumpao RM | 2005 | Int Orthop2005，29，： | 1 |
| 14 | Established and emerging plasma biomarkers in the prediction of first atherothrombotic events 显示文摘 | Ridker PM Brown NJ Vaughan DE | 2004 | Circulation2004，109，1： | 1 |
| 15 | Thymeetomy by povrtial sternotomy for treatment of myasthenia gravis 显示文摘 | Pego-Fermandes PM de Campos JR Jatene FB | 2002 | Ann Thorac Surg2002，74，： | 1 |
| 16 | HDL modification by secretory phospholipase A(2) promotes scavenger receptor class B type I interaction and accelerates HDL catabolism 显示文摘 | de Beer PC Connell PM Yu J | 2000 | J Lipid Res2000，41，11： | 1 |
| 17 | Established and emerging plasma biomarkers in the prediction of first atherothrombotic events显示文摘 | Ridker PM Brown NJ Vaughan DE | 2004 | Circulation2004，109，251： | 1 |
| 18 | Novel function of complement C3d as an autologous helper T-cell target显示文摘 | Knopf PM Rivera DS Hai SH McMurry J Martin W De Groot AS | | 0，，03： | 1 |
| 19 | Displaced humeral lateral condyle fractures in children:should we bury the pins? 显示文摘 | Das De S Bae DS Waters PM | 2012 | J Pediatr Orthop2012，32，6： | 1 |
| 20 | Percutaneous laser photocoagulation of osteoid osteoma under CT guidance显示文摘 | Smith SP Hughes PM | 2003 | Clin Radiol2003，58，3： | 1 |
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