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| 1 | 代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点(英文)显示文摘Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous system.However,evidences have suggested other roles of mG luR in human tumors.Aberrant mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain tumors.This review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG luR ligands.In addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K pathways.In addition,mG luR3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κB.Further,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft models.In parallel,low levels of mG luR3 mRNA in GBM resections may be a predictor for long survival rate of patients.Since several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors. | Pereira MS Klamt F Thomé CC Worm PV de Oliveira DL | 2017 | 中华神经外科疾病研究杂志2017，16，1： | 3 |
| 2 | Antioxidant and free radical scavenging effects of baicalein,baicalin and wogonin显示文摘 | Shieh DE Liu LT Lin CC | 2000 | Anticancer Res2000，20，5： | 1 |
| 3 | Growth of preterm born children显示文摘 | Euser AM de Wit CC Finken M J | | 0，，： | 1 |
| 4 | Surgical treatment of type 2 diabetes in patients with BMI below 35:mid-term outcomes of the laparoscopic ileal interposition associated with a sleeve gastrectomy in 202 consecutive cases显示文摘 | De Paula AL Stival AR De Paula CC | 2012 | J Gastrointest Surg2012，16，5： | 1 |
| 5 | Regulation of ocular inflammation-what experimental and human stmties have taught us 显示文摘 | de Smet MD Chan CC | 2001 | Progr Retin Eye Res2001，20，6： | 1 |
| 6 | Peritumoral brain edema in benign meningiomas: correlation with clinical, radiologic, and surgical factors and possible role on recurrence 显示文摘 | Simis A Pires de Agniar PH Leite CC | 2008 | Surg Neurol2008，70，5： | 1 |
| 7 | Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis显示文摘 | De Souza Setubal Desteo MF Bitu CC Zecchin KG | 2010 | Int J Oncol2010，36，1： | 1 |
| 8 | Infrared-triggered cameras for detecting wildlife: an evaluation and review 显示文摘 | Swann DE Hass CC Dalton DC | 2004 | Wildlife Soc Bull2004，32，2： | 1 |
| 9 | Endocrine and clinical effects of micronized estradiol administered vaginally or orally显示文摘 | Tourgeman DE Slater CC Stanczyk FZ | 2001 | Fertil Steril2001，75，： | 1 |
| 10 | Microplate enzyme-linked immunosorbent assay for Chagas disease显示文摘 | Voller A Draper CC Bidwell DE | 1975 | Lancet1975，1，： | 1 |
| 11 | Comparison of the haemo- dynamic effects of right ventricular outflow-tract pacing with right ventricular apex pacing:a quantitative review显示文摘 | De Cock CC Giudici MC Twisk JW | 2003 | Europace2003，5，3： | 1 |
| 12 | Cxcl8 (IL-8)mediates neutrophil recruitment and behavior in the zebrafishinflammatory response 显示文摘 | de Oliveira S Reyes-Aldasoro CC Candel S | 2013 | J Immunol2013，190，8： | 1 |
| 13 | Effects of stimulation site on diastolic function in cardiac resynchronization therapy 显示文摘 | de Cock CC Vos OH Jessurun E | 2007 | PACE2007，30，1： | 1 |
| 14 | Results of surgical treatment of T4 non - small cell lung cancer 显示文摘 | Pitz CC Brutel de la Riviere A van Swieten HA | 2003 | Eur J Cardiothorac Surg2003，24，6： | 1 |
| 15 | Tat peptide as an efficient molecule to translocate gold nanoparticles into the cell nucleus 显示文摘 | de la Fuente JM Berry CC | 2005 | Bioconjug Chem2005，16，： | 1 |
| 16 | Tat peptide as an efficient molecule to translocate gold nanoparticles into the cell nucleus 显示文摘 | De la Fuente JM Berry CC | 2005 | Bioconjug Chem2005，16，5： | 1 |
| 17 | Peritumoral brain edema in benign meningiomas: correlation with clinical, radiologic, and surgical factors and possible role on recurrence显示文摘 | Simis A Pires de Aguiar PH Leite CC | 2008 | Surg Neurol2008，70，： | 1 |
| 18 | Diagnostic and therapeutic challenges of severe Rh e-specific IgA-mediated autoim- mune hemolytic anemia 显示文摘 | Boven LA de Haar-Holleman A Folman CC | 2012 | Annals of Hematology2012，91，4： | 1 |
| 19 | Hemodyrmmic benefits of right ventricular outflow tractpacing: Comparison with right ventricular apex pacing 显示文摘 | De Cock CC Meyer A Kamp O | 1998 | Pace1998，21，3： | 1 |
| 20 | Spinocerebellar ataxias in the Netherlands:prevalence and age at onset variance analysis显示文摘 | van de Warrenburg BP Sinke RJ Verschuuren-Bemelmans CC | 2002 | Neurology2002，58，5： | 1 |
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