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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 3 | Isolation of angiopoietin-1,a ligand for the TIE2 receptor,by secretion-trap expression cloning 显示文摘 | David S Aldrich T H Johes P F | 1996 | Cell1996，87，7： | 2 |
| 4 | Optimal bidding strategies and modelling of imperfect information among competitive generators显示文摘 | Wen F S David A K | 2001 | IEEE Transactions on Power System2001，16，1： | 2 |
| 5 | The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years显示文摘 | Mark R Nelson Christine Katlama Julio S Montaner David A Cooper Brian Gazzard Bonaventura Clotet Adriano Lazzarin Knud Schewe Joep Lange Christina Wyatt Sue Curtis Shan-Shan Chen Stephen Smith Norbert Bischofberger James F Rooney | 2007 | AIDS2007，，10： | 2 |
| 6 | Optimal bidding strategies and modeling of imperfect information among competitive generators显示文摘 | Wen F S David A K | 2001 | IEEE Trans on Power Systems2001，16，1： | 2 |
| 7 | Performance analysis of bearing-only tracking algorithm 显示文摘 | DAVID V HUY S MOHAMMAD F | 2004 | Proceedings of SHE2004，3365，7： | 1 |
| 8 | Market power in electricity supply显示文摘 | David A K Wen F S | 2001 | IEEE Transactions on Energy Conversation2001，16，4： | 1 |
| 9 | Frostfire:An experimental approach to predicting the climate feedbacks from the changing boreal fire regime显示文摘 | Larry D H Masami F David V S | 2003 | Journal of Geophysical Research2003，108，： | 1 |
| 10 | Generation of water-in-oil and oil-in-water microdroplets in polyester-toner microfluidic devices显示文摘 | EVANDRO P DAVIDE F PAOLO S | 2014 | Sensors and Actuators B:Chemical2014，196，6： | 1 |
| 11 | Ramsdellite-MnO2 for lithium batteries: The ramsdellite to spinel transformation显示文摘 | THACKERAY M M ROSSOUW M H GUMMOW R J LILES D C PEARCE K KOCK A D DAVID W I F HULLS S | 1993 | Electrochim Acta1993，38，9： | 1 |
| 12 | Increasing com-pliance with a request : two touches are more effectivethan one 显示文摘 | VAIDI S DAVID C F HALIMI F | 2008 | Psychological Reports2008，，103： | 1 |
| 13 | Optimal Bidding Strategies and Modeling of Imperfect Information Among Competitive Generators显示文摘 | Wen F S David A K | 2001 | IEEE Trans on Power Systems2001，16，1： | 1 |
| 14 | Estimating Intraclass Correlation for Binary Data 显示文摘 | Martin S R Clarice G B and David F | 1999 | Bio- metrics1999，55，1： | 1 |
| 15 | Optimal bidding strategies and modeling of imperfect information among competitive generators显示文摘 | WEN F S DAVID A K | 2001 | IEEE Transactions on Power Systems2001，16，1： | 1 |
| 16 | Optimal bidding strategies and modeling of imperfect information among competitive generators显示文摘 | Wen F S David A K | 2001 | IEEE Transactions on Power Systems2001，16，1： | 1 |
| 17 | Mitochondrial DNA inheritance显示文摘 | DAVID O F SKLBINSKL ZOUROS S E | 1994 | Nature1994，368，6474： | 1 |
| 18 | A simple technique to obtain fused fiber optics couplers 显示文摘 | David S Marco A F Jessica A | 2001 | Journal of Applied Research and Teehnology (S1665-6423)2001，5，3： | 1 |
| 19 | The expression of HSP60 andHSP10 in large bowel carcinomas with lymph node metastase显示文摘 | Cappello F David S Rappa F | 2005 | BMC Cancer2005，5，： | 1 |
| 20 | Mixed reactant photocatalysis:intermediates and mutual rate inhibition 显示文摘 | Craig S Turchi David F Ollis | 1989 | Catal1989，，119： | 1 |
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