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| 1 | Functional optoacoustic neuro-tomography for scalable whole-brain monitoring of calcium indicators显示文摘Non-invasive observation of spatiotemporal activity of large neural populations distributed over entire brains is a longstanding goal of neuroscience.We developed a volumetric multispectral optoacoustic tomography platform for imaging neural activation deep in scattering brains.It can record 100 volumetric frames per second across scalable fields of view ranging between 50 and 1000 mm^(3) with respective spatial resolution of 35–200μm.Experiments performed in immobilized and freely swimming larvae and in adult zebrafish brains expressing the genetically encoded calcium indicator GCaMP5G demonstrate,for the first time,the fundamental ability to directly track neural dynamics using optoacoustics while overcoming the longstanding penetration barrier of optical imaging in scattering brains.The newly developed platform thus offers unprecedented capabilities for functional whole-brain observations of fast calcium dynamics;in combination with optoacoustics'well-established capacity for resolving vascular hemodynamics,it could open new vistas in the study of neural activity and neurovascular coupling in health and disease. | X Luís Deán-Ben Gali Sela Antonella Lauri Moritz Kneipp Vasilis Ntziachristos Gil G Westmeyer Shy Shoham Daniel Razansky | 2016 | Light(Science & Applications)2016，5，1： | 5 |
| 2 | BCL-XL regulates TNF-α-mediated cell death independently of NF-κB, FLIP and IAPs显示文摘 | Raffaella Gozzelino Carme Sole Nuria Llecha Miguel F Segura Rana S Moubarak Victoria Iglesias-Guimarais M Jose Perez-Garcia Stephanie Reix Jisheng Zhang Nahuai Badiola Daniel Sanchis Jose Rodriguez-Alvarez Ramon Trullas Victor J Yuste Joan X Comella | 2008 | Cell Research2008，18，10： | 4 |
| 3 | Stock market volatility, excess returns, and the role of investor sentiment显示文摘 | Wayne Y Lee Christine X Jiang Daniel C Indro | 2002 | Journal of Banking and Finance2002，，12： | 2 |
| 4 | Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells显示文摘AIM:To investigate the impact of arachidonic acid (AA) and docosahexaenoic acid (DHA) and their combination on colon cancer cell growth.METHODS:The LS-174T colon cancer cell line was used to study the role of the prostaglandin precursor AA and the omega-3 polyunsaturated fatty acid DHA on cell growth. Cell viability was assessed in XTT assays. For analysis of cell cycle and cell death,flow cytometry and DAPI staining were applied. Expression of cyclooxygenase-2 (COX-2),p21 and bcl-2 in cells incubated with AA or DHA was examined by real-time RT-PCR. Prostaglandin E2 (PGE2) generation in the presence of AA and DHA was measured using a PGE2-ELISA.RESULTS:AA increased cell growth,whereas DHAreduced viability of LS 174T cells in a time-and dose-dependent manner. Furthermore,DHA down-regulated mRNA of bcl-2 and up-regulated p21. Interestingly,DHA was able to suppress AA-induced cell proliferation and significantly lowered AA-derived PGE2 formation. DHA also down-regulated COX-2 expression. In addition to the effect on PGE2 formation,DHA directly reduced PGE2-induced cell proliferation in a dose-dependent manner. CONCLUSION:These results suggest that DHA can inhibit the pro-proliferative effect of abundant AA or PGE2. | Piet Habbel Karsten H Weylandt Katja Lichopoj Johannes Nowak Martin Purschke Jing-Dong Wang Cheng-Wei He Daniel C Baumgart Jing X Kang | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 5 | Value of postoperative surveillance after radical surgeryfor colorectal cancer: results of a cohort study显示文摘 | Castells A Bessa X Daniels M | 1998 | Dis Colon Reclum1998，41，6： | 1 |
| 6 | New concept in the treatment of Ureteral calculi显示文摘 | Daniel J Painter Francis X | 2001 | Curt Opin urol2001，，11： | 1 |
| 7 | 显示文摘 | Mai Q X Daniels R D Harpalani H B | 1988 | Thin Solid Films1988，166，： | 1 |
| 8 | A methylated oligonueleotide in- hibits IGF2 expression and enhances survival in a model of hepato- cellular carcinoma 显示文摘 | Yao X Hu JF Daniels M | 2003 | J Clin Invest2003，111，2： | 1 |
| 9 | Ionic Liquids in Separations 显示文摘 | Han X X Daniel W | 2007 | Acc Chem Res2007，40，11： | 1 |
| 10 | New concepts in the treatment of ureteral calculi显示文摘 | DANIEL J PAINTER FRCMCIS X | 2001 | Current Opinion Urology2001，，： | 1 |
| 11 | Efficacy of a foot plant-based oral cholera toxin B subunit vaccine显示文摘 | Takeshi Arakawa Daniel Chong K X | 1998 | Nature Biotechnology1998，16，： | 1 |
| 12 | Dynamic economic dispatch: feasible and optimal solutions显示文摘 | Han X S Gooi H B Daniel S K | 2001 | IEEE Trans on Power Apparatus and Systems2001，16，1： | 1 |
| 13 | Molecular mechanisms of biocatalytic desulfurization of fossil fuels显示文摘 | Kevin A G Olga S P Gregry T M Lei X Daniel J M Charles H S | 1996 | Nature Biotechnology1996，14，12： | 1 |
| 14 | Binding of an ETS-related protein within the DNase I hypersensitive site of the HER2/neu promoter in human breast cancer cells 显示文摘 | Scott GK Daniel JC Xiong X | 1994 | J Biol Chem1994，269，19： | 1 |
| 15 | Speciation of hydrocarbon and carbonyl emissions of 2,5-dimethylfu- ran combustion in a DISI engine 显示文摘 | DANIEL R WEI L X XU H M | 2012 | Energy Fuels2012，26，11： | 1 |
| 16 | CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis 显示文摘 | DANIEL X SUGANO S TOBIN E M | 2004 | Proc Natl Acad Sci USA2004，101，9： | 1 |
| 17 | Environmental indicators for business:a review of the literature and standardization methods 显示文摘 | Olsthoorn X Daniel T Walter W Marcus W | 2001 | Cleaner Product2001，9，5： | 1 |
| 18 | Magnesium enrichment improves flue gas scrubbing 显示文摘 | DANIEL X J | 1980 | Power Engineering1980，85，9： | 1 |
| 19 | Value of postoperative surveillance after radical surgery for colorectal cancer: results of a cohort study显示文摘 | Castells A Bessa X Daniels M | 1998 | Dis Colon Rectum1998，41，6： | 1 |
| 20 | Nondestructive and rapid estimation of hardwood foliar nitrogen status using the SPAD-502 chlorophyll meter显示文摘 | Scott X Changa Daniel J | 2003 | Forest Ecol Manag2003，181，： | 1 |
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