|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Understanding the genetic and epigenetic architecture in complex network of rice flowering pathways显示文摘尽管 flowering 时间控制的分子的基础很好在长天(LD ) 内被把,种 Arabidopsis,它在短天(SD ) 内大部分仍然是未知的植物米饭。瑞斯 flowering 时间(标题日期) 是为季节改编和谷物产量的一个重要农学的特点,它被基因、环境的因素影响。在最后十年期间,作为被识别的、著名进步在探索上被取得了的成花素的性质,成花素基因表示怎么样,遗传上控制。然而,在象 FLOWERING 那样的某些关键 flowering 综合者的 Arabidopsis 表示,地点 C (FLC ) 和 FLOWERING 地点 T (英尺) 被各种各样的染色质修正 epigenetically 也调整几乎不在这个方面上在米饭被知道直到很最近。这评论在米饭 flowering 时间控制总结了基因网络和染色质修正的进展,试图给一个完全的看法基因并且在米饭 flowering 小径的复杂网络的 epigenetic 建筑学。 | Changhui Sun Dan Chen Jun Fang Pingrong Wang Xiaojian Deng Chengcai Chu | 2014 | Protein & Cell2014，5，12： | 19 |
| 2 | Spontaneous brain activity in chronic smokers revealed by fractional amplitude of low frequency fluctuation analysis: a resting state functional magnetic resonance imaging study显示文摘 | Chu Shuilian Xiao Dan Wang Shuangkun Peng Peng Xie Teng He Yong Wang Chen | 2014 | Chinese Medical Journal2014，，8： | 6 |
| 3 | Coronary heart disease: incidence, risk factors and interventions in Jiaozhou of Shandong province显示文摘 | Yu Hua Li Dan Chu Xianming An Yi Song Tongxun Feng Huixin Lin Peilin Wang Tao Jiang Shaoyan Guo Linlin Xu Fengqiang Liu Zhengke Yang Bin | 2014 | Chinese Medical Journal2014，，12： | 5 |
| 4 | A complete genome assembly of Glaciecola mesophila sp. nov. sequenced by using BIGIS-4 sequencer system显示文摘Using a pyrosequencing-based custom-made sequencer BIGIS-4, we sequenced a Gram-negative bacterium Glaciecola mesophila sp. nov. (Gmn) isolated from marine invertebrate specimens. We generated 152043 sequencing reads with a mean high-quality length of 406 bp, and assembled them using the BIGIS-4 post-processing module. No systematic low-quality data was detected beyond expected homopolymer-derived errors. The assembled Gmn genome is 5144318 bp in length and harbors 4303 annotated genes. A large number of metabolic genes correspond to various nutrients from surface marine invertebrates. Its abundant cold-tolerant and cellular signaling and related genes reveal a fundamental adaptation to low-temperature marine environment. | YUAN LiNa REN LuFeng LI YunTao HAN WeiJing YU Yong CHU YaNan LIU GuiMing YU Dan TENG MingJing WANG Liang WANG XuMin ZHOU XiaoGuang YU YuDe YU Jun | 2011 | Science China(Life Sciences)2011，54，9： | 4 |
| 5 | Conophylline Promotes the Proliferation of Immortalized Mesenchymal Stem Cells Derived from Fetal Porcine Pancreas (iPMSCs)显示文摘Conophylline, is a bis (indole) alkaloid consisting of two pentacyclic aspidosperma skeletons, isolated from Tabernaemontana divaricata, which has been found to induce β-cell differentiation in rat pancreatic acinar carcinoma cells and in cultured rat pancreatic tissue. However, the precise role of conophylline in the growth and survival of immortalized pancreatic mesenchymal stem cells (iPMSCs) derived from fetal porcine pancreas were not understood at present. To determine whether this molecule is involved in controlling the proliferation of iPMSCs, we examined the effects of conophylline on iPMSCs. We found that conophylline can robustly stimulate iPMSCs proliferation, even promote their potential differentiation into islet-like clusters analyzed by cell counting, morphology, RT-PCR and real-time PCR, Western blotting, glucose-stimulated insulin release and insulin content analysis. The effects of conophylline were inhibited by LY294002, which is the inhibitor of the PI3K pathway. These results suggest that conophylline plays a key role in the regulation of cell mass proliferation, maintenance of the undifferentiated state of iPMSCs and also promotes iPMSCs differentiated into insulin-producing cells. | ZHANG Hui-ru LI Dan CAO Hui Lü Xiao CHU Yuan-kui BAI Yao-fu JIN Ya-ping PENG Sha DOU Zhong-ying HUA Jin-lian | 2013 | Journal of Integrative Agriculture2013，12，4： | 3 |
| 6 | An Improved and Convenient Procedure for the Synthesis of Ozagrel显示文摘A novel approach to the synthesis of ozagrel is described. The target compound isconveniently prepared from the commercially available material, 1,1-carboxyldiimidazole (CDI)through the condensation and hydrolyzation. | Chun GUO Xiao Dan LIU Zhen Gang XIE Chu Jun LI | 2006 | Chinese Chemical Letters2006，17，2： | 3 |
| 7 | Association between 5-hydroxytryptamine transporter gene-linked polymorphic region and smoking behavior in Chinese males显示文摘背景烟草使用是为众多的健康问题的主要风险因素。然而,没有治疗,仅仅, 5% 吸烟者能成功地由于烟碱的高度上瘾的性质停止。因为烟碱增加大脑血清素分泌物,烟碱退却减少血清素层次,和一个选择血清素举起禁止者反对反应到烟碱退却, serotoninergic 系统可以涉及吸行为。血清素 transporter (5-HTT ) 是最重要的蛋白质,当它调整在 synaptic 的集中劈开的血清素。在 5-HTT 基因的在上游的规章的区域有多型性,命名 5-hydroxytryptamine transporter gene-Iinked poyymorphic 区域(5-HTTLPR ) 。与 L 等位基因相比,多型性的 S 等位基因与 5-HTT 基因的减少的抄写效率被联系。在这研究,我们在中国 males.Methods 聚合酶链反应限制碎片长度多型性(PCR-RFLP ) 调查了在这基因多型性和吸烟行为之间的关系被执行在 144 个吸烟者和 135 个匹配年龄的健康不抽烟的人发现 5-HTTLPR 基因多型性。一张问询表在所有招募的 subjects.Results 被完成 L/L (15.3% 对 5.2%) 和 S/L (50.0% 对 33.3%) 的比例遗传型在不抽烟的人比那在吸烟者是显著地更高的(2=21.9;P < 0.01 ) 。机会比率(或) 到年龄,教育,吸烟的家庭成员和朋友的效果,和白酒吸入调整了是 2.9 (95%CI 1.78-4.80 ) 。在吸烟者,香烟 / 天的数字(L/L 对 S/L 对 S/S:28+12 对 20 癡潩 ? 湩 ? | CHU Shui-lian XIAO Dan WANG Chen JING Hang | 2009 | Chinese Medical Journal2009，，12： | 3 |
| 8 | The first data release(DR1) of the LAMOST regular survey显示文摘The Large sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST) general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio(SNR) ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters: late A,FGK-type stars with high quality spectra(1 061 918 entries), A-type stars(100 073 entries), and M-type stars(121 522 entries). This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided. | A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo | 2015 | Research in Astronomy and Astrophysics2015，15，8： | 2 |
| 9 | Proteomic analysis for detecting serum biomarkers related to smoking in humans显示文摘 | XIAO Dan ZHAO Li-juan CHU Shui-lian JING Hang WANG Chen | 2012 | Chinese Medical Journal2012，，17： | 2 |
| 10 | Fluorescence enhancement of Tb^(3+) complexes by adding silica-coated silver nanoparticles显示文摘Six kinds of terbium ternary complexes with halo-benzoic acids were synthesized. Their compositions were determined by C, H elemental analyzer and EDTA titration. The infrared spectra, ultraviolet absorption spectra, and fluorescence spectra were also measured to identify the complexes. Elemental analysis showed that the compositions of these complexes were Tb(p-Br BA)3?H2O, Tb(p-Cl BA)3?2H2O, Tb(p-FBA)3?H2O, Tb(o-FBA)3?2H2O, Tb(o-Cl BA)3?H2O, and Tb(o-Br BA)3?H2O, respectively. The monodispersed Ag@Si O2 core-shell nanoparticles with silica thicknesses of 10, 15, and 25 nm were successfully prepared and characterized by transmission-electron microscopy. Fluorescence intensities of the complexes were detected before and after Ag@Si O2 core-shell nanoparticles were added; the enhancement times were related to the silica-shell thickness. The fluorescence enhancement times were largest when the thickness of the silica shell was 25 nm. The mechanism may be attributed to the localized surface-plasmon resonance. Furthermore, the enhancement effect of terbium fluoro-benzoate complexes was the strongest in these complexes. This result may be attributed to the hydrogen bond between the hydroxyl on the surface of the silica shell and the fluorine atom. | Dan Zhou Xuemei Lin Ailing Wang Jingjing Li Yanrong Qu Haibin Chu Yongliang Zhao | 2015 | Science China Chemistry2015，58，6： | 2 |
| 11 | Expression ofα2-Na/K-ATPase in C57BL/6J Mice Inner Ear and Its Relationship with Age-related Hearing Loss显示文摘K^(+)cycling in the cochlea is critical to maintain hearing.Many sodium-potassium pumps are proved to participate in K^(+)cycling,such as Na/K-ATPase.Theα2-Na/K-ATPase is an important isoform of Na/K-ATPase.The expression ofα2-Na/K-ATPase in the cochlea is not clear.In this study,we used C57BL/6 mice as a model of presbycusis and implemented immunohistochemistry staining and quantitative real time-PCR,and theα2-Na/K-ATPase expression pattern was confirmed in the inner ear.It was foundα2-Na/K-ATPase was expressed widely in cochlea and its mRNA and protein expression was gradually reduced with aging(4-,14-,26-and 48-weeks old mice).We suspected that,the down-regulation ofα2-Na/K-ATPase expression might be associated with the remodeling of K^(+)cycling,degeneration of morphological structure and decrease of hearing function in aging C57 mice.In conclusion,we speculated that the reduction ofα2-Na/K-ATPase might play an important role in the pathogenesis of age-related hearing loss. | Yun LIU Han-qi CHU Yan-bo SUN Dan BING Liang-qiang ZHOU Jin CHEN Qing-guo CHEN Zhi-hui DU | 2021 | Current Medical Science2021，41，1： | 2 |
| 12 | The prevalence of dementia in urban and rural areas of China显示文摘 | Jianping Jia Fen Wang Cuibai Wei Aihong Zhou Xiangfei Jia Fang Li Muni Tang Lan Chu Youlong Zhou Chunkui Zhou Yong Cui Qi Wang Weishan Wang Peng Yin Nan Hu Xiumei Zuo Haiqing Song Wei Qin Liyong Wu Dan Li Longfei Jia Juexian Song Ying Han Yi Xing Peijie Y | 2013 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2013，，： | 2 |
| 13 | 查看详情显示文摘 | Zhang J Chu T S Dong S L Yuan S P Fu A E Dan Y B | | 0，，： | 1 |
| 14 | Creation of fragrant sorghum by CRISPR/Cas9显示文摘Sorghum,the fifth largest cereal crop,has high value as a staple food and raw material for liquor and vinegar brewing.Due to its high biomass and quality,it is also used as the second most planted silage resource.No fragrant sorghums are currently on the market.Through CRISPR/Cas9-mediated knockout of Sb BADH2,we obtained sorghum lines with extraordinary aromatic smell in both seeds and leaves.Animal feeding experiments showed that fragrant sorghum leaves were attractable.We believe this advantage will produce great value in the sorghum market for both grain and whole biomass forage. | Dan Zhang Sanyuan Tang Peng Xie Dekai Yang Yaorong Wu Shujing Cheng Kai Du Peiyong Xin Jinfang Chu Feifei Yu Qi Xie | 2022 | Journal of Integrative Plant Biology2022，64，5： | 1 |
| 15 | A novel reciprocal loop between microRNA-21 and TGFβRIII is involved in cardiac fibrosis显示文摘 | Haihai Liang Chun Zhang Tao Ban Yu Liu Liu Mei Xianmei Piao Dan Zhao Yanjie Lu Wenfeng Chu Baofeng Yang | 2012 | International Journal of Biochemistry and Cell Biology2012，，12： | 1 |
| 16 | MicroRNAs as potential therapeutic targets for pancreatic cancer显示文摘Pancreatic cancer is one of the most aggressive malignancies. The poor prognosis of pancreatic cancer patients is mainly attributed to low diagnostic rate at the early stage, highly aggressive nature coupled with the inadequate efficacy of current chemotherapeutic regimens. Novel therapeutic strategies are urgently needed for pancreatic cancer. MicroRNAs (miRNAs) play an important regulatory role in key processes of cancer development. The aberrant expression of miRNAs is often involved in the initiation, progression, and metastasis of pancreatic cancer. The discovery of tumor suppressor miRNAs provides prospects for the development of a novel treatment strategy for pancreatic cancer. We reviewed recent progress on the understanding of the role of miRNAs in pancreatic cancer, highlighted the efficient application of miRNAs-based therapies for pancreatic cancer in animal models and clinical trials, and proposed future prospects. This review focuses on the promise of integrating miRNAs into the treatment of pancreatic cancer and provides guidance for the development of precision medicine for pancreatic cancer. | Xiangyu Chu Dan Wei Xinxin Liu Di Long Xiaodong Tian Yinmo Yang | 2022 | Chinese Medical Journal2022，，1： | 1 |
| 17 | Data release of the LAMOST pilot survey显示文摘This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects. | A-Li Luo Hao-Tong Zhang Yong-Heng Zhao Gang Zhao Xiang-Qun Cui Guo-Ping Li Yao-Quan Chu Jian-Rong Shi Gang Wang Jian-Nan Zhang Zhong-Rui Bai Xiao-Yan Chen Feng-Fei Wang Yan-Xin Guo Jian-Jun Chen Bing Du Xiao Kong Ya-Juan Lei Yin-Bi Li Yi-Han Song Yue Wu Yan-Xia Zhang Xin-Lin Zhou Fang Zuo Peng Du Lin He Wen Hou Yi-Qiao Dong Jian Li Guang-Wei Li Shuang Li Jing Song Yuan Tian Meng-Xin Wang Yong-Hui Hou Zhi-Ying Huo Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua Li Qi Li Yin-Dun Mao Zheng-Hong Tang Qing-Sheng Tao Liang-Ping Tu Da-Qing Wang Dan Wang Jian-Ping Wang Lei Wang Shou-Guan Wang Shu-Qing Wang Ya-Nan Wang You Wang Yue-Fei Wang Ming-Zhi Wei Xiang-Xiang Xue Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu De-Hua Yang Shi-Hai Yang Zheng-Qiu Yao Yong Yu Hui Yuan Chao Zhai En-Peng Zhang Jing Zhang Li-Ping Zhang WeiZhang Yong Zhang Zhen-Chao Zhang Ming Zhao Fang Zhou Yong-Tian Zhu Jie Zhu Si-Cheng Zou | 2012 | Research in Astronomy and Astrophysics2012，12，9： | 1 |
| 18 | Expression patterns of Cavl.3 channels in the rat cochlea显示文摘尽管 CaV1.3 隧道被知道在听觉的系统为 neuronal 刺激和信号 transduction 必要,他们在蜗的表达式模式仍然不充分被理解,特别地在非感觉的房间被定位的区域。我们执行了 immunohistochemistry,在老鼠蜗识别 CaV1.3 隧道的表示和分发的西方的弄污和反向的抄写聚合酶链反应(RT-PCR ) 。Immunohistochemistry 表明 CaV1.3 隧道是局部性的在里面外部毛细胞(OHC ) ,内部毛细胞(IHC ) ,异色边缘薄片 spiralis,螺线中心房间,螺线系带(SL ) ,和条纹 vascularis (STV ) 。RT-PCR 并且西方的弄污的结果证明 CaV1.3 隧道有一个织物特定的表示模式。当 CaV1.3 隧道的中等水平在 SL 和 STV 被观察时, CaV1.3 mRNA 和蛋白质强烈地在基部的膜和螺线中心被表示。我们的学习 preliminarily 在老鼠蜗揭示了 CaV1.3 隧道的表示模式,提供关于在圆周的 CaV1.3 隧道的角色的进一步的研究的一个理论基础听觉的系统。 | Jin Chen Hanqi Chu Hao Xiong Qingguo Chen Liangqiang Zhou Dan Bing Yun Liu Yan Gao Shaoli Wang Xiaowen Huang Yonghua Cui | 2012 | Acta Biochimica et Biophysica Sinica2012，44，6： | 1 |
| 19 | Synthesis and evaluation of benzylisoquinoline derivatives for their inhibition on pancreatic lipase and preadipocyte proliferation显示文摘The present study was designed to synthesize and evaluate a series of benzylisoquinoline derivatives. These compounds were synthesized by Bischler-Napieralski cyclization to yield 1-benzyl-3,4-dihydroisoquinolines, and the products were obtained by reductions. All these compounds were identified by MS, 1H NMR and 13 C NMR. The inhibitory activities on pancreatic lipase and preadipocyte proliferation for the synthesized compounds and alkaloids from Nulembo nucifera were assessed in vitro. Most of the compounds showed inhibitory activities on both pancreatic lipase and preadipocyte proliferation. Particularly, compounds 7p-7u and 9d-9f exhibited significant inhibitory activity on pancreatic lipase while compounds 7c, 7d, 7f, 7g, 7i, and 7j potently inhibited the proliferation of 3T3-L1 preadipocytes. Our results provided a basis for future evaluation and development of these compounds as leads for therapeutics for human diseases. | TIAN Feng LV Hao-Yu ZOU Ji-Long WANG Yi DUAN Meng-Jun CHU Xiao-Qin LI Dan ZHU Liang JIANG Jian-Qin | 2016 | Chinese Journal of Natural Medicines2016，14，5： | 1 |
| 20 | miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor 显示文摘 | Chu B Zhong L Dan S | 2015 | J Mol Cell Biol2015，7，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员