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| 1 | Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications显示文摘Rheumatoid arthritis(RA) is an autoimmune disease, resulting in a chronic, systemic inflammatory disorder. It may affect many tissues and organs, but it primarily affects the flexible joints. In clinical practice patient care generates many questions about diagnosis, prognosis, and treatment. It is challenging for health care specialists to keep up to date with the medical literature. This review summarizes the pathogenesis, the polymorphisms of interleukin and interleukin genes and the standard available and possible future immunologictargets for RA treatment. The identification of diseaseassociated interleukin and interleukin receptor genes can provide precious insight into the genetic variations prior to disease onset in order to identify the pathways important for RA pathogenesis. The knowledge of the complex genetic background may prove useful for developing novel therapies and making personalized medicine based on the individual's genetics. | Lili Magyari Dalma Varszegi Erzsebet Kovesdi Patricia Sarlos Bernadett Farago Andras Javorhazy Katalin Sumegi Zsolt Banfai Bela Melegh | 2014 | World Journal of Orthopedics2014，5，4： | 17 |
| 2 | Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis显示文摘BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the disease.AIM To quantify the association between subgroups of BMI and the severity and mortality of AP.METHODS A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number CRD42017077890.RESULTS A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI < 18.5 had no significant effect on severity;however, BMI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality is almost equal in the normal BMI and BMI 25-30 subgroups. A BMI >30 results in a three times higher risk of mortality in comparison to a BMI < 30(OR = 2.89, 95%CI: 1.10-7.36, P = 0.026).CONCLUSION Our findings confirm that a BMI above 25 increases the risk of severe AP, while a BMI > 30 raises the risk of mortality. A BMI < 18.5 carries an almost two times higher risk of mortality in AP. | Dalma Dobszai Péter Mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group | 2019 | World Journal of Gastroenterology2019，25，6： | 11 |
| 3 | Family-level leaf nitrogen and phosphorus stoichiometry of global terrestrial plants显示文摘Leaf nitrogen(N) and phosphorus(P) concentrations are critical for photosynthesis, growth, reproduction and other ecological processes of plants. Previous studies on large-scale biogeographic patterns of leaf N and P stoichiometric relationships were mostly conducted using data pooled across taxa, while family/genus-level analyses are rarely reported. Here, we examined global patterns of family-specific leaf N and P stoichiometry using a global data set of 12,716 paired leaf N and P records which includes 204 families, 1,305 genera, and 3,420 species. After determining the minimum size of samples(i.e., 35 records), we analyzed leaf N and P concentrations, N:P ratios and N^P scaling relationships of plants for 62 families with 11,440 records. The numeric values of leaf N and P stoichiometry varied significantly across families and showed diverse trends along gradients of mean annual temperature(MAT) and mean annual precipitation(MAP). The leaf N and P concentrations and N:P ratios of 62 families ranged from 6.11 to 30.30 mg g–1, 0.27 to 2.17 mg g–1, and 10.20 to 35.40, respectively. Approximately 1/3–1/2 of the families(22–35 of 62) showed a decrease in leaf N and P concentrations and N:P ratios with increasing MAT or MAP, while the remainder either did not show a significant trend or presented the opposite pattern. Family-specific leaf N^P scaling exponents did not converge to a certain empirical value, with a range of 0.307–0.991 for 54 out of 62 families which indicated a significant N^P scaling relationship. Our results for the first time revealed large variation in the family-level leaf N and P stoichiometry of global terrestrial plants and that the stoichiometric relationships for at least one-third of the families were not consistent with the global trends reported previously. The numeric values of the family-specific leaf N and P stoichiometry documented in the current study provide critical synthetic parameters for biogeographic modeling and for further studies on the physiological and ecological mechanisms underlying the nutrient use strategies of plants from different phylogenetic taxa. | Di Tian Zhengbing Yan Suhui Ma Yuehong Ding Yongkai Luo Yahan Chen Enzai Du Wenxuan Han Emoke Dalma Kovacs Haihua Shen Huifeng Hu Jens Kattge Bernhard Schmid Jingyun Fang | 2019 | Science China(Life Sciences)2019，62，8： | 7 |
| 4 | Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease显示文摘 | ValterDonadon MassimilianoBalbi Maria DalMas PietroCasarin GiorgioZanette | 2010 | Liver International2010，，5： | 3 |
| 5 | Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells显示文摘 | Katharina Timper Dalma Seboek Michael Eberhardt Philippe Linscheid Mirjam Christ-Crain Ulrich Keller Beat Müller Henryk Zulewski | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 2 |
| 6 | Multiwalled carbon nanotube/polymer nanocomposites:processing and properties显示文摘 | Chazeau L Gauthier C | 2005 | Journal of Polymer Science Part B:Polymer Physics2005，43，10： | 1 |
| 7 | Variations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reductionl-3显示文摘 | Dalmas E Rouault C Abdennour M | 2011 | Am J Chn Nutr2011，94，2： | 1 |
| 8 | On the method of determination of strain energy release rate during fatigue delamination in composite materials显示文摘 | Dalmas D Laksimi A | | 0，，05： | 1 |
| 9 | Multiwalled carbon nanotube/polymer nanocomposites:Processing and properties 显示文摘 | Dalmas F Chazeau L Gauthier C | 2005 | J Polym Sci ( Part B) : Polym Phys2005，43，10： | 1 |
| 10 | Activa- tion of expressed KCNQ potassium currents and native neuro- nal M-type potassium currents by the anti-convulsant drug retigabine显示文摘 | TATULIAN L DALMAS P ABOGADIE F C | 2001 | J Neurosci2001，21，15： | 1 |
| 11 | Role of urapidil in the treament of acute hypertension显示文摘 | LEHOT J BONNEFOV E DALMAS J P | 1995 | Cah Anesthesiol1995，43，1： | 1 |
| 12 | CD14dimCD16 + and CD14 + CD16 + monocytes in obesity and during weight loss:rela- tionships with fat mass and subclinical atherosclemsis 显示文摘 | Poitou C Dalmas E Renovato M | 2011 | Arterio- scler Thromb Vasc Biol2011，31，10： | 1 |
| 13 | Patient-ventilator interactions during partial ventilatury support:a prelirrfinary study comparing the efects of ad aptive support ventilation with synehronlzed intermittent mandatory ventilation plus inspiratory pressure support显示文摘 | Tassaux D Dalmas E GratadonrP | 2002 | Crit Care Med2002，30，4： | 1 |
| 14 | Post-ischemic diastolic dysfunction显示文摘 | March SC Dalmas S Philbin DM | 1994 | J Cardiothorac Vasc Anesth1994，8，6： | 1 |
| 15 | Jeiunal secretory effect of intraduodenal food in humans:A comparison of mixed nutrient proteins lipids and carbohydrates显示文摘 | Miazza B Dalma R | 1985 | Gastroent1985，88，： | 1 |
| 16 | Susceptibility to ulcerative colitis in Hungarian patients determined by gene-gene interactions显示文摘AIM:To study the inflammatory bowel disease-5 locus(IBD5)and interleukin-23 receptor(IL23R)gene variants in UC patients and test for gene-gene interaction.METHODS:The study population(n=625)was comprised of 320 unrelated ulcerative colitis(UC)patients with Caucasian origin and 316 age-and gendermatched,healthy controls.Five variants in the IBD5 locus(IGR2198a_1 rs11739135,IGR2096a_1 rs12521868,IGR2230a_1 rs17622208,SLC22A4 rs1050152 and SLC22A5 rs2631367)and two of the IL23R gene(rs1004819,rs2201841)were analysed.PCR and restriction fragment length polymorphism methods were used for genotyping,the SLC22A4 rs1050152 genotypes were determined by direct sequencing.Interactions and specific genotype combinations of the seven variants were tested by binary logistic regression analysis.The IL23R genotypes were stratified by IBD5 genotypes for further interaction analyses.RESULTS:For the IL23R rs1004819 A allele we found significantly higher allele frequency(P=0.032)in UC patients compared to control subjects.The SNP rs1004819 showed significant association with UC risk for carriers(P=0.004,OR=1.606;95%CI:1.160-2.223)and the SNP rs2201841 for homozygotes(P=0.030,OR=1.983;95%CI:1.069-3.678).Individually none of the IBD5 markers conferred risk to UC development.There was no evidence for statistical interaction either between IBD5 loci and IL23R genes using logistic regression analysis.After genotype stratification,we could detect a positive association on the background of rs1004819 A allele for SLC22A4 T,SLC22A5 C,IGR2198a_1 C or IGR2096a_1 T allele,the highest OR was calculated in the presence of SLC22A4T allele(P=0.005,OR=2.015;95%CI:1.230-3.300).There was no association with UC for any combinations of rs1004819 and IGR2230a_1.The IL23R rs2201841homozygous genotype and IBD5 carrier status together did not confer susceptibility for UC.CONCLUSION:The present study has shown that UC susceptibility genes are likely to act in a complex interactive manner similar to CD. | Patricia Sarlos Dalma Varszegi Veronika Csongei Lili Magyari Luca Jaromi Lajos Nagy Bela Melegh | 2014 | World Journal of Gastroenterology2014，20，1： | 1 |
| 17 | 显示文摘 | Dalmas F Cavaille J Y Gauthier C | 2007 | Composites Science and Technology2007，67，： | 1 |
| 18 | Magnesium selective ion channels显示文摘 | Dalmas O | 2007 | Biophys J2007，93，11： | 1 |
| 19 | Comparison of MMPI profiles in medically and psychological based insomnias显示文摘 | DALMA K S ROSALIND D C | 1997 | Psychological Research1997，70，1： | 1 |
| 20 | Patient ventilator interactions during partial ventilatory support:a preliminary study comparing the effects of adaptive support ventilation with synchronized intermittent mandatory ventilation plus inspiratory pressure support显示文摘 | Tassaux D Dalmas E Gratadour P | 2002 | Crit Care Med2002，30，4： | 1 |
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