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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | Electrochemical and in situ X-ray diffraction studies of the reaction of lithium with tin oxide composites显示文摘 | COURTNEY I A DAHN J R | 1997 | J Electrochem Soc1997，144，： | 2 |
| 3 | Structure and electrochemistry of LiMO2 ( M = Ti, Mn, Fe, Co, Ni ) prepared by mechanochemical synthesis 显示文摘 | OBROVAC M N MAO O DAHN J R | 1998 | Solid State Ionics1998，，112： | 2 |
| 4 | Study of irreversible capacities for Li insertion in hard and graphitic carbons显示文摘 | Xing W Dahn J R | 1997 | J Electrochemical Society1997，144，4： | 1 |
| 5 | 显示文摘 | Luo W B Dahn J R | 2009 | Electrochimica Acta2009，54，： | 1 |
| 6 | Studies of the Layered Manganese Bronzes, Na2/3 O2 with M = Co, Ni, Li and Li2/2 O2 Prepared by Ion-exchange 显示文摘 | J M Paulsen J R Dahn | 1999 | Solid State Ionics1999，126，1： | 1 |
| 7 | Reducing carbon in LiFePO4/C composite electrodes to maximize specific energy, volumetric energy, and tap density显示文摘 | Chen Z Dahn J R | 2002 | J Electrochem Soc2002，149，： | 1 |
| 8 | Reducing carbon in LiFePO4/C composite electrodes to maxing specific energy, volumetric energy, and tap density 显示文摘 | Zhaohui C Dahn J R | 2002 | Journal of the Electrochemical Society2002，149，9： | 1 |
| 9 | Layered LiO2 cathode materials for lithium-ion batteries显示文摘 | Lu Zhonghua MacNeil D D Dahn J R | 2001 | Electrochemical and Solid State Lett2001，4，11： | 1 |
| 10 | Structure and electrochemistry of Li (NixCo1-2xMnx) O2 (0 ≤ x≤ 1/2)显示文摘 | Macneil D D Lu Z Dahn J R | 2002 | Electrochemical Soc2002，149，10： | 1 |
| 11 | The effect of boron substitution in carbon on the intercalation of lithium in Lix (B2C1-x )6 显示文摘 | Way B M Dahn J R | 1994 | J Electrochem Soc1994，141，4： | 1 |
| 12 | Li-insertion in hard carbon anode materials for Li-ion batteries 显示文摘 | BUIEL E DAHN J R | 1999 | Electrochim Acta1999，45，： | 1 |
| 13 | A new layered cathode material for rechargeable lithium batteries显示文摘 | Paulsen J M Larcher D Dahn J R | 2000 | J Electrochem Soc2000，147，8： | 1 |
| 14 | Thermal stability of LixCoO2,LixNiO2 and LixMnO2 and consequences for the safety of Li-ion cells显示文摘 | DAHN J R FULLER E W OBROVAC M | 1994 | Solid State Ionics1994，69，： | 1 |
| 15 | Mechanically alloyed Sn-Fe(-C) powders as anode materials for Li-ion batteries--The SnFe2 SnFe3C active/inactive system 显示文摘 | Mao O Dahn J R | 1999 | Journal of the Electrochemical Society1999，146，2： | 1 |
| 16 | Structure and electro- chemistry of the spinel oxides LiTi204 and Li4~TisaO4显示文摘 | COLBOW K M DAHN J R HAERING R R | 1989 | J Power Sources1989，，26： | 1 |
| 17 | Combinatorial investigations of Si- M (M=Cr + Ni,Fe,Mn) thin film negative electrode materials显示文摘 | Fleischauer M D Topple J M Dahn J R | 2005 | Electrochemical and Solid-State Letters2005，8，2： | 1 |
| 18 | In situ X-ray diffraction and electrochemical studies of Lh-xNi02 显示文摘 | LI W REIMERS J N DAHN J R | 1993 | Solid State Ionics1993，67，1： | 1 |
| 19 | Kinetics study of the high potentialrange of lithium-rich transition-metal oxides for lithium-ion batteriesby electrochemical methods显示文摘 | VAN BOMMEL A DAHN J R | 2010 | Electrochem Solid-State Lett2010，13，5： | 1 |
| 20 | Thermal degradation of the support in carbon-supported platinum electrocatalysts for PEM fuel cells 显示文摘 | STEVENS D A DAHN J R | 2005 | Carbon2005，43，： | 1 |
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