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| 1 | 复杂并发症产生在简单并且 polycystic 肝包囊显示文摘 Liver cysts are common,affecting 5%-10% of the population.Most are asymptomatic,however 5% of patients develop symptoms,sometimes due to complications and will require intervention.There is no consensus on their management because complications are so uncommon.The aim of this study was to perform a collected review of how a series of complications were managed at our institutions.Six different patients presenting with rare complications of liver cysts were obtained from Hepatobiliary Units in the United Kingdom and The Netherlands.History and radiological imaging were obtained from case notes and computerised radiology.As a result,1 patient admitted with inferior vena cava obstruction was managed by cyst aspiration and lanreotide;1 patient with common bile duct obstruction was first managed by endoscopic retrograde cholangiopancreatography and stenting,followed by open fenestration;1 patient with ruptured cysts and significant medical co-morbidities was managed by percutaneous drainage;1 patient with portal vein occlusion and varices was managed by open liver resection;1 patient with infected cysts was treated with intravenous antibiotics and is awaiting liver transplantation.The final patient with a simple liver cyst mimicking a hydatid was managed by open liver resection.In conclusion,complications of cystic liver disease are rare,and we have demonstrated in this series that both operative and non-operative strategies have defined roles in management.The mainstays of treatment are either aspiration/sclerotherapy or,alternatively laparoscopic fenestration.Medical management with somatostatin analogues is a potentially new and exciting treatment option but requires further study. | Christian Macutkiewicz Ricci Plastow Melissa Chrispijn Rafik Filobbos Basil A Ammori David J Sherlock Joost PH Drenth Derek A O’Reilly | 2012 | World Journal of Hepatology2012，4，12： | 10 |
| 2 | Cytomegalovirus in inflammatory bowel disease: Asystematic review显示文摘AIM: To identify definitions of cytomegalovirus(CMV) infection and intestinal disease, in inflammatory bowel disease(IBD), to determine the prevalence associated with these definitions.METHODS: We conducted a systematic review and interrogated Pub Med, EMBASE and Cochrane for literature on prevalence and diagnostics of CMV infection and intestinal disease in IBD patients. As medical headings we used 'cytomegalovirus' OR 'CMV' OR 'cytomegalo virus' AND 'inflammatory bowel disease' OR 'IBD' OR 'ulcerative colitis' OR 'colitis ulcerosa' OR 'Crohn's disease'. Both Me SH-terms and free searches were performed. We included all types of English-language(clinical) trials concerning diagnostics and prevalence of CMV in IBD.RESULTS: The search strategy identified 924 citations, and 52 articles were eligible for inclusion. We identified 21 different definitions for CMV infection, 8 definitions for CMV intestinal disease and 3 definitions for CMV reactivation. Prevalence numbers depend on used definition, studied population and region. The highest prevalence for CMV infection was found when using positive serum PCR as a definition, whereas for CMV intestinal disease this applies to the use of tissue PCR > 10 copies/mg tissue. Most patients with CMV infection and intestinal disease had steroid refractory disease and came from East Asia.CONCLUSION: We detected multiple different definitions used for CMV infection and intestinal disease in IBD patients, which has an effect on prevalence numbers and eventually on outcome in different trials. | Tessa EH Römkens Geert J Bulte Loes HC Nissen Joost PH Drenth | 2016 | World Journal of Gastroenterology2016，22，3： | 6 |
| 3 | Prevention of overuse: A view on upper gastrointestinal endoscopy显示文摘Many upper gastrointestinal(GI) endoscopies worldwide are performed for inappropriate indications. This overuse of healthcare negatively affects healthcare quality and puts pressure on endoscopy services. Dyspepsia is one of the most common inappropriate indications for upper GI endoscopy as diagnostic yield is low. Reasons for untimely referral are: unfamiliarity with dyspepsia guidelines,uncertainty about etiology of symptoms, and therapy failure. Unfiltered openaccess referrals feed upper GI endoscopy overuse. This review highlights strategies applied to diminish use of upper GI endoscopies for dyspepsia. First,we describe the impact of active guideline implementation. We found improved guideline adherence, but resistance was encountered in the process. Secondly, we show several forms of clinical assessment. While algorithm use reduced upper GI endoscopy volume, effects of referral assessment of individual patients were minor. A third strategy proposed Helicobacter pylori test and treat for all dyspeptic patients. Many upper GI endoscopies can be avoided using this strategy, but outcomes may be prevalence dependent. Lastly, empirical treatment with Proton pump inhibitors achieved symptom relief for dyspepsia and avoided upper GI endoscopies in about two thirds of patients. Changing referral behavior is complex as contributing factors are manifold. A collaboration of multiple strategies is most likely to succeed. | Judith J de Jong Marten A Lantinga Joost PH Drenth | 2019 | World Journal of Gastroenterology2019，25，2： | 3 |
| 4 | Classification and diagnosis of erythromelalgia and erythermalgia显示文摘 | Michiels J J Drenth JP Van Genderen PJ | 1995 | lnt J Dermatol1995，34，2： | 1 |
| 5 | Hepatitis C vi- rus infection management in 2012 显示文摘 | VAN GULICK J J LAMERS MH DRENTH JP | 2012 | Panminerva Med2012，54，1： | 1 |
| 6 | Structure of Papain显示文摘 | Drenth J Jansonius J N Koekoek R | 1968 | Nature1968，218，： | 1 |
| 7 | A molecular phylogeny of Phytophthora and related oomycetes显示文摘 | COOKE D E L DRENTH A DUNCAN J M | 2000 | Fungal Genetics and Biology2000，30，： | 1 |
| 8 | Endurancerun increases circulating IL-6 and IL-lra but downregulates ex vivoTNF-alpha and IL-1 beta production显示文摘 | DRENTH J P van UUM S H van DEUREN M | 1995 | J Appl Physiol1995，79，5： | 1 |
| 9 | The heat shock factor family from Triticum aestivum in response to heat and other major abiotic stresses and their role in regulation of heat shock protein genes 显示文摘 | Xue GP Sadat S Drenth J | 2014 | Journal of Ex- perimental Botany2014，65，2： | 1 |
| 10 | Classification and diagnosis of erythromelalgia and erythermalgia显示文摘 | Michiels J J Drenth J | 1995 | Int J Dermatol1995，34，2： | 1 |
| 11 | Molecular characterization of the Waxy locus in sorghum显示文摘 | Mcintyre C L Drenth J Gonzalez N | 2008 | Genome2008，51，7： | 1 |
| 12 | A molecular phylogeny of Phytophthora and related oomycetes显示文摘 | COOKE D E L DRENTH A DUNCAN J M | 2000 | Fungal Genet Biol2000，30，1： | 1 |
| 13 | Molecular anal- ysis of MVK mutations and enzymatic activity in hyper- IgD and periodic fever syndrome 显示文摘 | Cuisset L Drenth J P Simon A | 2001 | Eur J Hum Gen- et2001，9，4： | 1 |
| 14 | Iron saturation of serum ferritin in patients with adult onset Still's disease显示文摘 | ten Kate J Drenth JP Kahn MF | 2001 | J Rheumatol2001，28，10： | 1 |
| 15 | Inon saturation of serum ferritin in patients with adult onset Still's disease显示文摘 | Kate J Drenth JP Kahn MF | 2001 | J Rheumatol2001，28，10： | 1 |
| 16 | Pharmacokinetics of a granisetron transdermal system for the treatment of chemo- therapy induced nausea and vomiting显示文摘 | HOWELL J SMEETS J DRENTH HJ | 2009 | J Oncol Pharm Pract2009，15，4： | 1 |
| 17 | A mo- lecular phylogeny of Phytophthora and related oomyce- tes显示文摘 | Cooke D E L Drenth A Duncan J M | 2000 | Fungal Genetics and Biology2000，30，1： | 1 |
| 18 | 24-hour bronchodilationfollowing a single dose of the novel beta 2-agonist oiodatcrol inCOPD显示文摘 | Vail Ncord J Smeets J Drenth B | 2011 | Pulm Pharmaco Ther2011，24，6： | 1 |
| 19 | Phytophthora sojae avirulence genes, RAPD, and RFLP markers used to construct a detailed genetic linkage map显示文摘 | Whisson S C Drenth A Maclean D J | 1995 | Mol Plant-Microbe Interaction1995，，8： | 1 |
| 20 | Nucleation in protein crystallization显示文摘 | Drenth J Haas C | 1998 | Acta Crystallogr Sect D: Biol Crystallogr1998，54，5： | 1 |
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