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| 1 | Learning tasks as a possible treatment for DNA lesions induced by oxidative stress in hippocampal neurons显示文摘Reactive oxygen species have been implicated in conditions ranging from cardiovascular dysfunction,arthritis,cancer,to aging and age-related disorders.The organism developed several pathways to counteract these effects,with base excision repair being responsible for repairing one of the major base lesions(8-oxoG) in all organisms.Epidemiological evidence suggests that cognitive stimulation makes the brain more resilient to damage or degeneration.Recent studies have linked enriched environment to reduction of oxidative stressin neurons of mice with Alzheimer's disease-like disease,but given its complexity it is not clear what specific aspect of enriched environment has therapeutic effects.Studies from molecular biology have shown that the protein p300,which is a transcription co-activator required for consolidation of memories during specific learning tasks,is at the same time involved in DNA replication and repair,playing a central role in the long-patch pathway of base excision repair.Based on the evidence,we propose that learning tasks such as novel object recognition could be tested as possible methods of base excision repair facilitation,hence inducing DNA repair in the hippocampal neurons.If this method proves to be effective,it could be the start for designing similar tasks for humans,as a behavioral therapeutic complement to the classical drug-based therapy in treating neurodegenerative disorders.This review presents the current status of therapeutic methods used in treating neurodegenerative diseases induced by reactive oxygen species and proposes a new approach based on existing data. | Dragos Cīrneci Radu Silaghi-Dumitrescu | 2013 | Neural Regeneration Research2013，8，32： | 7 |
| 2 | Oxidation of cyclohexane promoted by and 显示文摘 | Salomao G C Olsen M H N Drago V | 2007 | Catal Commun2007，8，1： | 1 |
| 3 | A four-parameters equation for predicting enthalpies of adduct formation显示文摘 | Russell S Drago Glenn C Vogel Terence E Needham 1971 | 1971 | J Am Chem Sec1971，17，： | 1 |
| 4 | A case of coinfection in a chronic maxillary sinusitis of odontogenic origin: identifica- tion of Dialister pneumosintes显示文摘 | Drago L Vassena C Saibene A M | 2013 | J Endod2013，39，8： | 1 |
| 5 | Protective action of phosphatidylserine on stress- induced behavioral and autonomic changes in aged rats显示文摘 | Drago F Spadaro F Agata VD Valerio C Grassi M Mauceri F Pennisi G Scapagnini U | 1991 | Neurobiology of Aging1991，12，5： | 1 |
| 6 | Subclinical left ventricular dysfunction in asymptomatic patients with Type Ⅱ diabetes mellitus, related to serum lipids and glycated haemoglobin 显示文摘 | Dragos V Elcftherios N Ann C | 2003 | Clinical Science2003，105，： | 1 |
| 7 | Electroless plating of nickel-phosphorous on surface-modified poly(ethylene terephthalate) films 显示文摘 | DOMENECH S C LIMA J E DRAGO V | 2003 | Applied Surface Science2003，，220： | 1 |
| 8 | Epoxidation of natural propenylbenzenes catalyzed by 显示文摘 | SALOM G C OLSEN M H N DRAGO V | 2007 | Catal Commun2007，，8： | 1 |
| 9 | Electroless plating of nickel-phosphorous on surface-modified poly-(ethylene terephthalate) films 显示文摘 | Domenech S C Lima E J Drago V | 2003 | Applied Surface Science2003，220，1： | 1 |
| 10 | Molecular dimcnsions for adsorptive显示文摘 | WEBSTER C E DRAGO R S ZERNER M C | 1998 | J Am Chem Soc1998，120，22： | 1 |
| 11 | Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib 显示文摘 | Lecis D Drago C Manzoni L | 2010 | Br J Cancer2010，102，12： | 1 |
| 12 | Interferon Antibodies in Patients with Chronic Hepatitis C Virus Infection treated with Recombinant Interfelon Alpha-2a显示文摘 | Bonetti P Diodati G Drago C | 1994 | J Hepatol1994，20，： | 1 |
| 13 | Novel Cobalt(Ⅱ)-catalyzed Oxidative Cleavage of a Carbon-carbon Double Bond显示文摘 | Drago R S Corden B B Barnes C W | 1986 | J Am Chem Soc1986，108，： | 1 |
| 14 | Role for Irrigation and Debridement in Periprosthetic Infections 显示文摘 | Romanb C Logoluso N Drago L | 2014 | Journal of Knee Surgery2014，27，4： | 1 |
| 15 | Immunostimulating effect of oral glutamine 显示文摘 | Gismondo M R Drago L Fassina M C Vaghi I Abbiati R Grossi E | 1998 | Digest Disease and Science1998，43，8： | 1 |
| 16 | Procalcitonin,C-reactive pro- tein,interleukin-6, and soluble intercellular adhesion molecule-1 as markers of postoperative orthopaedic joint prosthesis infections 显示文摘 | Drago L Vassena C Dozio E | 2011 | International Journal of Immunopathology and Pharmacology2011，24，2： | 1 |
| 17 | Eriodictyol prevents early retinal and plasma abnormalities in streptozotocin-induced diabetic rats显示文摘 | Bucolo C Leggio GM Drago F | 2012 | Biochem Pharm2012，84，4： | 1 |
| 18 | A new general approach to derive normalised pressure impulse curves 显示文摘 | Dragos J Wu C | 2013 | International Journal of Impact Engineering2013，62，： | 1 |
| 19 | Acidity and hydro- phobicity ofTS-l显示文摘 | Drago R S Dias S C McGilvray J M | 1998 | J Phys Chem B1998，102，： | 1 |
| 20 | Single-degree-of-freedom approach to incorporate axial load effects on pressure impulse curves for steel columns显示文摘 | Dragos J Wu C | 2015 | Journal of Engineering Mechanics2015，141，04： | 1 |
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