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| 1 | A review on medicinal importance,pharmacological activity and bioanalytical aspects of beta-carboline alkaloid 'Harmine'显示文摘Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body fluids.Harmine was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine ring.Harmine has various types of pharmacological activities such as antimicrobial,antifungal,antitumor,cytotoxic, antiplasmodial,antioxidaant,antimutagenic,antigenotoxic and hallucinogenic properties.It acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor,enhances insulin sensitivity and also produces vasorelaxant effect.Harmine prevents bone loss by suppressing osteoclastogenesis.The current review gives an overview on pharmacological activity and analytical techniques of harmine,which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases. | K Patel M Gadewar R Tripathi SK Prasad Dinesh Kumar Patel | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 17 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | 焊接参数对搅拌摩擦焊接AA2219-T87材料韧性、洋葱圆环的断裂行为的影响(英文)显示文摘与熔焊相比,搅拌摩擦焊可以更好地保持材料的韧性和塑性,提高焊接的抗裂稳定性。本研究旨在提高焊接接头的延性和强度。刀具廓形在保持延性、分析金属流动行为和确定断裂起始点等方面起着重要作用。分析了洋葱圆环不同区域的微观结构,得出了洋葱圆环强度与金属流型的关系。结果表明,洋葱圆环强化了焊缝熔核。肩部和锥形螺纹型线刀具具有优异的力学性能。显微硬度数据表明,断口经过热影响区和热机械影响区等低硬度区。扫描电镜图像显示了细长的晶粒和韧窝,证实了断裂为韧性断裂。 | Dinesh KUMAR R S MUTHUKUMARAN Vincent XAVIER T VENKATESWARAN D SIVAKUMAR | 2019 | Journal of Central South University2019，26，9： | 2 |
| 4 | Characterization of Grafted Chitosan Films 显示文摘 | Dinesh K S Alok R R | 1998 | Carbohydrate Polymer1998，36，： | 1 |
| 5 | Large mammary hamartoma with focal invasive ductal carcinoma 显示文摘 | Pervatikar SK Rao R Dinesh US | 2009 | Indian J Pathol Microbiol2009，52，2： | 1 |
| 6 | A Comparative Study of the Formulations and Benchmark Problems for the Topology Optimization of Compliant Mechanisms显示文摘 | Deepak S R Dinesh M Sahu D K | 2009 | Journal of Mechanisms and Robotics2009，2，1： | 1 |
| 7 | Randomly amplified ploymorphic DNA (RAPD) fingerprinting in three species of tilapia 显示文摘 | | 1996 | Aquaculture1996，4，1： | 1 |
| 8 | Fish protein hydrolysates : Proximate composition, amino acid composition, antioxidant activities and applications : A review 显示文摘 | M Chalamaiah B Dinesh kumar R Hemalatha | 2012 | Food Chemistry2012，135，4： | 1 |
| 9 | Assessment of genetic relatedness among mango cultivars of india using RAPD markers显示文摘 | Ravishankar K V Anand L Dinesh M R | 2000 | Journal of Horticultural Science & Biotechnology2000，75，2： | 1 |
| 10 | Assessment of genetic relatedness among mango cultivars of India using RAPD markers 显示文摘 | RAVISHANKAR K V ANAND L DINESH M R | 2000 | Journal of Horticultural Science & Biotechnology2000，75，2： | 1 |
| 11 | High-order incompressible large-eddy simulation of fully inhomo- geneous turbulent flows 显示文摘 | Dinesh A S Travis C F Aditya R C | 2010 | Journal of Computa- tional Physics2010，229，23： | 1 |
| 12 | Modeling and testing of cohesive soil using disturbed state concept显示文摘 | Dinesh R Katti Desai C S | 1995 | Journal of Engineering Mechanics1995，121，5： | 1 |
| 13 | RAPD analysis: an efficient method of DNA fingerprinting in fishes显示文摘 | Dinesh K R Lim T M Chua K L | 1993 | Zoological Science1993，10，： | 1 |
| 14 | Enhancing the bio-efficacy of Debaryomyces hansenii with sodium salts for reducing the blue mould rot in apples显示文摘 | Dinesh S Sharma R R Samuel D V K | 2011 | Indian Phytopathology2011，62，4： | 1 |
| 15 | Long-term influence of leguminous cover crops on the biochemical properties of a sandy clay loam Fluventic Sulfaquent in a humid tropical region of India 显示文摘 | Dinesh R Suryanarayana MA Chaudhuri SG Sheeja TE | 2004 | Soil Tillage Res2004，77，1： | 1 |
| 16 | RAPD analysis:an efficient method of DNA fingerprinting in fishes显示文摘 | DINESH K R LIM T M CHUA K L | 1993 | Zool Sci1993，10，： | 1 |
| 17 | Fish protein hydrolysates: proximate composition, amino acid composition, antioxidant activities and applications: a review显示文摘 | CHALAMAIAH M DINESH KUMAR B HEMALATHA R | 2012 | Food Chemistry2012，135，： | 1 |
| 18 | Experimental investigation of laser transformation hardening of low alloy steel using response surface meth- odology显示文摘 | Dinesh Babu P Buvanashekaran G Balasubramanian K R | 2013 | International Journal of Advanced Manufac- turing Technology2013，67，58： | 1 |
| 19 | Biological control of postharvest diseases of fruit s and vegetables by microbial显示文摘 | SHARMA R R DINESH SINGH RAJBIR SINGH | 2009 | Biological Control2009，50，： | 1 |
| 20 | Biological control of postharvest diseases of fruits and vegetables by microbial antagonists: A review显示文摘 | R Sharma Dinesh Singh Rajbir Singh | 2009 | Biological Control2009，50，： | 1 |
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