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| 1 | Hepatocytic differentiation of mesenchymal stem cells in cocultures with fetal liver cells显示文摘瞄准:为了与胎儿的肝细胞(FLC ) 和可能性在合作文化调查间充质的干细胞(MSC ) 的 hepatocytic 区别膨胀,区分了 hepatocytic 房间。方法:MSC 被制动火箭与绿荧光灯的蛋白质(GFP ) 标记病毒的基因转导变异。同种细胞的显著 MSC 在用与干细胞补充的fibronectin涂的培养皿和媒介刺激条件的肝下面是也有教养的因素( SCF ), hepatocyte 生长因素( HGF ),表皮的生长因素( EGF ),和成纤维细胞生长因素 4 ( FGF-4 )独自一个,或在刚孤立的 FLC 的存在。在合作文化的房间被收获,并且 GFP+ 或 GFP- 房间用荧光被分开激活的房间排序。为肝 specific 标记 cytokeratin-18 (CK-18 ) 的反向的抄写聚合酶链反应(RT-PCR )( 法新社) ,白朊,和 alpha-fetoprotein 在不同房间人口被执行。结果:在指定文化条件下面,与 FLC co 有教养的老鼠 MSC 超过二个星期表示了白朊, CK-18,和 AFP-RNA。在 wk 3, MSC 失去了 hepatocytic 基因表示,可能由于 cocultured FLC 的增生。FLC 也在合作文化和一个很高的生长潜力显示出稳定的肝 specific 基因表情。结论:从骨髓的老鼠 MSC 能面对 FLC 在试管内区分 hepatocytic 房间,在合作文化的 MSC 的存在也为 FLC 的扩大和区别提供有益的环境。 | Claudia Lange Helge Bruns Dietrich Kluth Axel R Zander Henning C Fiegel | 2006 | World Journal of Gastroenterology2006，12，15： | 23 |
| 2 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 4 |
| 3 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D'Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 3 |
| 4 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 5 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 6 | Confidence Interval Estimaters for Parameters Associated with Quantitative Structure Activity Relationship显示文摘 | DIETRICH W S DREYER N D HANSCH C | 1980 | Med Chem1980，23，11： | 1 |
| 7 | Morphology and rheology of polystyrene nanocomposites based upon organoclay显示文摘 | Hoffman B Dietrich C Thomann R | 2000 | Macromol Rapid Commun2000，21，： | 1 |
| 8 | Emotion/cognition-coupling in word recognition memory of depressive patients:an event-related potential study显示文摘 | Dietrich DE Emrich HM Waller C | 2001 | Psychiatry Res2001，96，1： | 1 |
| 9 | T-cell receptor beta chain variability in bone marrow and peripheral blood in severe acquired aplastic anemia 显示文摘 | MANZ C Y DIETRICH P Y SCHNURIGER V | 1997 | Blood Ceils Mol Dis1997，23，1： | 1 |
| 10 | Keys to the families of Cicadomorpha andsubfamilies and tribes of Cicadellidae(Hemiptera :Auchenorrhyncha)显示文摘 | Dietrich C H | 2005 | Florida Entomologist2005，88，4： | 1 |
| 11 | An Arabidopsis aspartic protease functions as an anti-cell death component in repro- duction and embryogenesis 显示文摘 | Ge X Dietrich C Matsuno M | 2005 | EMBO Rep2005，6，： | 1 |
| 12 | Role of endoscopicultrasound (EUS) in the staging of rectal cancer 显示文摘 | JURGENSEN C DIETRICH C F | 2008 | ZGastroenterol2008，46，6： | 1 |
| 13 | A multistage tuberculosis vaccine that confers efficient protection before and after exposure, 显示文摘 | Aagaard C Hoang T Dietrich J | 2011 | Nat Med2011，17，2： | 1 |
| 14 | Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia 显示文摘 | DIETRICH W D ATKINS C M Bramlett H M | 2009 | J Neurotranma2009，26，3： | 1 |
| 15 | Neurological symptoms in aortic dissection:a challenge for neurologists显示文摘 | Gaul C Dietrich W Erbguth FJ | 2008 | Cerebrovasc Dis2008，26，1： | 1 |
| 16 | Confidence interval estimators for parameters associated withquantitative structure/activity relationship显示文摘 | DIETRICH W S DREYER N D HANSCH C | 1980 | Journal of MedicinalChemical1980，23，11： | 1 |
| 17 | Sonographic assessment of splanchnic arteries and the bowel wall显示文摘 | DIETRICH C F JEDRZEJCZYK M IGNEE A | 2007 | Eur JRadiol2007，64，： | 1 |
| 18 | Can axillary reverse map- ping avoid lymphedema in node positive breast cancer patients 显示文摘 | Tausch C Baege A Dietrich D | 2013 | Euro J Surg Oneol2013，39，8： | 1 |
| 19 | Comparison of 2 surgical approaches for volar locking plate osteosynthesis of the distal radius 显示文摘 | Lattmann T Dietrich M Meier C | 2008 | J Hand Surg Am2008，33，7： | 1 |
| 20 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 1 |
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