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| 1 | 85岁及以上老年冠心病患者经皮冠状动脉支架治疗的临床观察显示文摘目的探讨85~94岁冠心病患者经皮冠状动脉支架治疗的疗效和预后。方法回顾性分析90例85岁以上冠心病患者经皮冠状动脉支架治疗的临床和造影特点、住院期间和长期疗效。结果90例中,21例应用金属裸支架(BMs),69例应用药物洗脱支架(DES)。三支病变41例,2支病变21例,单支病变28例。手术成功率为94.4%,术前与术后TIMI-3级血流比例分别为72.2%和94.4%。手术相关并发症为15.6%,主要为冠脉夹层(11.1%)。住院期间主要心血管不良事件(MACE)为7.8%,其中DES组住院期间MACE为5.8%,BMS组为14.3%。DES组出现2例严重出血。86例患者随访1年时,总的MACE为4.6%,其中DES组为6.0%,BMS组没有任何MACE。DES组出现1例脑卒中和1例严重出血。47例患者随访2年时,总的MACE为14.9%,其中DES组MAcE为19.4%,BMS组无任何MACE。DES组1例发生严重出血,BMS组1例发生脑卒中。多因素C0x回归分析表明,肌酐水平和高血压是影响长期预后的重要因素。结论85岁以上冠心病患者经皮冠状动脉支架治疗手术成功率较高,住院期间和长期的MACE事件发生率较低,并存高血压和严重肾功能不全的患者MACE的发生率相对较高。 | 马涵英 周玉杰 Ronald J Dick 赵迎新 吴小滢 梁静 杨丽霞 张琳琳 | 2008 | 中华老年医学杂志2008，27，7： | 8 |
| 2 | Involvement of sweet pepper Ca LOX2 in jasmonate-dependent induced defence against Western flower thrips显示文摘Insect herbivory can seriously hinder plant performance and reduce crop yield. Thrips are minute cell-content-feeding insects that are important vectors of viral plant pathogens, and are serious crop pests. We investigated the role of a sweet pepper (Capsicum annuum) lipoxygenase gene, CaLOX2, in the defense of pepper plants against Western flower thrips (Frankliniella occidentalis). This was done through a combination of in-silico, transcrip-tional, behavioral andchemicalanalyses.Our datashowthat CaLOX2 is involved in jasmonic acid (JA) biosynthesis and mediates plant resistance. Expression of the JA-related marker genes, CaLOX2 and CaPIN II, was induced by thrips feeding. Silencing of CaLOX2 in pepper plants through virus-induced gene silencing (VIGS) resulted in low levels of CaLOX2 transcripts, as well as significant reduction in the accumulation of JA, and its derivatives, upon thrips feeding compared to control plants. CaLOX2-silenced pepper plants exhibited enhanced susceptibility to thrips. This indicates that CaLOX2 mediates JA-dependent signaling, resulting in defenseagainstthrips. Furthermore,exogenous application of JA to pepper plants increased plant resistance to thrips, constrained thrips population development and made plants less attractive to thrips. Thus, a multidisciplinary approach shows that an intact lipoxygenase pathway mediates various components of sweet pepper defense against F. occidentalis. | Sandeep J Sarde Klaas Bouwmeester Jhon Venegas-Molina Anja David Wilhelm Boland Marcel Dicke | 2019 | Journal of Integrative Plant Biology2019，61，10： | 6 |
| 3 | Long-term outcome of patients of over 85 years old with acute coronary syndrome undergoing percutaneous coronary stenting: a comparison of bare metal stent and drug eluting stent显示文摘超过 85 年的背景病人在经皮的冠的干预(一种总线标准) 是未被充分代表的尽管有为一种总线标准的工作分派的增加的试用。在有急性冠的症候群(交流) 的超过 85 年的病人的经皮的冠的 stenting 的长期的安全和功效仍然保持不清楚。而且是否在这特殊 population.Methods 赤裸的金属 stent (BMS ) 和药 eluting stent (DES ) 之间有差别,是未知的,有交流的 80 个病人的一个总数在经历 stenting (BMS 组 n=21 对 DES 组 n=59 ) 的 85 年变老回顾地被学习。在里面医院,一年和包括心脏的死亡的主要不利心脏的事件(权标)的全面临床的后续( 12-36 月),心肌的梗塞,目标损害 revascularization ( TLR )和象击并且另外的主要流血一样的目标容器 revascularization ( TVR )在全部队在二 groups.Results 之间被比较,过程成功率与在93.8%容器一种总线标准以后的 TIMI-3 冠的流动是93.8%,过程联系了复杂并发症是17.5%。在 BMS 组的在里面医院权标的发生更高(14.3% 对 6.8% , P=0.30 ) 。当在 BMS 组没有向时,在 DES 组的权标的 1 年的发生是 7.0% 。为 12-36 月的临床的后续证明从向免费的全面幸存是 82.9% ,在 BMS 组的向的发生更低(5.3% 对 21.1% , P=0.20 ) 。Multivariate 回归分析证明 creatinine 铺平(OR:1.013;95%C1:1.006-1.020;P=0.004 ) 并且高血压(OR:3.201;95%C1:1.000-10.663; P=0.04 ) 是二个主要因素影响在超过 85 年的病人的长期的 MACE.Conclusions 经皮的冠的 stenting 是安全的并且提供好短、长期的功效。有肾的机能障碍和高血压的病人可以有向的相对高的发生。 | MA Han-ying ZHOU Yu-jie Ronald J Dick SHI Dong-mei LIU Yu-yang CHENG Wan-jun GUO Yong-he WANG Jian-long GE Hai-long | 2008 | Chinese Medical Journal2008，，10： | 5 |
| 4 | 他汀药物预治疗对高龄冠心病患者支架术预后的影响显示文摘目的 探讨术前他汀类药物治疗对高龄冠心病患者经皮冠状动脉支架治疗近期和远期预后的影响.方法 回顾性分析90例85岁以上冠心病患者术前他汀应用情况,观察其对预后的影响.结果 90例患者中,33例经皮冠状动脉介入(PCI)术前接受他汀治疗,57例PCI术前未接受他汀治疗.80例(88.9%)为急性冠状动脉综合征.术前接受他汀治疗组血脂异常、既往心肌梗死病史、既往PCI、开口病变、药物涂层支架(DES)植入比例比例略高.住院期间主要心血管不良事件(MACE)发生率要低于术前未接受他汀治疗组(3.0%比10.5%,P=0.05).随访1年时MACE发生率两组相似(6.1%与3.8%,P=0.07).整个研究人群1年生存率较高.结论 他汀预治疗对高龄冠心病支架术后可能降低住院期间MACE,而不一定能改善1年预后. | 马涵英 赵铁夫 张银凤 史宏志 韩红亚 周玉杰 Ronald J Dick | 2010 | 中华医学杂志2010，90，32： | 5 |
| 5 | 肾功能不全与高龄冠脉支架治疗的预后分析显示文摘目的 探讨不同肾功能对高龄冠心病患者经皮冠状动脉支架治疗住院期间和长期预后的影响.方法 回顾性分析90例85岁以上冠心病接受冠脉支架治疗患者主要心血管不良事件和病死率.根据入院时估算的肾小球滤过率水平,患者分为eGFR≥60组(肾功能正常或轻度不全组;n=62)和eGFR〈60组(中重度肾功能不全组;n=28),观察肾功能不全对高龄冠脉介入治疗预后的影响.结果 eGFR〈60组高血压病、目前吸烟状态、既往心肌梗死病史、三支病变、C型病变、术前TIMI0级血流比例略高.住院期间主要心血管不良事件发生率eGFR〈60组要明显高于eGFR≥60组(14.3%vs4.8%;P〈0.05).随访1年时全因死亡率两组相似(4.9%vs4.0%;P〉0.05),但MACE发生率eGFR〈60组仍高于eGFR≥60组(8.0%vs3.3%;P=0.05).整体研究人群1年生存率较高.结论 中重度肾功能不全是影响高龄冠脉支架治疗预后的一个重要危险因素,围手术期应积极地改善患者的肾功能从而改善预后. | 马涵英 赵铁夫 张维君 杨清 刘睿方 柴萌 张鸥 Ronald J Dick | 2011 | 中国急救复苏与灾害医学杂志2011，6，10： | 3 |
| 6 | Variation in composition of predator-attracting allelochemicals emitted by herbivore-infested plants: relative influence of plant and herbivore显示文摘 | Takabayashi J Dicke M Posthumus M A | 1991 | Chemoecology1991，，2： | 2 |
| 7 | Optimizing the selection of bridging particles for reservoir drilling fluids 显示文摘 | Dick M A Heinz T J Svoboda C F | 2000 | SPE 587932000，，： | 1 |
| 8 | Effects of weak layers on particle velocity measurements显示文摘 | Fourney W L Dick R D Wang X J | 1997 | Rock Mechanics and Rock Engineering1997，30，1： | 1 |
| 9 | Impact of flue gas desulfurization-calcium sulfite and gypsum on soil microbial activity and wheat growth显示文摘 | LEE Y B BIGHAM J M DICK W A | 2008 | Soil Science2008，173，： | 1 |
| 10 | Characterizing effective d31 values for PZT from the nonlinear oscillations of clamped-clamped micro-resonators 显示文摘 | DICK A J | 2013 | Journal of Mechanical Engineering2013，59，1： | 1 |
| 11 | Attraction of Colorado potato beetle to herbivore-damaged plants during herbivory and after its termination显示文摘 | BOLTER C J DICKE M VAN LOON J J A | 1997 | Chem Eco11997，23，4： | 1 |
| 12 | The developing cancer stem-cell model: clinical challenges and opportunities显示文摘 | Louis Vermeulen Felipe de Sousa e Melo Dick J Richel Jan Paul Medema | 2012 | Lancet Oncology2012，，： | 1 |
| 13 | A biomechanical com- parison evaluating the use of intermediate screws and cross-link- age in lumbar pediole fixation显示文摘 | Dick J C Jones M P Zdeblick T A | 1994 | J Spinal Disord1994，7，： | 1 |
| 14 | Quantitive C Characterization of Trace Levels of PFOS and PFOA in the Tennesse River显示文摘 | Hansen K J Johnson H O Eldridge J S Butenhoff J L Dick L A | 2002 | Environ Sci Technol2002，36，8： | 1 |
| 15 | Chromian spinel as a petrogenetic indi- cator in abyssal and alpine-type peridotites and spatially associ- ated lavas显示文摘 | Dick H J B Bullen T | 1984 | Contributions to Mineralogy and Petrology1984，86，1： | 1 |
| 16 | GPU ray casting for scalable terrain rendering显示文摘 | Dick C Kruger J Westermann R | 2009 | In Proceedings of Eurographics- Areas Papers2009，，： | 1 |
| 17 | Gram negative sinusitis : a bacteriologic and histologic study in rabbits显示文摘 | Bolger WE Leonard D Dick | 1997 | Am J Rhinol1997，11，1： | 1 |
| 18 | The association between DRD2/ANKK1 and genetically informed measures of alcohol use and problems显示文摘 | Meyers JL Nyman E Loukola A Rose RJ Kaprio J Dick DM | | 0，，03： | 1 |
| 19 | Plant strategies of manipulating predatorprey interactions through allelochemicals :Prospects for applaction in pest control 显示文摘 | DICKE M SABELIS M W TAKABAYASHI J | 1990 | Journal of chemical ecology1990，，： | 1 |
| 20 | Generation and performance of special quasirandom structures for studying the elastic properties of random alloys:Application to Al-Ti显示文摘 | Pezold J V Dick A Friak M | 2010 | Physical Review B2010，81，09： | 1 |
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