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| 1 | Pancreatic neuroendocrine neoplasms: Magnetic resonance imaging features according to grade and stage显示文摘AIM To describe magnetic resonance(MR) imaging features of pancreatic neuroendocrine neoplasms(Pan NENs) according to their grade and tumor-nodes-metastases stage by comparing them to histopathology and todetermine the accuracy of MR imaging features in predicting their biological behavior.METHODS This study was approved by our institutional review board; requirement for informed patient consent was waived due to the retrospective nature of the study. Preoperative MR examinations of 55 Pan NEN patients(29 men, 26 women; mean age of 57.6 years, range 21-83 years) performed between June 2013 and December 2015 were reviewed. Qualitative and quantitative features were compared between tumor grades and stages determined by histopathological analysis.RESULTS Ill defined margins were more common in G2-3 and stage Ⅲ-Ⅳ PanN ENs than in G1 and low-stage tumors(P < 0.001); this feature had high specificity in the identification of G2-3 and stage Ⅲ-Ⅳ tumors(90.3% and 96%, 95%CI: 73.1-97.5 and 77.7-99.8). The mean apparent diffusion coefficient value was significantly lower in G2-3 and stage Ⅲ-Ⅳ lesions compared to well differentiated and low-stage tumors(1.09 × 10-3 mm2/s vs 1.45 × 10-3 mm2/s and 1.10 × 10-3 mm2/s vs 1.53 × 10-3 mm2/s, P = 0.003 and 0.001). Receiving operator characteristic analysis determined optimal cutoffs of 1.21 and 1.28 × 10-3 mm2/s for the identification of G2-3 and stage Ⅲ-Ⅳ tumors, with sensitivity and specificity values of 70.8/80.7% and 64.5/64%(95%CI: 48.7-86.6/60-92.7 and 45.4-80.2/42.6-81.3).CONCLUSION MR features of PanN ENs vary according to their grade of differentiation and their stage at diagnosis and could predict the biological behavior of these tumors. | Riccardo De Robertis Sara Cingarlini Paolo Tinazzi Martini Silvia Ortolani Giovanni Butturini Luca Landoni Paolo Regi Roberto Girelli Paola Capelli Stefano Gobbo Giampaolo Tortora Aldo Scarpa Paolo Pederzoli Mirko D'Onofrio | 2017 | World Journal of Gastroenterology2017，23，2： | 16 |
| 2 | Diffusion-weighted imaging of pancreatic cancer显示文摘Magnetic resonance imaging(MRI) is a reliable and accurate imaging method for the evaluation of patients with pancreatic ductal adenocarcinoma(PDAC). Diffusion-weighted imaging(DWI) is a relatively recent technological improvement that expanded MRI capabilities, having brought functional aspects into conventional morphologic MRI evaluation. DWI can depict the random diffusion of water molecules within tissues(the so-called Brownian motions). Modifications of water diffusion induced by different factors acting on the extracellular and intracellular spaces, as increased cell density, edema, fibrosis, or altered functionality of cell membranes, can be detected using this MR sequence. The intravoxel incoherent motion(IVIM) model is an advanced DWI technique that consent a separate quantitative evaluation of all the microscopic random motions that contribute to DWI, which are essentially represented by molecular diffusion and blood microcirculation(perfusion). Technological improvements have made possible the routine use of DWI during abdominal MRI study. Several authors have reported that the addition of DWI sequence can be of value for the evaluation of patients with PDAC, especially improving the staging; nevertheless, it is still unclear whether and how DWI could be helpful for identification, characterization, prognostic stratification and follow-up during treatment. The aim of this paper is to review up-to-date literature data regarding the applications of DWI and IVIM to PDACs. | Riccardo De Robertis Paolo Tinazzi Martini Emanuele Demozzi Flavia Dal Corso Claudio Bassi Paolo Pederzoli Mirko D'Onofrio | 2015 | World Journal of Radiology2015，7，10： | 14 |
| 3 | Prognostication and response assessment in liver and pancreatic tumors:The new imaging显示文摘Diffusion-weighted imaging(DWI), dynamic contrastenhanced magnetic resonance imaging(DCE-MRI) and perfusion computed tomography(CT) are technical improvements of morphologic imaging that can evaluate functional properties of hepato-bilio-pancreatic tumors during conventional MRI or CT examinations.Nevertheless, the term 'functional imaging' is commonly used to describe molecular imaging techniques, as positron emission tomography(PET)CT/MRI, which still represent the most widely used methods for the evaluation of functional properties of solid neoplasms; unlike PET or single photon emission computed tomography, functional imaging techniques applied to conventional MRI/CT examinations do not require the administration of radiolabeled drugs or specific equipments. Moreover, DWI and DCE-MRI can be performed during the same session, thus providing a comprehensive 'one-step' morphological and functional evaluation of hepato-bilio-pancreatic tumors. Literature data reveal that functional imaging techniques could be proposed for the evaluation of these tumors before treatment, given that they may improve staging and predict prognosis or clinical outcome. Microscopic changes within neoplastic tissues induced by treatments can be detected and quantified with functional imaging,therefore these techniques could be used also for posttreatment assessment, even at an early stage. The aim of this editorial is to describe possible applications of new functional imaging techniques apart frommolecular imaging to hepatic and pancreatic tumors through a review of up-to-date literature data, with a particular emphasis on pathological correlations,prognostic stratification and post-treatment monitoring. | Riccardo De Robertis Paolo Tinazzi Martini Emanuele Demozzi Gino Puntel Silvia Ortolani Sara Cingarlini Andrea Ruzzenente Alfredo Guglielmi Giampaolo Tortora Claudio Bassi Paolo Pederzoli Mirko D'Onofrio | 2015 | World Journal of Gastroenterology2015，21，22： | 10 |
| 4 | 查看详情显示文摘 | M D Reid W J Munro F De Martini | | 0，，03： | 1 |
| 5 | The immune system in the elderly显示文摘 | Ginali L De Martinis M D'Ostilio A | 1999 | Immu- nol Res1999，20，2： | 1 |
| 6 | Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity 显示文摘 | De Martinis M Franceschi C Monti D | 2005 | FEBS Lett2005，579，10： | 1 |
| 7 | Identification of filamentous fungi isolates by MALDI-TOF mass spectrometry: clinical evaluation of an extended reference spectra library显示文摘 | Becker PT de Bel A Martiny D | 2014 | Med Mycol2014，52，8： | 1 |
| 8 | Contextual, Optimal, and Universal Realization of the Quantum Cloning Machine and of the NOT Gate 显示文摘 | DE MARTINI F PELLICCIA D SCIARRINO F | 2004 | Phys Rev Lett2004，92，06： | 1 |
| 9 | Experimental realization of teleporting an unknown pure quantum state via dual classical and Einstein-Podolsky-Rosen channels 显示文摘 | BOSCHI D BRANCA S DE MARTINI F | 1998 | Physical Review Letters1998，80，6： | 1 |
| 10 | Ethylene pro- duction by Botrytis cinerea in vitro and in tomatoes 显示文摘 | Cristeseu S M De Martinis D Hekkert S L | 2002 | Appl Envi- ron Microbiol2002，68，11： | 1 |
| 11 | Silencing gene expression of the ethyleneforming enzyme results in a reversible inhibition of ovule develop- ment in transgenic tobacco plants显示文摘 | de Martinis D Mariani C | 1999 | Plant Cell1999，11，6： | 1 |
| 12 | Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity显示文摘 | De Martinis M Franceschi C Monti D | | 0，，： | 1 |
| 13 | Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity 显示文摘 | De Martinis M Franceschi C Monti D | 2005 | FEBSLett2005，579，10： | 1 |
| 14 | Changes in the expression of surface receptors on lymphocyte subsets in the elderly: quantitative flow cytometric analysis显示文摘 | Ginaldi L De Martinis M D'Ostilio A | 2001 | Am J Hematol2001，67，2： | 1 |
| 15 | The Immune System in the Elderly显示文摘 | Ginali L De Martinis M D'Ostilio A | 1999 | lmmuno Res1999，20，2： | 1 |
| 16 | Chronic antigenic load and apoptosis in immunosenescence显示文摘 | Ginaldi L De Martinis M Monti D | 2005 | Trends Immunol2005，26，： | 1 |
| 17 | In- flammation markers predicting frailty and mortality in the elderly 显示文摘 | De Martinis M Franceschi C Monti D | 2006 | Exp Mol Pathol2006，80，3： | 1 |
| 18 | Experimental realization of teleporting an unknown pure quantum state via dual classical and Einstein-Podolsky-Rosen channels 显示文摘 | Boschi D Branca S De Martini F | 1998 | Phys Rev Lett1998，80，6： | 1 |
| 19 | Cell proliferation and apoptosis in the immune system in the elderly显示文摘 | Ginaldi L De Martinis M D' Ostilio A | 2000 | Immunol Res2000，21，1： | 1 |
| 20 | Effect of vitamin C supplementation against cisplatin-induced toxicity and oxidative DNA damage in rats显示文摘 | De Martinis B S Bianchi M D | 2001 | Pharmacol Res2001，44，4： | 1 |
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