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| 1 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 2 | Characterization of intrapelvic pressure during ureteropyeloscopy with ureteral access sheaths显示文摘 | Jamil Rehman Manoj Monga Jaime Landman David I Lee Tamer Felfela Marius C Conradie Rajamahanty Srinivas Chandru P Sundaram Ralph V Clayman | 2003 | Urology2003，，4： | 2 |
| 3 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 4 | Click chemistry as an efficient synthetic tool for the preparation of novel conjugated polymers显示文摘 | Dirk J V C David O R P Strijdonck G P E | 2005 | Chemistry Common2005，，34： | 1 |
| 5 | Serum a-L-fucosidase:a new marker for the diagnosis of primary hepatic carcinoma显示文摘 | Deugnier Y David V Brissot P | 1984 | Hepatology1984，4，： | 1 |
| 6 | Carbon storage by urban soils in the United States显示文摘 | Richard V P Yesilonis ID David J N | 2006 | Journal of environmentalquality2006，35，4： | 1 |
| 7 | Sorption of tetracycline and chlortetracycline on K-and Ca-Saturated soil clays, humic substances, and Clay-Humic complexes 显示文摘 | Jutta R V P David A L | 2007 | Environ Sci Technol2007，41，： | 1 |
| 8 | The effect of extracellular ice and cryoprotective agenis on the water permeability parameters of human sperm plasma membrane during freezing 显示文摘 | RAMACHANDRA V D DAVID J S KENNETH P R | 2000 | Human Reproduction2000，15，5： | 1 |
| 9 | A method for assessing hydrologic alteration within ecosystems显示文摘 | Brian D Riehter Jeffrey V Baumgartner David P Braun | 1996 | Conservation Biology1996，10，4： | 1 |
| 10 | Subzero water permeability parameters of mouse spermatozoa in the presence of extraceUular ice and cryoprotective agents 显示文摘 | RAMACHANDRA V D DAVID J S KENNETH P R | 1999 | Biology of Reproduction1999，61，： | 1 |
| 11 | Development of the antimicrobial effectiveness test as USP chapter(51)显示文摘 | SCOTT V SUTTON W DAVID P | 2002 | PDA J Pharm Sci Technol2002，56，6： | 1 |
| 12 | Chronlc and recurrent pneumonias in children显示文摘 | David V Katkln J P | 2002 | Semin Respu-Infeet2002，17，1： | 1 |
| 13 | Chronic and recurrent pneumonias in ehilclren显示文摘 | DAVID V KATKIU J P | 2002 | Semin Respir Infect2002，17，1： | 1 |
| 14 | Long-term changesof the zooplankton variability in a turtid environment: theGironde estuary (France) 显示文摘 | DAVID V SAUTOUR B CHARDY P | 2005 | Estuarine Coastal and ShelfScience2005，64，23： | 1 |
| 15 | Role of determinants of cadmium sensitivity in the tolerance of Schizosaccharomyces pombe to cisplatin显示文摘 | PEREGO P WEGHE J V DAVID W O | | 0，，01： | 1 |
| 16 | Knowing when to grow:signals regulating bud dormaney显示文摘 | DAVID P HORVATH JAMES V | 2003 | TRENDS in Plant Science2003，8，11： | 1 |
| 17 | The NIH human microbiome project显示文摘 | NIH HMP Working Group Peterson J Garges S Giovanni M McInnes P Wang L Schloss JA Bonazzi V McEwen JE Wetterstrand KA Deal C Baker CC Di Francesco V Howcroft TK Karp RW Lunsford RD Wellington CR Belachew T Wright M Giblin C David H Mills M Salomon R Mullins C Akolkar B Begg L Davis C Grandison L Humble M Khalsa J Little AR Peavy H Pontzer C Portnoy M Sayre MH Starke-Reed P Zakhari S Read J Watson B Guyer M | 2009 | Genome Res2009，19，12： | 1 |
| 18 | Myasthenia gravis显示文摘 | Jackie P David HJ | 2001 | Lancet2001，357，： | 1 |
| 19 | Diagnostic value of N-terminal pro-B-type natriuretic peptide(NT-proBNP)for left ventrieular dysfunction in patients with chronic kidney disease stage 5 on haemodialysis显示文摘 | David S Kümpers P Seidler V | 2008 | Nephrol Dial Transplant2008，23，4： | 1 |
| 20 | Estimation of incidence and reflection angles from passive polarimetric imagery: extension to out-of-plane scattering显示文摘 | Anand P Vimal T David G V | 2007 | Proc of SHE2007，6682，66820： | 1 |
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