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| 1 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 2 | Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations,in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm(ASCOT-LLA):a multi centre randomised controlled trial显示文摘 | Sever PS Dahl(o)f B Poulter N | 2003 | Lancet2003，361，9364： | 1 |
| 3 | The Hospital Anxiety and Depression Rating Scale:a cross-sectional study of psychometrics and case finding abilities in general practice显示文摘 | Olssφn I Mykletun A Dahl AA | | 0，，： | 1 |
| 4 | Infliximab Inhibits Activation and Effector Functions of Peripheral Blood T Cells in vitro from Patients with Clinically Active Ulcerative Colitis显示文摘 | R. Dahlén H. Strid A. Lundgren S. Isaksson S. Raghavan M. K. Magnusson M. Simrén H. Sj?vall L. ?hman | 2013 | Scand J Immunol2013，，3： | 1 |
| 5 | The antimicrobial effect of calcium hydroxide in root canals pretreated with 5% iodinepotassium iodium显示文摘 | Molander A Reit C Dahlén G | 1999 | Endod Dent Traumatol1999，15，5： | 1 |
| 6 | 5-year follow up of periodontal intraosseous defects treated by root planing or flap surgery显示文摘 | Nilvéus R Dahlén G | 1990 | J Clin Periodontol1990，17，6： | 1 |
| 7 | Anatomy, physiology and function of the nasal cavities in health and disease 显示文摘 | Dahl R Mygind N | 1998 | Adv Drug Deliv Rev1998，29，12： | 1 |
| 8 | Streptococci from root canals in teeth with apical periodontitis receiving endodontic treatment显示文摘 | Chávez De Paz L Svens?ter G Dahlén G | 2005 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2005，100，2： | 1 |
| 9 | Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial显示文摘 | Eriksson BI Dahl OE Rosencher N | 2007 | Lancet2007，370，9591： | 1 |
| 10 | Dissolution of metal tritides in a simulated lung fluid显示文摘 | Cheng Y S Dahl A R Jow H N | 1997 | Health Physics1997，73，4： | 1 |
| 11 | Depres sion in relation to age and gender in the general population the Nord Trondelag Health Study(HUNT)显示文摘 | Stordal E Bjartveit Kruger M Dahl N H | 2001 | Acta Psychi atr Scand2001，104，： | 1 |
| 12 | Microbiological status of root-fil ed teeth with apical periodontitis显示文摘 | Molander A Reit C Dahlén G | | 0，，01： | 1 |
| 13 | A critical period for thyroid hormone action on seasonal changes in reproductive neuroendocrine function in the ewe 显示文摘 | Thrun L A Dahl G E Evans N P | 1997 | Endocrinology1997，138，8： | 1 |
| 14 | The impact of inadequate sleep on children's daytime cognitive function 显示文摘 | DAHL R E RYAN N D MATTY M K | 1996 | Semin Pediatr Neurol1996，3，1： | 1 |
| 15 | Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo-Scandinavian Cardiac Outcomes Trial显示文摘 | Sever P Dahl(o)f B Pouher N | 2006 | Eur Heart J2006，27，24： | 1 |
| 16 | Dabigatran etexi- late versus enoxaparin for prevention of venous thromboembo- lism after total hip replacement: a randomised, double-blind, non-inferiority trial 显示文摘 | Eriksson BI Dahl OE Rosencher N | 2007 | Lancet2007，370，： | 1 |
| 17 | Stress and depression among medical students: a cross-sectional study显示文摘 | DAHL N M JONEBORG N RUNESON B | 2005 | Med Educ2005，39，6： | 1 |
| 18 | The hospital anxiety and depression rating scale:a cross-sectional study of psychometrics and case finding abilities in general practice显示文摘 | Olssφn I Mykletun A Dahl AA | 2005 | BMC Psychiatry2005，5，： | 1 |
| 19 | Trends in low-temperature water-gas shift reactivity on transition metals 显示文摘 | Schumacher N Boisen A Dahl S | 2005 | Journal of Catalysis2005，229，： | 1 |
| 20 | Leukotrienes and lipoxins : structures, biosynthesis, and biological effects显示文摘 | Samuelsson B Dahl~n SE Lindgren JA | 1987 | Science1987，237，4819： | 1 |
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