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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Torsade de pointes due to noncardiac drugs: most patients have easily identifiable risk factors显示文摘 | Zelter D Justo D Halkin A | 2003 | Medicine (Baltimore)2003，82，： | 1 |
| 3 | Torsades de pointes induced by antibiotics显示文摘 | Justo D Zeltser D | 2006 | EurJ Intern Med2006，17，4： | 1 |
| 4 | Torsade de pointes induced by systemic antifungal agents: lessons from a retrospective analysis of published case reports显示文摘 | JUSTO D ZELTSER D | 2006 | Mycoses2006，49，6： | 1 |
| 5 | Inherited variability in a master regulator polymorphism associates with survival in 5-FU treated colorectal cancer patients 显示文摘 | Patients B P Justo L B Cornelia D | 2014 | Mutation Research Fundamental and Molecular Mechanisms of Mutageuesis2014，，766767： | 1 |
| 6 | Torsades de Pointes induced by systemic antifungal agents: lessons from a retrospective analysis of published case reports 显示文摘 | Justo D Zelter D | 2006 | Mycoses2006，49，： | 1 |
| 7 | Drug - induced atrioventricular block: Prognosis after discontinuation of the culprit drug 显示文摘 | Zeltser D Justo D Halkin A | 2004 | J Am Coll Cardiol2004，44，1： | 1 |
| 8 | Stability in an age-structured metapopulation model 显示文摘 | DE CASTRO M L SILVA J A L JUSTO D A R | 2006 | J Math Biology2006，52，： | 1 |
| 9 | QT prolongation and torsades de pointes in patients previously treated with anthraeyclijes显示文摘 | Arbel Y Swartzon M Justo D | 2007 | Anticancer Drugs2007，18，4： | 1 |
| 10 | Torsade de pointes due to noncardiac drugs:most patients have easily identifiable risk factors显示文摘 | ZELTSER D JUSTO D HALKIN A | 2003 | Medicine (Baltimore)2003，82，4： | 1 |
| 11 | Long QT syndrome caused by noncardiac drugs 显示文摘 | Viskin S Justo D Halkin A | 2003 | Prog Cardiovasc Dis2003，45，5： | 1 |
| 12 | Methadone-associatedTorsades de Pointes (polymorphic ventricular tachycardia)in opioid-dependent patients显示文摘 | JUSTO D GAL-OZ A PARAN Y | 2006 | Addiction2006，101，9： | 1 |
| 13 | Torsade de points by antibiotics显示文摘 | JUSTO D ZELTSER D | 2006 | Eur J Intern Med2006，17，4： | 1 |
| 14 | Long QT syndrome caused by noncardiae dnugs显示文摘 | Viskin S Justo D Hakin A | 2003 | Prog Cardiovasc Dis2003，45，： | 1 |
| 15 | Torsade de pointes due to noncardiac drugs: most patients have easily identifiable risk factors显示文摘 | ZELTSER D JUSTO D HALKIN A | 2003 | Medicine(Baltimore)2003，82，4： | 1 |
| 16 | Community - ac- quired pneumonia in immunocompromised older patients: inci- dence, causative organisms and outcome 显示文摘 | Sousa D Justo I Dominguez A | 2013 | Clin Mierobiol Infect2013，19，2： | 1 |
| 17 | Analysis of invertebrate biodiversity in a Philippine framer's irrigated rice field显示文摘 | Schoenly K J Justo H D Barrion A T | 1998 | Environentul Entomology1998，27，： | 1 |
| 18 | Desar- rollo de pan integral con soya, chia, linaza y dcido folico como alimento funcional para la mujer显示文摘 | Justo M B Alfaro A D C Aguilar E C | 2007 | Ar- chivos latinoamericanos de nutricion2007，57，1： | 1 |
| 19 | Long QT syndrome by noncardiac drugs显示文摘 | Viskino S Justo D Halkin A | 2003 | Progr Cardiovasc Dis2003，45，5： | 1 |
| 20 | Torsades de pointes induced by antibiotics显示文摘 | Justo D Zeltser D | 2006 | Eur J Intern Med2006，17，： | 1 |
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