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| 1 | Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease显示文摘AIM: To determine serum vitamin D levels and colonic vitamin D receptor(VDR) expression in inflammatory bowel disease(IBD) and non-IBD patients and correlate these with histopathology.METHODS: Puerto Rican IBD(n = 10) and non-IBD(n = 10) patients ≥ 21 years old scheduled for colonoscopy were recruited. Each patient completed a questionnaire and provided a serum sample and a colonic biopsy of normal-appearing mucosa. For IBD patients, an additional biopsy was collected from visually diseased mucosa. Serum vitamin D levels were measured by ultra-performance liquid chromatography and mass spectrometry. Hematoxylin and eosin stained tissue sections from colonic biopsies were classified histologically as normal or colitis(active/inactive), and scored for the degree of inflammation present(0-3, inactive/absent to severe). Tissue sections from colonic biopsies were also stained by immunohistochemistry for VDR, for which representative diagnostic areas were photographed and scored for staining intensity using a 4-point scale.RESULTS: The IBD cohort was significantly younger(40.40 ± 5.27, P < 0.05) than the non-IBD cohort(56.70 ± 1.64) with a higher prevalence of vitamin D deficiency(40% vs 20%, respectively) and insufficiency(70% vs 50%, respectively). Histologic inflammation was significantly higher in visually diseased mucosa from IBD patients(1.95 ± 0.25) than in normalappearing mucosa from control patients(0.25 ± 0.08, P < 0.01) and from IBD patients(0.65 ± 0.36, P < 0.05) and correlated inversely with VDR expression in visually diseased colonic tissue from IBD patients(r =-0.44, P < 0.05) and from IBD patients with Crohn's disease(r =-0.69, P < 0.05), but not in normal-appearing colonic tissue from control patients or IBD patients. Control and IBD patient serum vitamin D levels correlated positively with VDR expression in normal colon from control and IBD patients(r = 0.38, P < 0.05) and with patient age(r = 0.54, P < 0.01). CONCLUSION: Levels of serum vitamin D correlate positively with colonic VDR expression in visually normal mucosa whereas inflammation correlates negatively with colonic VDR expression in visually diseased mucosa in Puerto Rican patients. | Yamilka Abreu-Delgado Raymond A Isidro Esther A Torres Alexandra González Myrella L Cruz Angel A Isidro Carmen I González-Keelan Priscilla Medero Caroline B Appleyard | 2016 | World Journal of Gastroenterology2016，22，13： | 5 |
| 2 | The impact of lung recruitment on hemodynamics during one-lung ventilation 显示文摘 | Garutti I Martinez G Cruz P | 2009 | Cardiothorac Vasc Anesth2009，23，4： | 1 |
| 3 | Purification of metallurgical grade silicon by acid leaching显示文摘 | SANTOS I C GONCALVES A P SANTOS C S ALMEIDA M AFONSO M H CRUZ M J | 1990 | Hydrometallurgy1990，23，： | 1 |
| 4 | Parametric study of the non-linear seismic response of three-dimensional building models显示文摘 | Fernandez-Davila V I Cruz E F | 2006 | Engineering Structures2006，28，5： | 1 |
| 5 | Popliteal artery entrapment syndrome in an elite rower: sonographie appearances 显示文摘 | Alvarez Rey I Alvarez Rey G Alvero Cruz JR | 2004 | J Ultrasound Med2004，23，12： | 1 |
| 6 | Highly Efficient Liquefaction of Woody Biomass in Hot-Compressed Alcohol-Water Co-solvents显示文摘 | Cheng S D'cruz I Wang M | 2010 | Energy & Fuels2010，24，9： | 1 |
| 7 | Gamma induced atom displacements in LYSO and LuYAP crystals as used in medical imaging applications显示文摘 | PIERA I CRUZ C M ABREU Y | 2015 | Nuclear Instruments and Methods in Physics Research Section B2015，，： | 1 |
| 8 | Simulation of hurricane-like disturbances on a Caribbean seagrass bed显示文摘 | CRUZ P V VAN T B I | 2005 | Journal of Experimental Marine Biology and Ecology2005，324，1： | 1 |
| 9 | Radiation processing of sewage and sludge: A review显示文摘 | Borrely S I Cruz A C Mastro N L D | 1998 | Progress in Nuclear Energy1998，33，12： | 1 |
| 10 | The inter- action of clay minerals with gypsum and its effects on copper - gold flotation显示文摘 | I Nestor Cruz Yongjun Peng Elaine Wightman Ning Xu | 2015 | Minerals Engineering2015，77，： | 1 |
| 11 | Sleep study abnor- malities in children with attention deficit hyperactivity dis- order显示文摘 | Goraya JS Cruz M Valencia I | 2009 | Pediatr Neurol2009，40，1： | 1 |
| 12 | MR imaging findings in Wernicke encephalopathy: nonalcoholics may be similar to alcoholics 显示文摘 | Hygino da Cruz LC Jr Domingues RC Vilanova I | 2010 | AJNR Am J Neuroradiol2010，31，6： | 1 |
| 13 | Treatment with fixed thyroxine doses in pregnant women with subclinical hypothyroidism显示文摘 | Seoane Cruz I Penin alvarez M Luna Cano R | 2012 | Endocfinol Nutr2012，59，5： | 1 |
| 14 | The role of ontologies in data in tegration显示文摘 | CRUZ I F XIAO H | 2005 | Engineering Intelligent Systems for Elec- trical Engineering and Communications2005，13，4： | 1 |
| 15 | RIFLE criteria for cardiac surgery-associated acute kidney injury: risk factors and outcomes显示文摘 | D'Onofrio A Cruz D Bolgan I | 2010 | Congest Heart Fail2010，161，： | 1 |
| 16 | Molecular simulation study of peptide amphiphile self-assembly显示文摘 | Velichko Y S Stupp S I dela Cruz M O | 2008 | J Phys Chem B2008，112，8： | 1 |
| 17 | Prognostic factors in head and neck adenoid cystic carci- noma显示文摘 | Da Cruz Perez DE de Abreu Aires F Nobuko Nishimoto I | 2006 | Oral Oncol2006，42，： | 1 |
| 18 | Two-stage first trimester screening for trisomy 21 by ultrasound assessment and biochemical testing显示文摘 | Kagan KO Staboulidou I Cruz J | 2010 | Ultrasound Obstet Gynecol2010，36，5： | 1 |
| 19 | Treatment of squamous cell carcinoma in situ:a review显示文摘 | Shimizu I Cruz A Chang KH | | 0，，10： | 1 |
| 20 | Urea- montmorillonite-extruded nanocomposites: A novel slow- release material 显示文摘 | PEREIRA E I MINUSS F B DA CRUZ C C T | 2012 | J Agric Food Chem2012，60，： | 1 |
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