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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter 显示文摘 | Procko E Ferrin- O' Connell I Ng SL | 2006 | Mol Cell2006，24，1： | 1 |
| 3 | Assessment in two shallow lakes of a hydroacoustic system for surveying aquatic macrophytes显示文摘 | WINFIELD I J ONOUFRIOU C CONNELL M J | 2007 | Shallow Lakes Assessment in two shallow lakes of a hydroacoustic system for surveying aquatic macrophytes2007，584，： | 1 |
| 4 | Intestinal intraepithelial lymphocytes bind to colon cancer cells by HML-1and CD11a显示文摘 | Roberts A I O’Connell S M and Ebert E C | 1993 | Cancer Res1993，53，7： | 1 |
| 5 | Cough lype aslhma:a review显示文摘 | O Connell E J Rojas A R Sachs M I | 1991 | Ann Allergy1991，66，28： | 1 |
| 6 | Measuring the cost of time in recreation demand analysis: an application to sport fishing显示文摘 | Mc Connell K E Strand I E | 1981 | American Journal of Agricultural Economics1981，63，1： | 1 |
| 7 | Interaction of PCB congeners and 2,3,7,8-TCDD in the rat liver:an electron microscope study显示文摘 | Connell BJ Singh A Chu I | 1998 | J-Submicrosc Cytol Pathol1998，30，1： | 1 |
| 8 | Assessment in two shallow lakes of a hydroacoustic system for surveying aquatic macro- phytes 显示文摘 | Winfield I J Onoufriou C O Connell M J | 2007 | H ydrobiologia2007，584，1： | 1 |
| 9 | Molecular mapping of capsaicinoid biosynthesis genes and quantitative trait loci analysis for capsaicinoid content in Capsicum显示文摘 | Blum E Mazourek M O'Connell M Curry J Thorup T Liu K Jahn M Paran I | | 0，，1： | 1 |
| 10 | Inspection and evaluation of lined above- ground storage tank bottoms in the petroleum industry显示文摘 | I O'Connell Michael | 1997 | Journal of Protective Coatings & Linings1997，14，3： | 1 |
| 11 | Prospective analysis of preoperative and intraoperative investigations for the diagnosis of in- fection at the sites of two hundred and two revision total hip arthro- plasties显示文摘 | Spangehl M I Masri BA O' Connell JX | 1999 | J Bone Joint Surg Am1999，81，5： | 1 |
| 12 | PCB congener 126-induced ultrastructural alterations in the rat liver: a stereological study 显示文摘 | Connell B J Singh A Chu I | 1999 | Toxicology1999，136，： | 1 |
| 13 | Radial oxygen loss from intact roots of Halophila ovalis as a function of distance behind the root tip and shoot illumination显示文摘 | Connell E L Colmer T D Walker D I | 1999 | Aquatic Botany1999，63，34： | 1 |
| 14 | Genome of hepatitis B virus:restriction enzyme cleavage and structure of DNA extracted from Dane particles显示文摘 | Summers J O' Connell A Millman I | 1975 | Proc Natl Acad Sci USA1975，72，： | 1 |
| 15 | Vital signs: increased medicaid prescriptions forpreexposure prophylaxis against HIV infection-New York, 2012-2015 显示文摘 | LAUFER F N O'CONNELL D A FELDMAN I | 2015 | MMWR Morb Mortal Wkly Rep2015，64，46： | 1 |
| 16 | On the group rings显示文摘 | CONNELL I G | 1963 | J Math1963，15，： | 1 |
| 17 | Guanosine protects againstreperfusion injury in rat brains after ischemic stroke显示文摘 | Connell BJ Di Iorio P Sayeed I、 | 2013 | J NeurosciRes2013，91，2： | 1 |
| 18 | Occurrence and distribution of PAHs in surface sediments and water from the Brisbane River Estuary,Australia 显示文摘 | KAYAL S I CONNELL D W | 1989 | Estuar Coast Shelf S1989，，29： | 1 |
| 19 | Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesisT显示文摘 | TOPISIROVIC I GUZMAN M L MC CONNELL M J | 2003 | Mol Cell Biol2003，23，24： | 1 |
| 20 | Guanosine protects against reperfusion injury in rat brains after ischemie stroke显示文摘 | Connell B J Di IP Sayeed I | 2013 | J Neuros- ci Res2013，91，2： | 1 |
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