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| 1 | Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis显示文摘 | Jing Yang Sendurai A Mani Joana Liu Donaher Sridhar Ramaswamy Raphael A Itzykson Christophe Come Pierre Savagner Inna Gitelman Andrea Richardson Robert A Weinberg | 2004 | Cell2004，，7： | 3 |
| 2 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 3 | Outrenal artery stenosis managed without revascularization 显示文摘 | Chabova V Schirger A comes of atherosclerotic Stanson AW | 2000 | Mayo Clin Proc2000，75，5： | 1 |
| 4 | Prognostic value of very early seizures for in-hospital mortality in atherothrombotic infarction 显示文摘 | Arboix A Comes E Garcia-Eroles L | 2003 | Eur Neurol2003，50，2： | 1 |
| 5 | cell-free formation of protease-resistant prion protein显示文摘 | Kocisko D A Come J H Priola S A | 1994 | Nature1994，370，： | 1 |
| 6 | Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis显示文摘 | Jing Yang Sendurai A Mani Joana Liu Donaher Sridhar Ramaswamy Raphael A Itzykson Christophe Come Pierre Savagner Inna Gitelman Andrea Richardson Robert A Weinberg | 2004 | Cell2004，，7： | 1 |
| 7 | Caspofungin treatment in severely ill,immunocompromised patients;a case-documentation study of 118 patients显示文摘 | Glasmacher A Comely OA Orlopp K | | 0，，： | 1 |
| 8 | the importance of pre-traumacentre treatment of life-threatening events on the patients transferredwith severe trauma显示文摘 | Comes E Araujo R Cameiro A | 2010 | Resuscitation2010，81，44： | 1 |
| 9 | 显示文摘 | CORT(E)S-J(A)COME M A ESCOBAR J ANGELES CH(A)VEZ C LPEZ-SALINAS E ROMERO E FERRAT G TOLEDO-ANTONIO J A | 2008 | Catal Today2008，130，1： | 1 |
| 10 | Acetazolamide and chronic hypoxia: effects on hemorheology and pulmonary hemodynamics 显示文摘 | Pichon A Comes P Quidu P | 2012 | Eur Respir J2012，，： | 1 |
| 11 | Preoperative chemotherapy in primary operable breast cancer results from the european organization for research and treatment of cancer trial显示文摘 | Jos A vanderHage Comelis JH | 2001 | J Clin Oncol2001，19，： | 1 |
| 12 | Distribution,movements and diet of macrocrustaceans on a Scottish sandy beach with particular reference to predation on juvenile fishes 显示文摘 | Ansell A D Comely C A Robb L | 1999 | Mar Ecol Prog Set1999，176，： | 1 |
| 13 | Trigonella foenum - graecum(fenugreek) seed extract as an antineoplastic agent 显示文摘 | Sur P Das M Comes A | 2001 | Phy - tother Res2001，15，3： | 1 |
| 14 | Vaginal colonization by Candida in asymptomatic women with and without a history of recurrent vulvovaginal candidiasis显示文摘 | Giraldo P von Nowaskonski A Comes FA | | 0，，： | 1 |
| 15 | Severe outbreaks of tomato yellow leaf curl Serdinia virus in Calabria, Southern Italy显示文摘 | Crescenzi A Comes S Napoli C | 2004 | Commun Agric Appl Bio Sci2004，69，4： | 1 |
| 16 | Polyomavirus persistence in lymphocytes: prevalence in lymphocytes from blood donors and healthy personel of a blood transrusion center显示文摘 | Dolei A Pietopaolo V Comes E | 2000 | J Gon Viral2000，，： | 1 |
| 17 | N- (2-Carboxyethyl) Chitosan: Regioselective Synthesis, Characterization and Protolytic Equilibria显示文摘 | Skorik Yury A Comes Carlos A R Vasconcelos M Teresa S D | 2003 | Carbohydr Res2003，338，3： | 1 |
| 18 | The sequencing of chemotherapy and radiation therapy after conservative surgery for patients with early-stage breast cancer显示文摘 | Come SE Gelman RS et a I | 1996 | N Eng 1 J]Med1996，334，9： | 1 |
| 19 | CIP2A is associated with hu-man breast cancer aggressivity 显示文摘 | Come C Laine A Chanrion M | 2009 | Clin Cancer Res2009，15，16： | 1 |
| 20 | A wavelet based lossless compression scheme with progressive transmission capability 显示文摘 | Munteanu A Comelis J Auwera G V D | 1999 | International Journal oflmaging Systems Technology(S1098-1098)1999，10，1： | 1 |
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