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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | 左心质量与脑磁共振成像和认知功能的关系显示文摘左心室质量(1eft ventricularmass,LVM)被证实可以作为长期暴露于数个危险因素下时造成的靶器官损害的评估标准。有关中年LVM和晚期认知表现之间联系的资料很少。纳入StrongHeart研究(SHS,1993—1995)及其附属的CDCAI(脑血管病及其对美国印第安人的影响)研究(2010—2013)中721名成年研究对象(平均基础年龄56岁),这些人群心血管病风险较高。 | 黄洁 叶鹏 Haring B Omidpanah A Suchy Dicey AM Best LG Verney SP Shibata DK Cole SA Ali T Howard BV Buchwald D Devereux RB | 2017 | 中华高血压杂志2017，25，10： | 4 |
| 3 | Trade, the pollution haven hypothesis and the environmental Kuznets curve: examining the linkages显示文摘 | Matthew A Cole | 2003 | Ecological Economics2003，，1： | 3 |
| 4 | Observations of the RT instability in laser imploded microballoons显示文摘 | Wark J S Kilkeany J D Cole A J | 1986 | Appl Phys Lett1986，48，15： | 2 |
| 5 | Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia 显示文摘 | Lucas A Morley R Cole TJ | 1988 | Br Meal J1988，297，6659： | 1 |
| 6 | Efficacy of zinc in the treatment of severe pneumonia in hospitalized children < 2 y old 显示文摘 | Bose A Coles CL Gunavathi | 2006 | Am J Clin Nutr2006，83，： | 1 |
| 7 | Human chorionic gonadotropin tests显示文摘 | Cole L A | 2009 | Expert reviews Mol Diagn2009，9，7： | 1 |
| 8 | Novel bronsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | Cole A C Jensen J L Ntai I | 2002 | Journal of the American Chemical Society2002，124，21： | 1 |
| 9 | Virus infection expands a biased subset of T ceils that bind tetrameric class I peptide complexes 显示文摘 | COLES R M JONES C M BROOKS A G | 2003 | Eur J Immunol2003，33，6： | 1 |
| 10 | Detect Runways in Complex Airport Scenes显示文摘 | Huertas A Cole W Nevatia R | 1990 | Computer Vision Graphics and Image Processing1990，24，2： | 1 |
| 11 | The dietary energy values of soya-bean oil, tallow and their blends for growing/finishing pigs显示文摘 | WISEMAN J COLE D J A HARDY B | 1990 | Animal Production1990，50，3： | 1 |
| 12 | The Forgotten Stakeholder? Ethics and Social Respon- sibility in Relation to Competitors 显示文摘 | Spence L J Coles A Harris L | 2001 | Business and Society Review2001，106，4： | 1 |
| 13 | Double intussusception fatally complicated by clostridial infection in a dog(a case report) 显示文摘 | Okewole P A Odeyemi P S Cole T | 1989 | Br Vet J1989，145，3： | 1 |
| 14 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 15 | Remediation of pesticide contaminated soil by planting and compost addition 显示文摘 | COLE M A ZHANG L LIU X | 1995 | Compost Sci Utiliza1995，3，4： | 1 |
| 16 | Inflammation and Alzheimer' s disease 显示文摘 | Akiyama H Barger S Barnum S Bradt B Bauer J Cole GM et a/ | 2000 | Neurobiol Ag- ing2000，21，3： | 1 |
| 17 | Nitrate, bacteria and human health 显示文摘 | Lundberg J O Weitzberg E Cole J A | 2004 | Nature Reviews Microbiology2004，2，7： | 1 |
| 18 | Radiographic follow-up of 84 operatively treated scapula neck and body fractures显示文摘 | Cole P A Gauger E M Herrera D A | | 0，，03： | 1 |
| 19 | Good for the soul:The rela- tionship between work, wellbeing and psychological capital显示文摘 | Cole K Daly A Mak A | 2009 | The Journal of Socio- Economies2009，38，： | 1 |
| 20 | 查看详情显示文摘 | Cole A C Jensen J L Ntai I Tran K L T Weaver K J Forbes D C Davis J H Jr | | 0，，： | 1 |
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