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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | Discrete event sequencing as a traveling salesman problem显示文摘 | Kosiba E D Wright J R Cobbs A E | 1992 | Computers in Industry1992，19，3： | 1 |
| 3 | Cardiopul monary resuscitation by chest Compression alone or with morth-to-morth ventilation显示文摘 | Hllstrom A Cobb L Johnson E | | 0，，： | 1 |
| 4 | Properties of unitary 1PSPs evoked by anatomically identified basket cells in the rat hippocampus 显示文摘 | Buhl E H Cobb S R Halasy K | 1995 | European Journal of Neuroscience1995，7，9： | 1 |
| 5 | Discrete event sequencing as a traveling salesman problem显示文摘 | KOSIBA E D WRIGHT J R COBBS A E | 1992 | Computers in Industry1992，19，3： | 1 |
| 6 | SETI@home: An Experiment in Public-resource Computing显示文摘 | Anderson D P Cobb J Korpela E | 2002 | Communications of the ACM2002，45，11： | 1 |
| 7 | Self- synchronization of transient rotations in multiple shaft systems显示文摘 | DIMENTBERG M COBB E MENSCHING J | 2001 | Journal of Vibration and Control2001，7，2： | 1 |
| 8 | Biliary atresia-an autoimmune disorder?显示文摘 | Vasiliauskas E Cobb L Vidrich A | 1995 | Journal of Pediatric Gastroenterology & Nutrition1995，21，3： | 1 |
| 9 | How MAP kinases are regulated显示文摘 | Cobb M H Goldsmith E J | | 0，，25： | 1 |
| 10 | Generalizing newcomererelational and organizational identi- fications:Processes and prototypicality显示文摘 | Sluss D M Ployhart R E and Cobb M G | 2012 | Academy of Management Journal2012，55，4： | 1 |
| 11 | Cardiopulmonary resuscitation by chest compression alone or with mouth to mouth ventilation 显示文摘 | Halstrom A Cobb L Johnson E | 2000 | N Eng J Med2000，342，11： | 1 |
| 12 | Expression of nitric oxide synthase in human central nervous system tumors显示文摘 | Charles S Cobbs Jay E | 1995 | Cancer Res1995，15，55： | 1 |
| 13 | SETI@home: an experiment in public-resource computing显示文摘 | Anderson P Cobb J Korpela E | 2002 | Communications of the ACM2002，45，11： | 1 |
| 14 | Cardiopulmonary resuscitation by chest compression alone or with mouth-to-mouth ventilation显示文摘 | Hallstrom A Cobb L Johnson E | 2000 | N Engl J Med2000，342，21： | 1 |
| 15 | Fuzzy set approaches to spatial data mining of association rules显示文摘 | Ladner R Petry F E Cobb M A | 2003 | Transactions in GIS2003，7，1： | 1 |
| 16 | Out-of-hospital cardiac arrest in men and women显示文摘 | Kim C Fahrenbruch C E Cobb L A | 2001 | Circulation2001，104，： | 1 |
| 17 | Influence of cardiopulmonary resuscitation prior to defibrillation in patients with out-of-hospital ventricular fibrillation显示文摘 | Cobb L A Fahrenbruch C E Walsh T R | 1999 | JAMA1999，281，13： | 1 |
| 18 | Mechanisms of cell injury and death显示文摘 | Cobb J P Hotchkiss R S Karl I E | 1996 | Br J Anaesth1996，77，1： | 1 |
| 19 | Uptake of perchlorate in terrestrial plants显示文摘 | Yu L Cafias J E Cobb G P | 2004 | Ecotoxicology and Environmental Sqfety2004，58，1： | 1 |
| 20 | Generalizing Newcomers' Relational and Organizational Identifications:Processes and Prototypicality 显示文摘 | Sluss D M Ployhart R E Cobb M G | 2012 | Academy of Management Journal2012，55，4： | 1 |
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