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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | Understanding the medial ulnar collateral ligament of the elbow: Review of native ligament anatomy and function显示文摘The medial ulnar collateral ligament complex of the elbow, which is comprised of the anterior bundle [AB, more formally referred to as the medial ulnar collateral ligament(MUCL)], posterior(PB), and transverse ligament, is commonly injured in overhead throwing athletes. Attenuation or rupture of the ligament results in valgus instability with variable clinical presentations. The AB or MUCL is the strongest component of the ligamentous complex and the primary restraint to valgus stress. It is also composed of two separate bands(anterior and posterior) that provide reciprocal function with the anterior band tight in extension, and the posterior band tight in flexion. In individuals who fail co-mprehensive non-operative treatment, surgical repair or reconstruction of the MUCL is commonly required to restore elbow function and stability. A comprehensive understanding of the anatomy and biomechanical properties of the MUCL is imperative to optimize reconstructive efforts, and to enhance clinical and radiographic outcomes. Our understanding of the native anatomy and biomechanics of the MUCL has evolved over time. The precise locations of the origin and insertion footprint centers guide surgeons in proper graft placement with relation to bony anatomic landmarks. In recent studies, the ulnar insertion of the MUCL is described as larger than previously thought, with the center of the footprint at varying distances relative to the ulnar ridge, joint line, or sublime tubercle. The purpose of this review is to consolidate and summarize the existing literature regarding the native anatomy, biomechanical, and clinical significance of the entire medial ulnar collateral ligament complex, including the MUCL(AB), PB, and transverse ligament. | Joshua R Labott William R Aibinder Joshua S Dines Christopher L Camp | 2018 | World Journal of Orthopedics2018，9，6： | 4 |
| 3 | Service recovery: a framework and empirical investigation显示文摘 | Janis L Miller Christopher W Craighead Kirk R Karwan | 2000 | Journal of Operations Management2000，，4： | 3 |
| 4 | HER-2/neu protein overexpression and gene amplification in human transitional cell carcinoma of the bladder显示文摘 | Christopher L Coogan Carlos R Estrada Shiv Kapur Kenneth J Bloom | 2004 | Urology2004，，4： | 2 |
| 5 | Effect of Ginkgo biloba (EGb 761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular disease: a randomized clinical trial显示文摘 | Christopher D Gardner James L Zehnder Alison J Rigby Joel R Nicholus John W Farquhar | 2007 | Blood Coagulation & Fibrinolysis2007，，8： | 2 |
| 6 | Why the Western Pacific Subtropical High Has Extended Westward since the Late 1970s显示文摘 | Zhou Tianjun Yu Rucong Zhang Jie Drange Helge Cassou Christophe Deser Clara Hodson Daniel L R Sanchez-Gomez Emilia Li Jian Keenlyside Noel Xin Xiaoge Okumura Yuko | 2009 | Journal of Climate2009，，8： | 2 |
| 7 | Production of dimethylfuran for liquid fuels from biomass-derived carbohydrates显示文摘 | Yuriy R L Christopher J B Zhen Y L | 2007 | Nature2007，447，： | 1 |
| 8 | A cost-effectiveness analysis of intraoperative cholangiography in the prevention of bile duct injury during laparoscopic cholecystectomy显示文摘 | David R Flum Christopher Flowers David L Veenstra | 2003 | Journal of the American College of Surgeons2003，，3： | 1 |
| 9 | Vasopressin: a new target for the treatment of heart failure显示文摘 | Craig R Lee Michael L Watkins J.Herbert Patterson Wendy Gattis Christopher M O'Connor Mihai Gheorghiade Kirkwood F Adams | 2003 | American Heart Journal2003，，1： | 1 |
| 10 | Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile Rhesus monkeys显示文摘 | Christopher L Coe Marian Kramer Boldizsár Czéh Elizabeth Gould Alison J Reeves Clemens Kirschbaum Eberhard Fuchs | 2003 | Biological Psychiatry2003，，10： | 1 |
| 11 | Impact of microscopic hepalic lymph node involvement on survival after resection of colorectal liver metastasis显示文摘 | CHRISTOPHE L ANTONIO S ERIC R | 2004 | J Am Coll Surg2004，198，6： | 1 |
| 12 | From Business Reengineering to Management Reengineering 显示文摘 | Edwin R Christoph T Sascha L S | 1995 | Management International Review1995，，4： | 1 |
| 13 | Identification and mapping of polymorphic SSR markers from expressed gene sequences of barley and wheat显示文摘 | HOLTON T A CHRISTOPHER J T MCCLURE L HARKER N HENRY R J | 2002 | Molecular Breeding2002，9，： | 1 |
| 14 | Vitrificationg enhancement by synthetic ice blocking agents 显示文摘 | Brain W Eugen L Christopher M R | 2000 | Cryobiology2000，，： | 1 |
| 15 | Service recovery:a framework and empirical investigation显示文摘 | Janis L Miller Christopher W Craighead Kirk R Karwan | 2000 | Journal of Operations Management2000，，18： | 1 |
| 16 | Characterisation by EIS of ternary Mg alloys synthesized by mechanical alloying显示文摘 | CHRISTOPHER M A BRETT DIAS L TR1NDADE B FISCHER R M1ES S | 2006 | Electrochimica Acta2006，51，： | 1 |
| 17 | Comparison of electrom agnetic absorber used in anechoic and semianechoic chambers for emission and immunity testing of digital devices显示文摘 | HOLLOWAY Christopher L DELYSER Ronald R GGE-RMAN Robert F | 1997 | EMC IEEE Trans on1997，39，1： | 1 |
| 18 | Synthesis,characterization,and catalytic properties of amicroporous/mesoporous material,MMM-1显示文摘 | RAJA H P POLADI R CHRISTOPHER C L | 2002 | J SolidState Chem2002，167，： | 1 |
| 19 | Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators显示文摘 | Ana-Maria Bamberger Karin Milde-Langosch Elena R?ssing Christoph Goemann Thomas L?ning | 2001 | Journal of Cancer Research and Clinical Oncology2001，，9： | 1 |
| 20 | Comparison of Electromagnetic Absorber Used in Anechoic and Semi-Anechoic Chambers for Emissions and Immunity Testing of Digital Devices 显示文摘 | CHRISTOPHER L RONALD R ROBERT F | 1997 | IEEE Transactions On Electronic magnetic Compatibility1997，39，： | 1 |
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