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| 1 | High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells显示文摘AIM: To analyze the relevance of the microRNA miR-196a for colorectal oncogenesis. METHODS: The impact of miR-196a on the restriction targets HoxA7, HoxB8, HoxC8 and HoxD8 was analyzed by reverse transcription polymerase chain reaction (RT-PCR) after transient transfection of SW480 cancer cells. The miR-196a transcription profile in colorectal cancer samples, mucosa samples and diverse cancer cell lines was quantifi ed by RT-PCR. Transiently miR-196a-transfected colorectal cancer cells were used for diverse functional assays in vitro and for a xenograft lung metastasis model in vivo. RESULTS: HoxA7, HoxB8, HoxC8 and HoxD8 were restricted by miR-196a in a dose-dependent and gene-specific manner. High levels of miR-196a activated the AKT signaling pathway as indicated by increased phosphorylation of AKT. In addition, high levels of miR-196a promoted cancer cell detachment,migration, invasion and chemosensitivity towards platin derivatives but did not impact on proliferation or apoptosis. Furthermore, miR-196a increased the development of lung metastases in mice after tail vein injection. CONCLUSION: miR-196a exerts a pro-oncogenic influence in colorectal cancer. | Carl Christoph Schimanski Kirsten Frerichs Fareed Rahman Martin Berger Hauke Lang Peter R Galle Markus Moehler Ines Gockel | 2009 | World Journal of Gastroenterology2009，15，17： | 40 |
| 2 | In-situ cosmogenic ^(36)Cl denudation rates of carbonates in Guizhou karst area显示文摘This study quantifies surface denudation of carbonate rocks by the first application of in-situ cosmogenic36Cl in China. Concentrations of natural Cl and in-situ cosmogenic36Cl in bare carbonates from Guizhou karst areas were measured with isotope dilution by accelerator mass spectrometer. The Cl concentration varied from 16 to 206 ppm. The 36Cl concentrations were in range of (0.8-2.4)106 atom g-1 , resulting in total denudation rates of 20-50 mm ka-1 that averaged over a 104-105 a timescale. The 36Cl-denudation rates showed roughly a negative correlation with the local mean temperature. This preliminary observation may suggest the variations of proportions of chemical weathering and physical erosion in denudation process, depending upon local climatic conditions. | XU Sheng LIU CongQiang FREEMAN Stewart LANG YunChao SCHNABEL Christoph TU ChengLong WILCKEN Klaus ZHAO ZhiQi | 2013 | Chinese Science Bulletin2013，58，20： | 7 |
| 3 | Extracts from cotton over the whole growing season induce Orobanche cumana(sunflower broomrape) germination with significant cultivar interactions显示文摘Five cotton cultivars and their parents were tested for induction of germination of Orobanche cumana Wallr.(sunflower broomrape) seeds in pot and field experiments. Germination rates induced by cotton root extracts were the highest followed by stem extracts then leaf extracts. Cotton seedlings at the six-leaf stage induced higher germination than seedling at the two-and four-leaf stage, in all five cotton cultivars and their parents. In the field, the highest concentration of cotton root extracts gave the highest germination rate of O. cumana, and the lowest concentration of cotton root extracts gave the lowest germination rate. Methanol extracts of cotton rhizosphere soil gave the highest germination of O. cumana. In general,the root, stem and leaf extracts were more active at the sixleaf stage than other seedling stages. In conclusion,extracts of cotton rhizosphere soil and tissues have high activity in the seedling stage. Extracts of cotton across the whole growing season were able to induce O. cumana germination but displayed significant cultivar interactions. | Ming LANG Rui YU Yongqing MA Wei ZHANG Christopher S.P.McErlean | 2017 | Frontiers of Agricultural Science and Engineering2017，4，2： | 3 |
| 4 | Are IFRS-based and US GAAP-based accounting amounts comparable?显示文摘 | Mary E. Barth Wayne R. Landsman Mark Lang Christopher Williams | 2012 | Journal of Accounting and Economics2012，，1： | 3 |
| 5 | Right Living Donor Liver Transplantation: An Option for Adult Patients: Single Institution Experience With 74 Patients显示文摘 | Massimo Malagó Giuliano Testa Andrea Frilling Silvio Nadalin Camino Valentin-Gamazo Andreas Paul Hauke Lang Ulrich Treichel Vito Cicinnati Guido Gerken Christoph Erich Broelsch | 2003 | Annals of Surgery2003，，6： | 2 |
| 6 | Pulmonary Vein Denervation Enhances Long-Term Benefit After Circumferential Ablation for Paroxysmal Atrial Fibrillation显示文摘 | Carlo Pappone Vincenzo Santinelli Francesco Manguso Gabriele Vicedomini Filippo Gugliotta Giuseppe Augello Patrizio Mazzone Valter Tortoriello Giovanni Landoni Alberto Zangrillo Christopher Lang Takeshi Tomita Cézar Mesas Elio Mastella Ottavio Alfieri | 2004 | Circulation: Journal of the American Heart Association2004，，3： | 2 |
| 7 | Economic implication of alternative allocation schemes for emission allowances 显示文摘 | Christoph Boehringer and Andreas Lange | 2005 | The Scandinavian Journal of Economics2005，107，3： | 1 |
| 8 | Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning 显示文摘 | Gremer H Lange R Christoph A | 1994 | Nature1994，367，6462： | 1 |
| 9 | Neural correlates of anxiety associated with obsessive-compulsive symptom dimensions in normal volunteers显示文摘 | David Mataix-Cols Sarah Cullen Kezia Lange Fernando Zelaya Christopher Andrew Edson Amaro Michael J Brammer Steven C.R Williams Anne Speckens Mary L Phillips | 2003 | Biological Psychiatry2003，，6： | 1 |
| 10 | On the Design of Optimal Grandfathering Schemes for Emission Allowances显示文摘 | CHRISTOPH BOHRINGER ANDREAS LANGE | 2005 | Eur Econ Rev2005，49，8： | 1 |
| 11 | Simultaneous quantitative analysis of ternary mixtures of d -mannitol polymorphs by FT-Raman spectroscopy and multivariate calibration models显示文摘 | Doris E. Braun Stephan G. Maas Neslihan Zencirci Christoph Langes Nora A. Urbanetz Ulrich J. Griesser | 2009 | International Journal of Pharmaceutics2009，，1： | 1 |
| 12 | Inactivation of the NCAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning显示文摘 | CREMER H LANGE R CHRISTOPH A | 1994 | Nature1994，367，： | 1 |
| 13 | Survival and Recurrence Rates after Resection for Hepatocellular Carcinoma in Noncirrhotic Livers显示文摘 | Hauke Lang Georgios C. Sotiropoulos Eirini I. Brokalaki Klaus Jürgen Schmitz Christian Bertona Gabriele Meyer Andrea Frilling Andreas Paul Massimo Malagó Christoph E. Broelsch | 2007 | Journal of the American College of Surgeons2007，，1： | 1 |
| 14 | Expansion and characteristics of human T regulatory type 1 cells in co-cultures simulating tumor microenvironment显示文摘 | Christoph Bergmann Laura Strauss Reinhard Zeidler Stephan Lang Theresa L. Whiteside | 2007 | Cancer Immunology Immunotherapy2007，，9： | 1 |
| 15 | Surgical Management of Segmental and Sectoral Bile Duct Injury After Laparoscopic Cholecystectomy: a Challenging Situation显示文摘 | Jun Li Andrea Frilling Silvio Nadalin Sonia Radunz Juergen Treckmann Hauke Lang Massimo Malago Christoph Erich Broelsch | 2010 | Journal of Gastrointestinal Surgery2010，，2： | 1 |
| 16 | Effect of cirrhosis and liver transplantation on the gender difference in QT interval显示文摘 | Adegboyega Q. Adigun Amar G. Pinto David A. Flockhart J. Christopher Gorski Lang Li Stephen D. Hall Naga Chalasani | 2005 | The American Journal of Cardiology2005，，5： | 1 |
| 17 | Stem cell engineering for treatment of heart diseases: Potentials and challenges显示文摘 | Shengwen Calvin Li Lang Wang Hong Jiang Julyana Acevedo Anthony Christopher Chang William Gunter Loudon | 2008 | Cell Biology International2008，，3： | 1 |
| 18 | [123I]Iodometomidate for Molecular Imaging of Adrenocortical Cytochrome P450 Family 11B Enzymes显示文摘 | Stefanie Hahner Andrea Stuermer Michael Kreissl Christoph Reiners Martin Fassnacht Heribert Haenscheid Felix Beuschlein Martina Zink Katharina Lang Bruno Allolio Andreas Schirbel | 2008 | The Journal of Clinical Endocrinology & Metabolism2008，，： | 1 |
| 19 | CT fluoroscopy guided percutaneous gastrostomy or jejunostomy without (CT-PG/PJ) or with simultaneous endoscopy (CT-PEG/PEJ) in otherwise untreatable patients显示文摘 | Fritz W. Spelsberg Ralf-Thorsten Hoffmann Reinhold A. Lang Hauke Winter Rolf Weidenhagen Maximilian Reiser Karl-Walter Jauch Christoph Trumm | 2013 | Surgical Endoscopy2013，，4： | 1 |
| 20 | Mapping quantitative trait loci using generalized estimating equations显示文摘 | Christoph Lange John C Whittaker | 2001 | Genetics2001，159，： | 1 |
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