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| 1 | Multivariate statistical analysis of clinicopathologic factors influencing survival of patients with bile duct carcinoma显示文摘AIM: To evaluate the influence of various clinicopathologicfactors on survival of patients with bile duct carcinoma aftercurative resection.METHODS: A retrospective analysis was made for 86 casesof bile duct carcinoma treated from January 1981 toSeptember 1995. Fifteen clinicopathologic factors possiblyinfluencing survival were selected. Independent variableswere first analyzed by univariate methods. Survival forvariable was estimated by the method of Kaplan and Meier.The variables that were statistically significant by univarlateanalysis were included in a multivariate analysis, which wereconfirmed using the Cox stepwise proportion hazard modelwith the help of SPSS 10.0 for Windows software.RESULTS: The overall cumulative survival rate was 72.6 %at 1 year, 32.4 % at 3 years, and 18.7 % at 5 years. Theresults of univariate analysis showed that the majorsignificant prognostic factors influencing survival of thesepatients were histological type of lesion, lymph nodemetastasis, pancreatic invasion, duodenal invasion, pedneuralinvasion, macroscopic vessel involvement, resected surgicalmargin and depth of cancer invasion (P=0.02, 0.02, 0.004,0.005, 0.01, 0.43, 0.03 and 0.04). Age, sex, location of tumor,size of tumor, macroscopic type of lesions, hepaticmetastasis, and hepatic invasion were not significantlyassociated with prognosis (P>0.05). Pancreatic invasion,perineural invasion and lymph node metastases were thethree most important prognostic factors by multivariateanalysis using the Cox proportional hazards model.CONCLUSION: Pancreatic invasion, pedneural invasion andlymph node metastases are the most important prognosticfactors for bile duct carcinoma after curative resection. | He, P Shi, JS Chen, WK Wang, ZR Ren, H Li, H | 2002 | World Journal of Gastroenterology2002，8，5： | 10 |
| 2 | Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis显示文摘Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune responses.However,the immunopathological effects and underlying intracellular regulatory mechanisms of uric acid crystal-mediated activation of fibroblast-like synoviocytes(FLS)in rheumatoid arthritis(RA)have not been elucidated.Therefore,we investigated the in vitro effects of monosodium urate crystals,alone or in combination with the inflammatory cytokines tumor-necrosis factor(TNF)-a or interleukin(IL)-1b,on the activation of human FLS from RA patients and normal control subjects and the underlying intracellular signaling mechanisms of treatment with these crystals.Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6,the chemokine CXCL8 and the matrix metalloproteinase(MMP)-1 from both normal and RA-FLS(all P,0.05).Moreover,the additive or synergistic effect on the release of IL-6,CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-a or IL-1b.Further experiments showed that the release of the measured inflammatory cytokine,chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase pathway.Our results therefore provide a new insight into the uric acid crystal-activated immunopathological mechanisms mediated by distinct intracellular signal transduction pathways leading to joint inflammation in RA. | Da P Chen Chun K Wong Lai S Tam Edmund K Li Christopher WK Lam | 2011 | Cellular & Molecular Immunology2011，8，6： | 5 |
| 3 | Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor - induced HepG2 cell invasion involving both MAPK/ERKs and PI3K -Akt pathways 显示文摘 | Lee WJ Wu LF Chen WK | 2006 | Chem Biol Interact2006，160，2： | 1 |
| 4 | Inhibition of vascular endothelial cell morphogeneais in cultures by limbal epithelial cells 显示文摘 | Ma DHK Tsai RJF Chu WK Kao CH Chen JK | 1999 | Invest Ophthalmol Vis Sci1999，40，： | 1 |
| 5 | Biomechanical analysis of unilateral fixation with interbody cages显示文摘 | Chen HH Cheung HH Wang WK | 2005 | Spine2005，1530，4： | 1 |
| 6 | Effect of Silver Nano-Fluid on Pulsating Heat Pipe Thermal Performance 显示文摘 | Yu HL Shung WK Chen HL | 2008 | Applied Thermal Engineering2008，28，13： | 1 |
| 7 | Specific immunotherapy suppresses Th2 responses via modulating TIM1/ TIM4 interaction on dendritic cells显示文摘 | Zhao CQ Li TL He SH Chen X An YF Wu WK | 2010 | Allergy2010，65，8： | 1 |
| 8 | Biomechanical analysis of Unilateral fixation with interbody cages显示文摘 | Chen HH Cheung HH Wang WK | 2005 | Spine2005，30，4： | 1 |
| 9 | Atypical embryo phenotypes identified by time-lapse microscopy:high preva- lence and association with embryo 显示文摘 | Athayde WK Chen AA Conaghan J | 2014 | Fertil Steril2014，101，6： | 1 |
| 10 | Outcomes of emer- gency treatmentin rupturet hepatocellular carcinoma in the ED显示文摘 | CHEN WK CHANG YT CHUNG YT | 2005 | Am J Emerg Med2005，23，： | 1 |
| 11 | Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells显示文摘 | Lee WJ Chen WK Wang C J | 2007 | Toxicol Appl Pharmacol2007，226，： | 1 |
| 12 | White matter hyperintensities in post-stroke depression:a case control study显示文摘 | Tang WK Chen YK Lu JY | 2010 | J Neurol Neurosurg Psychiatry2010，81，12： | 1 |
| 13 | Cerebral microbleeds and depression in lacunar stroke 显示文摘 | Tang WK Chen YK Lu JY | 2011 | Stroke2011，42，9： | 1 |
| 14 | Hydrogen peroxide increases the activity of rat sympathetic preganglionic neurons in vivo and in vitro显示文摘 | Lin HH Chen CH Hsieh WK | 2003 | Neuroacience2003，121，3： | 1 |
| 15 | Outcomes of emer- gency treatment in ruptured hepatocellular carcinoma in the ED显示文摘 | Chen WK Chang YT Chung YT | 2005 | Am J Ererg Med2005，23，： | 1 |
| 16 | Biomechanicalanalysis of unilateral fixation with interbody cages显示文摘 | Chen HH Cheung HH Wang WK | 2005 | Spine(Phila Pa 1976)2005，30，4： | 1 |
| 17 | Lateral mass anchoring screws for cervical laminoplasty:preliminary report of a novel technique 显示文摘 | Chen HC Chang MC Yu WK | 2008 | J Spinal Disord Tech2008，21，6： | 1 |
| 18 | In vitro assessment of Macleaya cordata crude extract bioactivity and anticancer properties in normal and cancerous human lung cells显示文摘 | Liu M Lin YL Chen XR Liao CC Poo WK | 2013 | Exp Toxicol Pathol2013，65，6： | 1 |
| 19 | Combined spinal epidural for labor analgesia-duration,efficacy and side effects of adding sufentanil or fentanyl to bupivacaine intrathecally vs plain bupivacaine显示文摘 | Lo WK Chong JL Chen LH | 1999 | Singapore Med J1999，40，10： | 1 |
| 20 | Epidemiology and clinical presentation of the four human parainfluenza virus types显示文摘 | Liu WK Liu Q Chen DH | 2013 | BMC Infect Dis2013，13，： | 1 |
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