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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction显示文摘 | Xiao-E Jia Ke Ma Tao Xu Lei Gao Shuang Wu Cong Fu Wenjuan Zhang Zhizhang Wang Kaiyu Liu Mei Dong Changbin Jing Chunguang Ren Zhiwei Dong Yi Chen Yi Jin Qiuhua Huang Xing Chang Min Deng Li Li Lingfei Luo Jun Zhu Yongjun Dang Hung-Chun Chang Leonard I Zon Yi Zhou Saijuan Chen Weijun Pan | 2015 | Cell Research2015，25，8： | 8 |
| 3 | STELLADELIN D,A NEW CYCLIC UNDECAPEPTIDE FROM STELLARIA DELAVAYI显示文摘STELLADELIND,ANEWCYCLICUNDECAPEPTIDEFROMSTELLARIADELAVAYI￥YuRuiZHAO;JunZHOU;XianKaiWANG;XiaoLinHUANG;HouMingWU;ChangXiangCHEN... | Yu Rui ZHAO Jun ZHOU Xian Kai WANG Xiao Lin HUANG Hou Ming WU Chang Xiang CHENG (Depepartment of Medicinal Chemistry of Natural Products,School ofPharmacy, West China University of Medical Sciences,Chengdu, 610041)(Laboratory of Phytochemistry,Kunming I | 1996 | Chinese Chemical Letters1996，7，3： | 4 |
| 4 | Chemical shift phase-difference and suppression magnetic resonance imaging techniques in animals, phantoms, and humans显示文摘 | Mitchell DG Kim I Chang TS | 1991 | Investigative Radiology1991，26，12： | 2 |
| 5 | 早产儿出生时气管内吸出物中的白介素-6含量增加是随后支气管肺发育不良的预测因子显示文摘Aim:We tested whether interleukin-6(IL-6)in tracheal aspirate(TA)at birth,as a marker of fetal pulmonary inflammation,can be a predictor of bronchopulmonary dysplasia(BPD)in preterm infants.Methods:A total of 75 preterm(≤32 wk)infants who were intubated in the delivery room were prospectively enrolled.Multivariate logistic regression analysis was done to determine whether IL-6 in TA at birth is an independent risk factor for BPD,and a receiver-operating characteristic curve was constructed to determine the accuracy of IL-6 in TA for predicting the risk of BPD.Results:IL-6 in TA at birth was an independent risk factor for BPD.Fetal pulmonary inflammation defined as IL-6 in TA at birth ≥316 pg/ml together with patent ductus arteriosus(PDA)additively predicted the risk of BPD.The sensitivity,specificity,and positive and negative predictive values of fetal pulmonary inflammation for the identification of BPD were 73%,71%,58%and 83%,respectively.Conclusion:IL-6 in TA at birth can be used as a predictor of BPD in combination with the presence of PDA. | Chang W. C Kim B. I Kim H. - S 郭战宏(译) | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，2，8： | 2 |
| 6 | Chemical vapor deposition of Si nanowires nucleated by TiSi2 islands on Si显示文摘 | Kamins T I Stanley Williams R Chang Y L | 2000 | Appl Phys Lett2000，76，5： | 2 |
| 7 | Bifurcation analysis of a non-linear hysteretic oscillator under harmonic excitation显示文摘 | Chang S I | 2004 | J Sound Vib2004，276，12： | 1 |
| 8 | Small interfering RNA-induced suppression of ERCC1 enhances sensitivity of human cancer cells to cisplatin显示文摘 | CHANG I Y KIM M H KIM H B | 2005 | Bioehem Biophys Res Commun2005，327，1： | 1 |
| 9 | Generalized constrained energy minimization approach to subpixel target detection for multispectral imagery 显示文摘 | C -I Chang H Ren | 2000 | Optical Engineering2000，39，5： | 1 |
| 10 | Automatic spectral target recognition in hyperspectral imagery显示文摘 | REN H CHANG C I | 2003 | IEEE Transactions on Aerospace and Electronic Systems2003，39，4： | 1 |
| 11 | Query reformulation using automatically generated query concepts from a document space显示文摘 | Chang Y Ounis I Kim M | 2006 | Information Processing and Management2006，42，： | 1 |
| 12 | Behavior of double skin composite wall subjected to in- plane cyclic loading显示文摘 | Eom T S Park H G Lee C H Kim J H Chang I H | 2009 | Journal of Structural Engineering ASCE2009，135，10： | 1 |
| 13 | The involvement of tyrosine kinases,cyclic AMP/protein kinase A,and p38 mitogen-activated protein kinase in IL-13-mediated arginase I induction in macrophages:its implications in IL-13-inhibited nitric oxide production显示文摘 | Chang C I Zoghi B Liao J C | 2000 | J Immunol2000，165，： | 1 |
| 14 | Biodegradation of phenanthrene and pyrene fi-om mangrove sediment in subtropical Taiwan显示文摘 | CHANG B V CHANG I T YUAN S Y | 2008 | J environ sci health2008，43，3： | 1 |
| 15 | Static friction coefficient model for metallic rough surfaces 显示文摘 | Chang W R Etsion I Bogy D B | 1988 | ASME Journal of Tribology1988，110，1： | 1 |
| 16 | Adhesion model for metallic rough surfaces显示文摘 | Chang W R Etsion I Bogy D B | 1988 | Journal of Tribology1988，110，1： | 1 |
| 17 | Effects of membrane foul- ing on solute rejection during membrane filtration of acti- vated sludge 显示文摘 | Chang I S Bag S O Lee C H | 2001 | Process Biochem2001，36，89： | 1 |
| 18 | Sludge chemical composition changes under uni-directional freezing 显示文摘 | Huang W T Chang I L Lee D J | 1996 | Water Science and Technology1996，34，34： | 1 |
| 19 | Molecular cloning of mesothelin,a differentiation antigen present on mesothelim,mesotheliomas,and ovarian cancers显示文摘 | Chang K Pastan I | 1996 | Proc Natl Acad Sci USA1996，93，： | 1 |
| 20 | Outcome after treatment for papillary thyroid cancer显示文摘 | I Lin JD Hsieh SH Chang HY | 2001 | Head Neck2001，23，2： | 1 |
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