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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | A new finite element model for welding heat sources 显示文摘 | Goldak J Chakravarti A Bibby M | 1984 | Metal Trans1984，15，： | 2 |
| 3 | A new finite model for welding heat source 显示文摘 | Goldak J Chakravarti A Bibby M | 1984 | Metallurgual Transactions1984，15，2： | 1 |
| 4 | Prognos- tic and pathologic significance of quantitative protein expression profiling in human gliomas显示文摘 | Chakravarti A Delaney M A Noll E | 2001 | Clin Cancer Res2001，7，： | 1 |
| 5 | Evolutionary traceresidues in Noroviruses : importance in receptor binding, antigenicity, virion assembly, and strain diversity 显示文摘 | Chakravarty S Hutson A M Estes M K | 2005 | J Virol2005，79，1： | 1 |
| 6 | Toll-like receptor 4 on nonhema-topoietic cells sustains CNS inflammation during endotoxemia, in-dependent of systemic cytokines显示文摘 | Chakravarty S Herkenham M | 2005 | J Neurosci2005，25，7： | 1 |
| 7 | A new finite element model for welding heat sources 显示文摘 | Goldak J Chakravarti A Bibby M | 1984 | Metallurgical & Materials Transac- tions B1984，15，2： | 1 |
| 8 | Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus:results of a multicenter,phase Ib,double-blind,placebo-controlled,dose-escalating trial显示文摘 | Dall'Era M Chakravarty E Wallace D | 2007 | Arthritis Rheum2007，56，： | 1 |
| 9 | A new finite element model for welding heat sources显示文摘 | Goldak J Chakravarti A Bibby M | 1984 | Metallurgical Transactions B1984，15，2： | 1 |
| 10 | A New Finite Element Model for Welding Heat Sources 显示文摘 | Goldak J Chakravarti A Bibby M | 1984 | Metallurgical Transactions1984，15，2： | 1 |
| 11 | Perforator flap:A novel method for providing skin cover to lower limb defects显示文摘 | Mukherjee MK Alam Parwaz M Chakravarty B | 2012 | Med J Armed Forces India2012，68，4： | 1 |
| 12 | High rate of preterm birth in pregnancies complicated by rheumatoid arthritis 显示文摘 | Langen ES Chakravarty EF Liaquat M | 2014 | AmJPerinatol2014，31，1： | 1 |
| 13 | A new finite el- ement model for welding heat sources显示文摘 | GOLDAK A CHAKRAVARTI A BIBBY M | 1984 | Metallurgical Transaction B1984，15，2： | 1 |
| 14 | A new finite model for welding heat source显示文摘 | Goldak J Chakravarti A Bibby M | 1984 | Metallurgual Transactions1984，15，2： | 1 |
| 15 | Evolutionary trace residues in Noroviruses:importance in receptor binding,antigenicity,virion assembly,and strain diversity显示文摘 | Chakravarty S Hutson A M Estes M K | 2005 | J Virol2005，79，1： | 1 |
| 16 | Effect of Density, Microstructure, and Strain Rate on Com- pression Behavior of Polymeric Foams 显示文摘 | SAHA M C MAHFUZ H CHAKRAVARTY U K | 2005 | Materials Sci- ence and Engineering A2005，406，12： | 1 |
| 17 | J Med Chem显示文摘 | Chakravarty P K Carlp L Weber M J | 1983 | 26:6331983，26，： | 1 |
| 18 | A New Finite Element Model for Welding Heat Resource显示文摘 | Goldak J Chakravarti A Bibby M | 1984 | Metallurgical Transaction B1984，15，2： | 1 |
| 19 | SmallmoleculeMAPK inhibitors restore radioiodine incorporation inmouse thyroid cancers with conditional BRAF activation显示文摘 | CHAKRAVARTY D SANTOS E RYDER M | 2011 | J Clin Invest2011，121，12： | 1 |
| 20 | The organic grid: self-organizing computation on a peer-to-peer network 显示文摘 | CHAKRAVARTI A J BAUMGARTNER G LAURIA M | 2005 | IEEE Trans on Systems Man and Cybernetics2005，35，3： | 1 |
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