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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Antiproliferative effect and apoptotic response in vitro of human melanoma cells to liposomes containing the ribosome-inactivating protein luffin显示文摘 | Poma A Marcozzi G Cesare P | 1999 | Biochim Biophys Acta1999，1472，12： | 1 |
| 3 | Degradation of sodium an thraquin-one sulphonate by free and immobilized bacterial cultures显示文摘 | Meriem B Nevenka A Cesar P | 1994 | Appl Microbiol Biotechnol1994，41，1： | 1 |
| 4 | Ion channels gated by heat 显示文摘 | Cesare P Moriondo A Vellani V | 1999 | Proceedings of the National Academy of Sciences of the United States of America1999，96，14： | 1 |
| 5 | Chloroplast isolation from Laminaria digitata:A reproducible methodology yielding photosynthetically active chloroplasts显示文摘 | STRBAC D MARCOAURELIO A R CESAR P | 1994 | Planta1994，195，： | 1 |
| 6 | Antiproliferative effect and apoptotic response in vitro of human melanoma cells to liposomes containing the ribosome-inactivating protein luffin显示文摘 | Poma A Marcozzi G Cesare P | 1999 | Biochim Biophys Acta1999，1472，12： | 1 |
| 7 | Ion channels gated by heat 显示文摘 | Cesare P Moriondo A Vellani V | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 8 | Proportional-integral observer for systems modeled by nond gGraphs 显示文摘 | CESAR P A AHMED R GENEVIEVE D T | 2005 | Simulation modeling practice and theory2005，13，： | 1 |
| 9 | The IL-23/Th17 axis in the immunopathogenesis of psoriasis 显示文摘 | Di Cesare A Di Meglio P Nestle FO | 2009 | J Invest Derma- to12009，129，6： | 1 |
| 10 | Degradation of sodium anthraquinone sulphonate by free and immobilized bacterial cultures显示文摘 | MERIEM B NEVENKA A CESAR P | 1994 | Appl MicrobiolBiotechnol1994，41，1： | 1 |
| 11 | Design of an integrated low power high CMRR instrumentation amplifier for biomedical applications 显示文摘 | CESAR A P | 2008 | Analog Integrate Circuit Signal Process2008，57，4： | 1 |
| 12 | The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans显示文摘 | Di Meglio P Di Cesare A Laggner U | 2011 | Plo S one2011，6，17： | 1 |
| 13 | Upward shift of the lower range of coronary flow autoregulation in hypertensive patients with hypertrophy of the left ventricle显示文摘 | Polese A de Cesare N Montorsi P | 1991 | Circulation1991，83，3： | 1 |
| 14 | Acute retroviral syndrome and high baseline viral load are predictors of rapid HIV progression among un- treated Argentinean seroconverters 显示文摘 | Soclas ME Sued O Laufer N Lfzaro ME Mingrone H Pryluka D Remondegui C Figueroa MI Cesar C Gun A Turk G Bouzas MB Kavasery R Krolewiecki A P6rez H Salom6u H Cahn P Grupo Argentino de Seroconversi6r Study Group | 2011 | J Int AIDS Soc2011，14，1： | 1 |
| 15 | Prevention and control of cystic echinococcosis显示文摘 | Philip S Craig Donald P McManus Marshall W Lightowlers Jose A Chabalgoity Hector H Garcia Cesar M Gavidia Robert H Gilman Armando E Gonzalez Myriam Lorca Cesar Naquira Alberto Nieto Peter M Schantz | 2007 | The Lancet Infectious Diseases2007，，6： | 1 |
| 16 | The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans显示文摘 | Di Meglio P Di Cesare A Laggner U | 2011 | PLoS One2011，6，17： | 1 |
| 17 | The IL-23/Th17 Axisin the Immunopathogenesis of Psoriasis显示文摘 | Cesare A D Meglio P D Nestle F O | 2009 | J Invest Dermatol2009，129，6： | 1 |
| 18 | The JOpera Visual Composition Language 显示文摘 | Cesare P Gustavo A | 2005 | Journal of Visual Languages and Computing2005，，2： | 1 |
| 19 | True blue:Blue-emitting aluminum(III) quinolinolate complexes显示文摘 | Cesar P B Montes V A Pavel A | | 0，，24： | 1 |
| 20 | The IL-23/Th17 axis in the immunopathogenesis of psoriasis显示文摘 | Di Cesare A Di Meqlio P Nestle FQ | 2009 | J Invest Dermatol2009，129，6： | 1 |
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