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| 1 | Mini-Cog测试结果与老年骨折患者并发症及谵妄高风险有关显示文摘既位对于围手术期危险因素的分析,通常采用美国麻醉医师协会(American Society of Anesthesiologists,ASA)评分等全身状态分类方法。Mini-Cog测试是一种快速、易行、有效且观察者间变异较小的认知评估工具,可测量急性应激状态下患者在执行功能障碍和回忆方面的认知储备。 | Heng M Eagen CE Javedan H 胡玮 杨进城 | 2016 | 中国骨科临床与基础研究杂志2016，8，4： | 3 |
| 2 | Genotype phenotype correlation in Wilson's disease within families-a report on four south Indian families显示文摘AIM: To study the genotype phenotype correlation in Wilson's disease (WD) patients within families. METHODS: We report four unrelated families from South India with nine members affected with WD. Phenotype was classified as per international consensus phenotypic classifi cation of WD. DNA was extracted from peripheral blood and 21 exons of ATP7B gene and flanking introns were amplified by polymerase chain reaction (PCR). The PCR products were screened for mutations and the aberrant products noted on screening were sequenced. RESULTS: Four separate ATP7B mutations were found in the four families. ATP7B mutations were identical amongst affected members within each family. Three families had homozygous mutations of ATP7B gene while one family had compound heterozygous mutation, of which only one mutation was identifi ed. We noted concordance between ATP7B gene mutation and Wilson's disease phenotype amongst members within each family. The age of onset of symptoms or of detection of asymptomatic disease, baseline serum ceruloplasmin and baseline urinary copper levels were also similar in affected members of each family. Minor differences in phenotype and baseline serum ceruloplasmin level were noted in one family.CONCLUSION: We report concordance between ATP7B mutation and WD phenotype within each family with > 1 member affected with WD. Homozygous ATP7B mutation was present in 3 of the 4 families studied. Our report supports allelic dominance as a determinant of WD phenotype. However, in one family with compound heterozygous mutation, there was a similar WD phenotype which suggests that there may be other factors determining the phenotype. | S Santhosh RV Shaji CE Eapen V Jayanthi S Malathi P Finny N Thomas M Chandy G Kurian GM Chandy | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 3 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 4 | 稳定性冠状动脉疾病患者的尿11-脱氢血栓素B_2与死亡率的关系显示文摘已有研究证明,应用阿司匹林抗血小板治疗可减少冠状动脉疾病(coronary artery disease,CAD)患者的不良预后。阿司匹林不可逆地抑制血小板环加氧酶1(cyclooxygenase-1,COX-1)并减弱血栓烷A2(thromboxane A2,TXA2)介导的血小板聚集, | 刘莉 叶鹏 McCullough PA Vasudevan A Sathyamoorthy M Schussler JM Velasco CE Lopez LR Swift C Peterson M Bennett-Firmin J Schiffmann R Bottiglieri T | 2017 | 中华高血压杂志2017，25，1： | 3 |
| 5 | Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica显示文摘Objective:To evaluate the anti-oxidani and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica in in vitro conditions.Methods:In vitro DPPH radical scavenging activity and lipoxygenase(LOX) inhibition assays were used to evaluate the anti-oxidant and anti-inflammatory activities respectively.Methanolic extract(MEMI),successive water extract (SWMI) and ethyl acetate fraction(EMEMI),n-butanol fraction(BMEMI) and water soluble fraction (WMEMI) of methanolic extract were evaluated along with respective reference standards. Results:In in ritro DPPH radical scavenging activity,the MEMI,EMEMI and BMEMI have offered significant antioxidant activity with IC50 values of 13.37.3.55 and 14.19μig/mL respectively.Gallic acid,a reference standard showed significant antioxidant activity with IC? value of 1.88 and found to be more potent compared to all the extracts and fractions.In m vitro LOX inhibition assay,the MEMI,EMEMI and BMEMI have showed significant inhibition of LOX enzyme activity with IC50 values of 96.71.63.21 and 107.44μg/mL respectively.While,reference drug Indometlhacin also offered significant inhibtion against LOX enzyme activity with IC50 of 57.75.Furthermore,MEMI was found to more potent than SWMI and among the fractions EMEMI was found to possess more potent antioxidant and anti-inflammatory activity.Conclusions:These findings suggest that the MEMI and F.MEMT possess potent anti-oxidani and anti-inflammatory activities in in vitro conditions. | Mohan CG Deepak M Viswanatha GL Savinay G Hanumantharaju V Rajendra CE Praveen D Halemani | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，4： | 2 |
| 6 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 7 | Bcl-x,a bcl-2 reled gene that functions as a dominant regulator of apoptotic cell deth 显示文摘 | Boise LH Gonzalea-Carcia M Postema CE | 1993 | Cell1993，74，4： | 1 |
| 8 | Matrix metalloproteinases:a Tail of a frog that became a prince显示文摘 | BRINCKERHOFF CE M ATRISIAN LM | 2002 | Nat Rev Mol Cell Biof2002，3，： | 1 |
| 9 | Cutaneous head anti neck squamous celt carcinoma metastatic to parotid and cervical lymph nodes 显示文摘 | Veness M J Porceddu S Pahne CE | 2007 | Head Neck2007，29，7： | 1 |
| 10 | Treatment of postherpetic neuralgia: a review of therapeuie options 显示文摘 | Argoff CE Katz N Backonja M | 2004 | J Pain Symptom Marage2004，28，4： | 1 |
| 11 | Meconium aspiration produces airway hyperresponsiveness and eosinophilic inflammation in a mufine model显示文摘 | Khan AM Elidemir O Epstein CE Lally KP Xue H Blackbum M | 2002 | Am J Physiol Lung Cell Moll Physiol2002，283，4： | 1 |
| 12 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 13 | HLA-DP as specific target for cellular immunotherapy in HLA class Ⅱ-ex- pressing B-cell leukemia 显示文摘 | Rutten CE van Luxemburg-Heijs SA Griffioen M | 2008 | Leukemia2008，22，7： | 1 |
| 14 | Consequences of epilepsy in the developing brain:implications for surgical management显示文摘 | Stafstrom CE Lynch M Sutula TP | 2000 | Semin Pediatr Neurol2000，7，3： | 1 |
| 15 | One mineral density and fracture risk in type-2 diabetes mellitus:The Rotterdam study 显示文摘 | de Liefde II van der Klift M de Laet CE | 2005 | Osteoporosis Int2005，16，： | 1 |
| 16 | Intravenous microdialysis sampling in awake, freely-moving rats显示文摘 | Telting-Diaz M Scott Do Lunte CE | 1992 | Anal Chem1992，64，7： | 1 |
| 17 | Sebocytes are the key regulators of androgen homeostasis in human skin 显示文摘 | Fritsch M Orfanos CE Zouboulis CC | 2001 | J Invest Dermatol2001，116，5： | 1 |
| 18 | 显示文摘 | Juiffre M Meer GM Hack CE | 2001 | Am J Trop Med Hyg2001，65，1： | 1 |
| 19 | Liver damage in the rat induces hepatocyte stem cells from biliary epithelial cells显示文摘 | Alison MR Golding M Sarraf CE | 1996 | Gastroenterology1996，110，： | 1 |
| 20 | Immunohistochemical localization of transforming growth factor-beta in human implantation sites 显示文摘 | Selick CE Horowitz GM Gratch M | 1994 | J Clin Endocrinol Metab1994，78，3： | 1 |
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