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| 1 | Herbicide resistant fertile transgenic wheat plant obtained by microprojectile bombardment of regenerable embryogenic callus显示文摘 | Vasil V Castillo A M Fromm M E Vasil I K | 1992 | Bio/Tech1992，10，： | 2 |
| 2 | Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences显示文摘Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal ofintrons and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that allows the alternative usage of exons, the retention ofintronic sequences and the generation of exonic sequences of variable length. Most human genes undergo splicing events, and disruptions of this process have been associated with a variety of diseases, including cancer. Hepatocellular carcinoma (HCC) is a molecularly heterogeneous type of tumor that usually develops in a cirrhotic liver. Alterations in pre-mRNA splicing of some genes have been observed in liver cancer, and although still scarce, the available data suggest that splicing defects may have a role in hepatocarcinogenesis. Here we briefly review the general mechanisms that regulatepre-mRNA splicing, and discuss some examples that illustrate how this process is impaired in liver tumorigenesis, and may contribute to HCC development. We believe that a more thorough examination of pre-mRNA splicing is still needed to accurately draw the molecular portrait of liver cancer. This will surely contribute to a better understanding of the disease and to the development of new effective therapies. | Carmen Berasain Saioa Gońi Josefa Castillo Maria Ujue Latasa Jesús Prieto Matias A Avila | 2010 | World Journal of Gastroenterology2010，16，25： | 2 |
| 3 | In-plant evaluation of a lactic acid treatment for reduction of bacteria on chilled beef carcasses显示文摘 | CASTILLO A LUCIA L M MERCADO I | 2001 | Food Protection2001，，64： | 1 |
| 4 | Upper u rinary tract transitional cell carcinoma: current treatment op tions and minimally invasive approaches显示文摘 | Vidal Mora I Castillo O Velasco Palma A | 2009 | Arch Esp Urol2009，62，5： | 1 |
| 5 | Predictors of the level of patient satisfaction in a university hospital显示文摘 | Castillo L Dougnac A Vicente I | | 0，，06： | 1 |
| 6 | Insulin resistance in critical illness 显示文摘 | Dhar A Castillo I | 2011 | curr Opin Pediatr2011，23，3： | 1 |
| 7 | Depressed mood in breast cancer survi- vors : Associations with physical activity, cancer - related fatigue, quality of life, and fitness level显示文摘 | GALIANO CASTILLO N ARIZA GARCIA A CANTARERO VILLANUEVA I | 2014 | Eur J Oncol Nurs2014，18，2： | 1 |
| 8 | Molecular signature of brain injury after intracerebral hemorrhage显示文摘 | Castillo J Davalos A Alvarez-Sabin I | 2002 | Neurology2002，58，： | 1 |
| 9 | A study of the Candida albicans cell wall proteome 显示文摘 | Castillo L Calvo E Mart nez A I | 2008 | Proteomics2008，8，18： | 1 |
| 10 | Herbicide resistant fertile transgenic wheat plants obtained by microprojectilebombardment of regenerable embryogenic callus显示文摘 | Vasil V Castillo A M Fromm M E Vasil I K | 1992 | Nature Biotechnology1992，10，： | 1 |
| 11 | Recombinant interferon-γ as adjuvant to hepatitis B vaccine in hemodialysis patients 显示文摘 | QUIROGA J A CASTILLO I PORRES J C | 1990 | Hepatology1990，12，4： | 1 |
| 12 | I- solation and characterization of a putative liver progenitor popula- tion after treatment of fetal pat hepatocytes with TGF-beta显示文摘 | Del Castillo G Alvarez-Barrientos A Carmona-Cuenca I | 2008 | J Cell Physiol2008，215，3： | 1 |
| 13 | Laparoscopic Partial nephrectomy: an experience in 227 cases 显示文摘 | CASTILLO O A LOPEZ-FONTANA G VIDAL-MORA I | 2014 | Actas Urol Esp2014，38，2： | 1 |
| 14 | A polymer electrode with variable conductivity:polypyrrole显示文摘 | DAIZ A F CASTILLO J I | 1980 | J Chem Soc Commun1980，14，： | 1 |
| 15 | A distinct lineage of influenza A virus from bats显示文摘 | Tong S Li Y Rivailler P Conrardy C Castillo D A Chen L M Recuenco S Ellison J A Davis C T York I A Turmelle A S Moran D Rogers S Shi M Tao Y Weil M R Tang K Rowe L A Sammons S Xu X Frace M Lindblade K A Cox N J Anderson L J Rupprecht C E Donis R O | 2012 | PANS2012，109，11： | 1 |
| 16 | Hyperlipidemic chicken as a model of non-alcoholic steatohepatitis显示文摘 | Ayala I Castillo A M Adanez G | 2009 | Exp Biol Med2009，234，： | 1 |
| 17 | Herbicide resistant fertile transgenic wheat plants obtained by microprojectile bombardment of regenerable embryogenic callus显示文摘 | Vasil V Castillo A M Fromn M E Vasil I K | 1992 | Bio/Tech1992，10，： | 1 |
| 18 | Prevalence and evolutionary origins of the del(GJB6>D13S1830) mutation in the DFNB1 locus in hearing-impaired subjects:a multicenter study显示文摘 | DEL CASTILLO I MORENO-PELAYO M A DEL CASTILLO F J | 2003 | Am J Hum Genet2003，73，： | 1 |
| 19 | Synthesis of polyelec- trolyte complexes of polyaniline and sulfonated polystyrene by palm tree peroxidase显示文摘 | Sakharov I Y Vorobiev A C Castillo J J | 2003 | Enzyme and Microbial Technology2003，33，5： | 1 |
| 20 | IL-8 signaling plays a critical role in the Epithelial-Mesen-chymal transition of human carcinoma cells显示文摘 | FERNANDO R I CASTILLO M D LITZINGER M A | 2011 | Cancer Res2011，71，15： | 1 |
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