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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Analysis of peridural scar formation and its prevention after lumbar laminotomy and discectomy in dogs显示文摘 | SONGER M N RAUSCHNING W CARSON E W | 1995 | Spine1995，20，5： | 1 |
| 3 | A modular spinal rod linkage system to provide rotational stability显示文摘 | Asher M Carson W Heinig C | 1988 | Spine1988，13，3： | 1 |
| 4 | 显示文摘 | Jolly M R Bender J W Carson J | 1998 | SPIE1998，3327，： | 1 |
| 5 | The Importance of Storage, Transfer and Collection 显示文摘 | KNOWLTON T M CARSON J W KLINZING G E | 1994 | Chemical Engineering Progress1994，90，1： | 1 |
| 6 | Atrial fibrillation in pregnancy associated with oral terbutaline显示文摘 | Carson M P Fisher A J Scorza W E | 2002 | Obstet Gynecol2002，100，5： | 1 |
| 7 | Effect of supplementation with barium selenate on the fertility, prolificacy and lambing performance of hill sheep 显示文摘 | Mufioz C Carson A F McCoy M A Dawson L E Irwin D Gordon A W Kilpatriek D J | 2009 | The Veterniary Record2009，164，9： | 1 |
| 8 | Model validation for the August 10,1996 WSCC system outage显示文摘 | Dmitry N K Carson W T William A M | 1999 | IEEE Transactions on Power Systems1999，14，3： | 1 |
| 9 | Genome sequence of Streptococcus mutans UA159,a cariogenic dental pathogen 显示文摘 | Ajdic D McShan W M McLaughlin R E Savie G Chang J Carson M B | 2002 | Proc Natl Aead Sci USA2002，99，14： | 1 |
| 10 | Contingent valuation 显示文摘 | CARSON R T HANEMANN W M | 2005 | Hand- book of Environmental Economics2005，，2： | 1 |
| 11 | Fenofibrate represses interleukin-17 and interferon-γ expression and improves colitis in interleukin-10-deficient mice 显示文摘 | Lee J W Bajwa P J Carson M J | 2007 | Gastroenterology2007，133，1： | 1 |
| 12 | A modular rod link- age system to provide rotational stability 显示文摘 | Asher M Carson W Heinig C | 1988 | Spine1988，13，3： | 1 |
| 13 | Interleuldn IL - 15 is a novel cytokine that activates human natural killer cells via compo- nents of the IL - 2 receptor显示文摘 | Carson W E Lindemann 1~1 J Linett M L | 1994 | J Exp Ned1994，180，： | 1 |
| 14 | Model validation for August 10, 1996 WSCC system outage显示文摘 | Dmitry N K Carson W T William A M | 1999 | IEEE Trans on Power Systems1999，14，3： | 1 |
| 15 | Simultaneous determination of multiple tetracycline residues in milk by metal chelate affinify chromatography 显示文摘 | Carson M C Breslyn W | 1996 | Journal of AOAC Internation at1996，79，1： | 1 |
| 16 | Coating electrospun collagen and gelatin fibers with perlecan domain Ⅰ for increased growth factor binding 显示文摘 | Casper L C Yang W Farach Carson M C | 2007 | Biomacromolecules2007，8，4： | 1 |
| 17 | The critical role of Notch ligand delta-like 1 in the pathogenesis of influenza A virus ( H1 N1 ) infection 显示文摘 | ITO T ALLEN M CARSON W F IV | 2011 | Plos Pathogen2011，7，10： | 1 |
| 18 | Theory of selection for yield of plants in disease stress environments显示文摘 | Carson M L Wicks Z W | 1989 | Phytopathology1989，79，： | 1 |
| 19 | Clinical and genetic aspects of primary ciliary dyskinesia/Kartagener syndrome显示文摘 | Leigh M W Pittman J E Carson J L | 2009 | Genet Med2009，11，7： | 1 |
| 20 | Plant density determines species richness along an experimental fertility gradient显示文摘 | Stevens M H Carson W P | 1999 | Ecology1999，80，2： | 1 |
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