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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Drought stress and tropical for-est woody seedlings:Effect on community structure and composi-tion显示文摘 | BUNKER D E CARSON W P | 2005 | Journal of Ecology2005，93，4： | 1 |
| 3 | Efficacy of powered intracapsular tonsillectomy and adenoidectomy 显示文摘 | Tunkel D E Hotchkiss K S Carson K A | 2008 | Laryngoscope2008，118，7： | 1 |
| 4 | Effect of supplementation with barium selenate on the fertility, prolificacy and lambing performance of hill sheep 显示文摘 | Mufioz C Carson A F McCoy M A Dawson L E Irwin D Gordon A W Kilpatriek D J | 2009 | The Veterniary Record2009，164，9： | 1 |
| 5 | Genome sequence of Streptococcus mutans UA159,a cariogenic dental pathogen 显示文摘 | Ajdic D McShan W M McLaughlin R E Savie G Chang J Carson M B | 2002 | Proc Natl Aead Sci USA2002，99，14： | 1 |
| 6 | Changes in Gene Expression During the Early to Mid-Luteal (Receptive phase) Transition in Human Endometrium Detected by High-Density Microarray Screening显示文摘 | Lagow E Thathiah A | 2002 | Mol Human Reprod2002，8，： | 1 |
| 7 | Valence-Band Electronic Structure of Silicon Nitride Studied with the Use of Soft-X-Ray Emission显示文摘 | Carson R D Schnatterly S E | 1986 | PhysicalReview B1986，33，： | 1 |
| 8 | Insights into transcriptional regulation by Foxp3显示文摘 | CARSON B D LOPES J E SOPER D M | 2006 | Front Biosci2006，11，： | 1 |
| 9 | Clinical deci-sion support, systems methodology, and telemedicine:their role in the management of chronic disease显示文摘 | Carson E R Cramp D G Morgan A | 1998 | IEEETrans Inf Technol Biomed1998，2，2： | 1 |
| 10 | Prostate cancer and neuroendocrine differentiation:more neu- ronal, less endocrine ? 显示文摘 | GRIGORE A D BEN- JACOB E FARACH- CARSON M C | 2015 | Front Oncol2015，5，： | 1 |
| 11 | Dealing with bio and ecological complexity: challenges and opportunities 显示文摘 | Carson E Feng D D Pons M N | 2006 | Annual Reviews in Control2006，30，1： | 1 |
| 12 | Is the world ocean warming?Upper-ocean temperature trends: 1950-2000显示文摘 | Harrison D E Carson M | 2007 | Journalof Physical Oceanography2007，37，2： | 1 |
| 13 | Ectopic pregnancy显示文摘 | Piserska M D Carson S A Buster J E | 1998 | Lancet1998，351，12： | 1 |
| 14 | Intradermal gene immunization:the possible role DNA uptake in the induction of cellular immunity to viruse显示文摘 | Raz Carson D A Parker S E | 1994 | Proc Natl Acad Sci USA1994，91，： | 1 |
| 15 | Changes in gene expression during the early to mid-luteal (receptive) transition in human endometrlum detected by high-density microarray screening显示文摘 | CARSON D D LAGOW E THATHIAH A et ol | 2002 | Mol Hum Repred2002，8，： | 1 |
| 16 | Biological communities at vent sites along subduction zone off Oregon显示文摘 | Suess E Carson B Ritger S D | 1985 | BiologicalSociety Bulletin(Washington)1985，6，： | 1 |
| 17 | Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening显示文摘 | Carson D D Lagow E Thathiah A | 2002 | Mol Human Reprod2002，8，3： | 1 |
| 18 | A new rapid technique for the characterization of lignin in vascular plants: thermochemolysis with tetramethylammonium hydroxide (TMAH) 显示文摘 | CLIFFORD D J CARSON D M MCKINNEY D E | 1995 | Organic Geochemistry1995，23，2： | 1 |
| 19 | Synergistic stimulation of Muc - 1 expression in normal breast epithelia and breast cancer cells by interferon - gamma and tumor necrosis factor - al - pa 显示文摘 | LAGOW E L CARSON D D | 2002 | J Cell Biochem2002，86，4： | 1 |
| 20 | Hydrologicalperformance of extensive green roofs in New York City:Observations and multi-year modeling of three full-scalesystems 显示文摘 | Carson T B Marasco D E Culligan P J | 2013 | Environmental Research Letters2013，8，2： | 1 |
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