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| 1 | Novel concepts in radiation-induced cardiovascular disease显示文摘Radiation-induced cardiovascular disease(RICVD) is the most common nonmalignant cause of morbidity and mortality among cancer survivors who have undergone mediastinal radiation therapy(RT).Cardiovascular complications include effusive or constrictive pericarditis,cardiomyopathy,valvular heart disease,and coronary/vascular disease.These are pathophysiologically distinct disease entities whose prevalence varies depending on the timing and extent of radiation exposure to the heart and great vessels.Although refinements in RT dosimetry and shielding will inevitably limit future cases of RICVD,the increasing number of long-term cancer survivors,including those treated with older higher-dose RT regimens,will ensure a steady flow of afflicted patients for the foreseeable future.Thus,there is a pressing need for enhanced understanding of the disease mechanisms,and improved detection methods and treatment strategies.Newly characterized mechanisms responsible for the establishment of chronic fibrosis,such as oxidative stress,inflammation and epigenetic modifications,are discussed and linked to potential treatments currently under study.Novel imaging modalities may serve as powerful screening tools in RICVD,and recent research and expert opinion advocating their use is introduced.Data arguing for the aggressive use of percutaneous interventions,such as transcutaneous valve replacement and drug-eluting stents,are examined and considered in the context of prior therapeutic approaches.RICVD and its treatment options are the subject of a rich and dynamic body of research,and patients who are at risk or suffering from this disease will benefit from the care of physicians with specialty expertise in the emerging field of cardiooncology. | Jason R Cuomo Gyanendra K Sharma Preston D Conger Neal L Weintraub | 2016 | World Journal of Cardiology2016，8，9： | 17 |
| 2 | Eosinophilic esophagitis: From pathophysiology to treatment显示文摘Eosinophilic esophagitis(Eo E) is a chronic immune disease, characterized by a dense eosinophilic infiltrate in the esophagus, leading to bolus impaction and refluxlike symptoms. Traditionally considered a pediatric disease, the number of adult patients with Eo E is continuously increasing, with a relatively higher incidence in western countries. Dysphagia and food impaction represent the main symptoms complained by patients, but gastroesophageal reflux-like symptoms may also be present. Esophageal biopsies are mandatory for the diagnosis of Eo E, though clinical manifestations and proton pump inhibitors responsiveness must be taken into consideration. The higher prevalence of Eo E in patients suffering from atopic diseases suggests a common background with allergy, however both the etiology and pathophysiology are not completely understood. Elimination diets are considered the firstline therapy in children, but this approach appears less effective in adults patients, who often require steroids; despite medical treatments, Eo E is complicated in some cases by esophageal stricture and stenosis, that require additional endoscopic treatments. This review summarizes the evidence on Eo E pathophysiology and illustrates the safety and efficacy of the most recent medical and endoscopic treatments. | Alessandra D’Alessandro Dario Esposito Marcella Pesce Rosario Cuomo Giovanni Domenico De Palma Giovanni Sarnelli | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 4 |
| 3 | 对上面的胃肠的道的活动性混乱的基因贡献显示文摘 Motility disorders of the upper gastrointestinal tract encompass a wide range of different diseases. Esophageal achalasia and functional dyspepsia are representative disorders of impaired motility of the esophagus and stomach, respectively. In spite of their variable prevalence, what both diseases have in common is poor knowledge of their etiology and pathophysiology. There is some evidence showing that there is a genetic predisposition towards these diseases, especially for achalasia. Many authors have investigated the possible genes involved, stressing the autoimmune or the neurological hypothesis, but there is very little data available. Similarly, studies supporting a post-infective etiology, based on an altered immune response in susceptible individuals, need to be validated. Further association studies can help to explain this complex picture and find new therapeutic targets. The aim of this review is to summarize current knowledge of genetics in motility disorders of the upper gastrointestinal tract, addressing how genetics contributes to the development of achalasia and functional dyspepsia respectively. | Giovanni Sarnelli Alessandra D’Alessandro Marcella Pesce Ilaria Palumbo Rosario Cuomo | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，4： | 3 |
| 4 | Diagnostic value of the ration of recovery sysolic blood pressure to peak exercise systolic blood pressure for the detection of coronary artery disease显示文摘 | Acanfora D DeCaprio LC Cuomo S | 1988 | Circulation1988，77，6： | 1 |
| 5 | Effect of dynamic myocardial dyssynchrony on mitral regurgitation during supine bicycle exercise stress echoeardiography in patients with idiopathic dilated cardiomyopathy and 'narrow' QRS显示文摘 | D'Andrea A Caso P Cuomo S | 2007 | Eur Heart J2007，28，8： | 1 |
| 6 | Total knee arthroplasty using a piecrusting technique for valgus deformity显示文摘 | Lup D Cuomo P | 2007 | Clin Orthop Relat Res2007，464，： | 1 |
| 7 | Total knee arthroplasty using a pie-crusting technique for valgus deformity显示文摘 | Aglietti P Lup D Cuomo P | | 0，，： | 1 |
| 8 | Effect of dynamic myocardial dyssynchrony on mitral regurgitation during supine bicycle exercise stress echocardiography in patients with idiopathic dilated cardiomyopathy and'narrow'QRS显示文摘 | D'Andrea A Caso P Cuomo S | 2007 | Eur Heart J2007，28，8： | 1 |
| 9 | Terrestrial vegetation cover activity as a problem of fluctuating surfaces显示文摘 | COPPOLA R CUOMO V D'EMILIO M | 2009 | Int J Mod Phys B2009，23，28： | 1 |
| 10 | Gastrointestinal regulation of food intake:do gut motility,enteric nerves and entero-hormones play together?显示文摘 | CUOMO R D'ALESSANDRO A ANDREOZZI P | 2011 | Minerva Endocrinol2011，36，： | 1 |
| 11 | Total knee arthroplasty using a pie-crusting technique for valgus deformity显示文摘 | Aglietti P Lup D Cuomo P | 2007 | Clin Orthop Relat Res2007，464，： | 1 |
| 12 | Effect of dynamic myocardial dyssynchrony on mitral regurgitation during supine bicycle exercise stress echocardiography in patients with idiopathic dilated cardiomyopathy and 'narrow' QRS显示文摘 | D'Andrea A Caso P Cuomo S | 2007 | Eur Heart J2007，28，8： | 1 |
| 13 | The astroglial derived S100beta protein stimulates the expression of nitric oxide synthase in rodent macrophages through p38 MAP kinase activation 显示文摘 | Esposito G De Filippis D Cirillo C Sarnelli G Cuomo R Iu vone T | 2006 | Life Sci2006，78，： | 1 |
| 14 | Severe polymyositis due to Toxoplasma gondii in an adult immunocompetent patient: a case report and review of the literature显示文摘 | G. Cuomo V. D’Abrosca V. Rizzo S. Nardiello G. Montagna G. B. Gaeta G. Valentini | 2013 | Infection2013，，4： | 1 |
| 15 | Effect of dynamic myocardial dyssynehro- ny ola mitral regurgitation during supine bicycle exercise stress echocardiography in patients with idiopathic dilated cardiomyopathy and ' narrow' QRS 显示文摘 | D' Andrea A Caso P Cuomo S | 2007 | Eur Heart J2007，28，： | 1 |
| 16 | Analysis of ambulatory duodenogastroesophageal reflux monitoring显示文摘 | Cuomo R Koek G Sifrim D | 2000 | Dig Dis Sci2000，45，： | 1 |
| 17 | Diagnostic value of the ratio of recovery systolic blood pressure to peak exercise systolic blood pressure for the detection of coronary disease 显示文摘 | Acanfora D Caprio LD Cuomo S | 1988 | Circulation1988，77，： | 1 |
| 18 | Total knee arthroplasty using a pie-crusting technique for valgus deformity显示文摘 | AGLIETTI P LUP D CUOMO P | 2007 | Clinical Orthopaedics and Related Research2007，464，： | 1 |
| 19 | Diagnostic value of the ratio of recovery systolic blood pressure to peak exercise systolic blood pressure for the detection of coronary artery disease 显示文摘 | Caprio LD Cuomo S | 1988 | Circulation1988，77，： | 1 |
| 20 | Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson ' s disease treatment 显示文摘 | Cuomo D Martella G Barabino E | 2009 | J Neurochem2009，109，4： | 1 |
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